scholarly journals Evidence for Copper-dioxygen Reactivity during α-Synuclein Fibril Formation

2010 ◽  
Vol 132 (19) ◽  
pp. 6636-6637 ◽  
Author(s):  
Heather R. Lucas ◽  
Serena DeBeer ◽  
Myoung-Soon Hong ◽  
Jennifer C. Lee
Keyword(s):  
Fibril Formation ◽  
Dioxygen Reactivity ◽  
Copper Dioxygen

scholarly journals Observation of a CuII2(μ-1,2-peroxo)/CuIII2(μ-oxo)2Equilibrium and its Implications for Copper-Dioxygen Reactivity

2014 ◽  
Vol 53 (19) ◽  
pp. 4935-4939 ◽  
Author(s):  
Matthew T. Kieber-Emmons ◽  
Jake W. Ginsbach ◽  
Patrick K. Wick ◽  
Heather R. Lucas ◽  
Matthew E. Helton ◽  
...  
Keyword(s):  
Dioxygen Reactivity ◽  
Copper Dioxygen

Observation of a CuII2(μ-1,2-peroxo)/CuIII2(μ-oxo)2Equilibrium and its Implications for Copper-Dioxygen Reactivity

2014 ◽  
Vol 126 (19) ◽  
pp. 5035-5039 ◽  
Author(s):  
Matthew T. Kieber-Emmons ◽  
Jake W. Ginsbach ◽  
Patrick K. Wick ◽  
Heather R. Lucas ◽  
Matthew E. Helton ◽  
...  
Keyword(s):  
Dioxygen Reactivity ◽  
Copper Dioxygen

Ligand Macrocycle Structural Effects on Copper−Dioxygen Reactivity

2000 ◽  
Vol 39 (18) ◽  
pp. 4059-4072 ◽  
Author(s):  
Bernice M. T. Lam ◽  
Jason A. Halfen ◽  
Victor G. Young, ◽  
John R. Hagadorn ◽  
Patrick L. Holland ◽  
...  
Keyword(s):  
Structural Effects ◽  
Dioxygen Reactivity ◽  
Copper Dioxygen

Modulation of the Copper-Dioxygen Reactivity by Stereochemical Effect of Tetradentate Tripodal Ligands

2002 ◽  
Vol 31 (3) ◽  
pp. 416-417 ◽  
Author(s):  
Hideki Hayashi ◽  
Kounosuke Uozumi ◽  
Shuhei Fujinami ◽  
Shigenori Nagatomo ◽  
Kazushi Shiren ◽  
...  
Keyword(s):  
Tripodal Ligands ◽  
Dioxygen Reactivity ◽  
Copper Dioxygen

Tuning Copper−Dioxygen Reactivity and Exogenous Substrate Oxidations via Alterations in Ligand Electronics

2003 ◽  
Vol 125 (3) ◽  
pp. 634-635 ◽  
Author(s):  
Christiana Xin Zhang ◽  
Hong-Chang Liang ◽  
Eun-il Kim ◽  
Jason Shearer ◽  
Matthew E. Helton ◽  
...  
Keyword(s):  
Exogenous Substrate ◽  
Dioxygen Reactivity ◽  
Copper Dioxygen

Modeling Copper-Dioxygen Reactivity in Proteins: Aliphatic C-H Bond Activation by a New Dicopper(II)-Peroxo Complex

1994 ◽  
Vol 116 (21) ◽  
pp. 9785-9786 ◽  
Author(s):  
Samiran Mahapatra ◽  
Jason A. Halfen ◽  
Elizabeth C. Wilkinson ◽  
Lawrence Que ◽  
William B. Tolman
Keyword(s):  
Bond Activation ◽  
Peroxo Complex ◽  
Dioxygen Reactivity ◽  
Copper Dioxygen

Immunocytochemical Localization of Amyloid Protein AA in the “Dense Fibrillar Inclusions” of the Reticuloendothelical Cells

1977 ◽  
Vol 35 ◽  
pp. 438-439
Author(s):  
T. Shirahama ◽  
M. Skinner ◽  
A.S. Cohen
Keyword(s):  
Amyloid Fibril ◽  
Close Association ◽  
Gel Filtration ◽  
Fibril Formation ◽  
Amyloid Protein ◽  
Electron Microscopic ◽  
Amyloid Deposits ◽  
Amyloid Fibril Formation ◽  
Electron Microscopic Technique ◽  
Lysosomal System

A1thought the mechanisms of amyloidogenesis have not been entirely clarified, proteolysis of the parent proteins may be one of the important steps in the amyloid fibril formation. Recently, we reported that "dense fibrillar inclusions" (DFI), which had the characteristics of lysosomes and contained organized fibrillar profiles as well, were observed in the reticuloendothelial cells in close association with the foci of new amyloid deposits. We considered the findings as evidence for the involvement of lysosomal system in amyloid fibril formation (l). In the present study, we attempted to determine the identity of the contents of the DFI by the use of antisera against the amyloid protein (AA) and an immuno-electron microscopic technique.Amyloidosis was induced in CBA/J mice by daily injections of casein (l). AA was isolated from amyloid-laden spleens by gel filtration and antibody to it was produced in rabbits (2). For immunocytochemistry, the unlabeled antibody enzyme method (3) was employed.

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