scholarly journals Modulation of Bacterial Quorum Sensing with Synthetic Ligands:  Systematic Evaluation ofN-Acylated Homoserine Lactones in Multiple Species and New Insights into Their Mechanisms of Action

2007 ◽  
Vol 129 (44) ◽  
pp. 13613-13625 ◽  
Author(s):  
Grant D. Geske ◽  
Jennifer C. O'Neill ◽  
David M. Miller ◽  
Margrith E. Mattmann ◽  
Helen E. Blackwell
Keyword(s):  
Quorum Sensing ◽  
Mechanisms Of Action ◽  
Systematic Evaluation ◽  
Homoserine Lactones ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum ◽  
Multiple Species ◽  
Acylated Homoserine Lactones

Inactivation of bacterial quorum sensing signals N-acyl homoserine lactones is widespread in yeasts

2018 ◽  
Vol 122 (1) ◽  
pp. 52-62 ◽  
Author(s):  
Ana Carolina del V. Leguina ◽  
Carolina Nieto ◽  
Hipólito F. Pajot ◽  
Elisa V. Bertini ◽  
Walter Mac Cormack ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Homoserine Lactones ◽  
Acyl Homoserine Lactones ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum ◽  
Quorum Sensing Signals

N-Sulfonyl Homoserine Lactones as Antagonists of Bacterial Quorum Sensing.

ChemInform ◽  
2005 ◽  
Vol 36 (5) ◽  
Author(s):  
Sandra Castang ◽  
Bernard Chantegrel ◽  
Christian Deshayes ◽  
Rene Dolmazon ◽  
Patrice Gouet ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Homoserine Lactones ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

scholarly journals The GCR1 and GPA1 Participate in Promotion of Arabidopsis Primary Root Elongation Induced by N-Acyl-Homoserine Lactones, the Bacterial Quorum-Sensing Signals

2012 ◽  
Vol 25 (5) ◽  
pp. 677-683 ◽  
Author(s):  
Fang Liu ◽  
Ziriu Bian ◽  
Zhenhua Jia ◽  
Qian Zhao ◽  
Shuishan Song
Keyword(s):  
Quorum Sensing ◽  
Root Elongation ◽  
Primary Root ◽  
Homoserine Lactone ◽  
Collective Behaviors ◽  
Homoserine Lactones ◽  
Acyl Homoserine Lactones ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum ◽  
Quorum Sensing Signals

Many gram-negative bacteria use N-acyl-homoserine lactones (AHL) as quorum-sensing signals to coordinate their collective behaviors. Accumulating evidence indicates that plants can respond to AHL. However, little is known about the molecular mechanism of plants reacting to these bacterial signals. In this study, we show that the treatment of Arabidopsis roots with N-3-oxo-hexanoyl-homoserine lactone (3OC6-HSL) and N-3-oxo-octanoyl-homoserine lactone (3OC8-HSL) resulted in significant root elongation. The genetic analysis revealed that the T-DNA insertional mutants of gcr1, encoding a G-protein-coupled receptor GCR1, were insensitive to 3OC6-HSL or 3OC8-HSL in assays of root growth. The loss-of-function mutants of the sole canonical Gα subunit GPA1 showed no response to AHL promotion of root elongation whereas Gα gain-of-function plants overexpressing either the wild type or a constitutively active version of Arabidopsis Gα exhibited the exaggerated effect on root elongation caused by AHL. Furthermore, the expression of GCR1 and GPA1 were significantly upregulated after plants were contacted with both AHL. Taken together, our results suggest that GCR1 and GPA1 are involved in AHL-mediated elongation of Arabidopsis roots. This provides insight into the mechanism of plant responses to bacterial quorum-sensing signals.

scholarly journals Perspective: Methionine Restriction–Induced Longevity—A Possible Role for Inhibiting the Synthesis of Bacterial Quorum Sensing Molecules

2020 ◽  
Vol 11 (4) ◽  
pp. 773-783
Author(s):  
Peng Bin ◽  
Congrui Zhu ◽  
Shaojuan Liu ◽  
Zhendong Li ◽  
Wenkai Ren ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Quorum Sensing ◽  
Stress Resistance ◽  
Lifespan Extension ◽  
Oxidative Stress Resistance ◽  
Methionine Restriction ◽  
Igf I ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum ◽  
Multiple Species

ABSTRACT Methionine restriction (MR) extends lifespans in multiple species through mechanisms that include enhanced oxidative stress resistance and inhibition of insulin/insulin-like growth factor I (IGF-I) signaling. Methionine and S-adenosylmethionine (SAM) are the essential precursors of bacterial quorum sensing (QS) molecules, and therefore, MR might also affect bacterial communication to prevent enteric bacterial infection as well as chronic inflammation, which contributes to lifespan prolongation. Here, we discuss the influence of MR on oxidative stress resistance and inhibition of insulin/IGF-I cell signaling and further propose a potential mechanism involving bacterial QS inhibition for lifespan extension. Unraveling the connection between MR and inhibition of QS provides new strategies for combating infectious diseases, resulting in enriched understanding of MR-induced lifespan extension.

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