Imidazolium Carboxylates as Versatile and Selective N-Heterocyclic Carbene Transfer Agents:  Synthesis, Mechanism, and Applications

2007 ◽  
Vol 129 (42) ◽  
pp. 12834-12846 ◽  
Author(s):  
Adelina M. Voutchkova ◽  
Marta Feliz ◽  
Eric Clot ◽  
Odile Eisenstein ◽  
Robert H. Crabtree
Keyword(s):  
Synthesis Mechanism ◽  
Carbene Transfer ◽  
Transfer Agents

NHC–manganese(i) complexes as carbene transfer agents

2009 ◽  
pp. 6999 ◽  
Author(s):  
Javier Ruiz ◽  
Ángela Berros ◽  
Bernabé F. Perandones ◽  
Marilín Vivanco
Keyword(s):  
Carbene Transfer ◽  
Transfer Agents

Facile Synthesis of Silver(I)−Carbene Complexes. Useful Carbene Transfer Agents

1998 ◽  
Vol 17 (5) ◽  
pp. 972-975 ◽  
Author(s):  
Harrison M. J. Wang ◽  
Ivan J. B. Lin
Keyword(s):  
Facile Synthesis ◽  
Carbene Complexes ◽  
Carbene Transfer ◽  
Transfer Agents

General Cyclopropane Assembly via Enantioselective Redox-Active Carbene Transfer to Aliphatic Olefins

2018 ◽  
Author(s):  
Marc Montesinos-Magraner ◽  
Matteo Costantini ◽  
Rodrigo Ramirez-Contreras ◽  
Michael E. Muratore ◽  
Magnus J. Johansson ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Asymmetric Synthesis ◽  
Chemical Space ◽  
Synthetic Approach ◽  
Asymmetric Cyclopropanation ◽  
Redox Active ◽  
Wide Range ◽  
Leaving Group ◽  
Stereoelectronic Properties ◽  
Carbene Transfer

Asymmetric cyclopropane synthesis currently requires bespoke strategies, methods, substrates and reagents, even when targeting similar compounds. This limits the speed and chemical space available for discovery campaigns. Here we introduce a practical and versatile diazocompound, and we demonstrate its performance in the first unified asymmetric synthesis of functionalized cyclopropanes. We found that the redox-active leaving group in this reagent enhances the reactivity and selectivity of geminal carbene transfer. This effect enabled the asymmetric cyclopropanation of a wide range of olefins including unactivated aliphatic alkenes, enabling the 3-step total synthesis of (–)-dictyopterene A. This unified synthetic approach delivers high enantioselectivities that are independent of the stereoelectronic properties of the functional groups transferred. Our results demonstrate that orthogonally-differentiated diazocompounds are viable and advantageous equivalents of single-carbon chirons<i>.</i>

4H-1,3-Benzothiazin-4-one a Promising Class Against MDR/XDR-TB

2019 ◽  
Vol 19 (8) ◽  
pp. 567-578 ◽  
Author(s):  
Marcus Vinicius Nora de Souza ◽  
Thais Cristina Mendonça Nogueira
Keyword(s):  
Treatment Time ◽  
Public Health Problem ◽  
New Drugs ◽  
Global Public Health ◽  
Synthesis Mechanism ◽  
Highly Active ◽  
Latent Disease ◽  
Resistant Strains ◽  
Chemical Class ◽  
Global Public Health Problem

Nowadays, tuberculosis (TB) is an important global public health problem, being responsible for millions of TB-related deaths worldwide. Due to the increased number of cases and resistance of Mycobacterium tuberculosis to all drugs used for the treatment of this disease, we desperately need new drugs and strategies that could reduce treatment time with fewer side effects, reduced cost and highly active drugs against resistant strains and latent disease. Considering that, 4H-1,3-benzothiazin-4-one is a promising class of antimycobacterial agents in special against TB-resistant strains being the aim of this review the discussion of different aspects of this chemical class such as synthesis, mechanism of action, medicinal chemistry and combination with other drugs.

Nanostructured Pb(S, O) Films: Synthesis, Mechanism of Deposition, and Optical Properties

2020 ◽  
Vol 94 (12) ◽  
pp. 2421-2427
Author(s):  
R. Kh. Saryeva ◽  
N. S. Kozhevnikova ◽  
L. N. Maskaeva ◽  
V. F. Markov ◽  
V. I. Voronin ◽  
...  
Keyword(s):  
Optical Properties ◽  
Synthesis Mechanism

scholarly journals Homoleptic and heteroleptic bis-NHC Cu(i) complexes as carbene transfer reagents

2016 ◽  
Vol 45 (12) ◽  
pp. 4970-4973 ◽  
Author(s):  
Orlando Santoro ◽  
Faïma Lazreg ◽  
David B. Cordes ◽  
Alexandra M. Z. Slawin ◽  
Catherine S. J. Cazin
Keyword(s):  
Carbene Transfer

Homo- and heteroleptic bis-NHC copper(i) complexes have been efficiently used as carbene transfer reagents to Au and Pd.

Sign in / Sign up

Export Citation Format

Share Document