Chemical Synthesis, Folding, and Structural Insights intoO-Fucosylated Epidermal Growth Factor-like Repeat 12 of Mouse Notch-1 Receptor

2010 ◽  
Vol 132 (42) ◽  
pp. 14857-14865 ◽  
Author(s):  
Kazumi Hiruma-Shimizu ◽  
Kensaku Hosoguchi ◽  
Yan Liu ◽  
Naoki Fujitani ◽  
Takashi Ohta ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Chemical Synthesis ◽  
Notch 1 ◽  
Epidermal Growth ◽  
Structural Insights

Chemical Synthesis, Structural Modeling, and Biological Activity of the Epidermal Growth Factor-like Domain of HumanCripto

Biochemistry ◽  
1997 ◽  
Vol 36 (13) ◽  
pp. 3837-3845 ◽  
Author(s):  
Matthias Lohmeyer ◽  
Paul M. Harrison ◽  
Subha Kannan ◽  
Marta DeSantis ◽  
Nicola J. O'Reilly ◽  
...  
Keyword(s):  
Biological Activity ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Chemical Synthesis ◽  
Structural Modeling ◽  
Epidermal Growth

Fmoc-based solid phase chemical synthesis of 71-meric neuregulin 1-β1, an epidermal growth factor-like domain

2008 ◽  
Vol 14 (3) ◽  
pp. 261-266
Author(s):  
Taeko Kakizawa ◽  
Shizuyo Koide-Yoshida ◽  
Tooru Kimura ◽  
Hiromasa Uchimura ◽  
Yoshio Hayashi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Chemical Synthesis ◽  
Solid Phase ◽  
Neuregulin 1 ◽  
Epidermal Growth ◽  
Phase Chemical

scholarly journals Notch-1 regulates transcription of the epidermal growth factor receptor through p53

2008 ◽  
Vol 29 (5) ◽  
pp. 918-925 ◽  
Author(s):  
Benjamin W. Purow ◽  
Tilak K. Sundaresan ◽  
Michael J. Burdick ◽  
Benjamin A. Kefas ◽  
Laurey D. Comeau ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Notch 1 ◽  
Epidermal Growth

scholarly journals Immunohistochemical expression of p63, epidermal growth factor receptor (EGFR) and notch-1 in radicular cysts, dentigerous cysts and keratocystic odontogenic tumors

2012 ◽  
Vol 23 (4) ◽  
pp. 337-343 ◽  
Author(s):  
Cláudia Kallás Gonçalves ◽  
Eduardo Rodrigues Fregnani ◽  
Jorge Esquiche Leon ◽  
Yara Teresinha Corrêa Silva-Sousa ◽  
Danyel Elias da Cruz Perez
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Epithelial Lining ◽  
Immunohistochemical Expression ◽  
Notch 1 ◽  
Dentigerous Cysts ◽  
Epidermal Growth ◽  
Keratocystic Odontogenic Tumors

The aim of this study was to assess the immunohistochemical expression of p63 protein, epidermal growth factor receptor (EGFR) and Notch-1 in the epithelial lining of radicular cysts (RC), dentigerous cysts (DC) and keratocystic odontogenic tumors (KOT). For this study, 35 RC, 22 DC and 17 KOT were used. The clinical and epidemiological data were collected from the patient charts filed in the Oral Pathology Laboratory, University of Ribeirão Preto, Brazil. Immunohistochemical reactions against the p63, EGFR and Notch-1 were performed in 3-µm-thick histological sections. The slides were evaluated according to the following criteria: negative: <5% of positive cells, low expression: 5-50% of positive cells, and high expression: >50% of positive cells. Moreover, the intensity of EGFR and Notch-1 expressions was also evaluated. Fisher's exact test and Spearman's correlation coefficients were used for statistical analysis, considering a significance level of 5%. Almost all cases demonstrated p63, EGFR and Notch-1 expressions. The p63 expression was significantly higher in KOT (p<0.001). Positive correlation between these immunomarkers was observed. These findings suggest the participation of p63, EGFR and Notch-1 in the development, maintenance and integrity of cystic odontogenic epithelial lining, favoring lesion persistence. The high expression of p63 in KOT suggests that it may be related to their more aggressive biological behavior and marked tendency to recurrence.

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