scholarly journals Soluble Single-Walled Carbon Nanotubes as Longboat Delivery Systems for Platinum(IV) Anticancer Drug Design

2007 ◽  
Vol 129 (27) ◽  
pp. 8438-8439 ◽  
Author(s):  
Rodney P. Feazell ◽  
Nozomi Nakayama-Ratchford ◽  
Hongjie Dai ◽  
Stephen J. Lippard
Keyword(s):  
Carbon Nanotubes ◽  
Drug Design ◽  
Anticancer Drug ◽  
Single Walled Carbon Nanotubes ◽  
Delivery Systems ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

Preferred Position and Orientation of Anticancer Drug Cisplatin During Encapsulation Into Single-Walled Carbon Nanotubes

2012 ◽  
Vol 3 (1) ◽  
Author(s):  
R. Ansari ◽  
E. Kazemi ◽  
E. Mahmoudinezhad ◽  
F. Sadeghi
Keyword(s):  
Carbon Nanotubes ◽  
Side Effects ◽  
Anticancer Drug ◽  
Equilibrium Condition ◽  
Hybrid Approach ◽  
Single Walled Carbon Nanotubes ◽  
Drug Carriers ◽  
Single Walled Carbon ◽  
Chemotherapy Drugs ◽  
Walled Carbon Nanotubes

Cisplatin is one of the most widely prescribed chemotherapy drugs to treat different types of cancers. However, this anticancer drug has a number of side effects such as kidney and nerve damages, anaphylactic reactions, hearing loss, nausea, and vomiting that strongly restrict its function. In the present study, single-walled carbon nanotubes (SWCNTs) are used as protective drug carriers which can decrease these severe side effects to some extent. Using the hybrid discrete-continuum model in conjunction with Lennard-Jones potential, new semi-analytical expressions in terms of single integrals are given to evaluate van der Waals (vdW) potential energy and interaction force between an offset cisplatin and a SWCNT. In addition, molecular dynamics (MD) simulations are conducted to validate the results of such a hybrid approach. The preferred location and orientation of cisplatin while entering SWCNTs are determined. It is shown that the equilibrium condition of the drug may be affected by the radius of nanotube, the orientation of cisplatin, and the distance between the central molecule of the drug (Pt) and the left end of nanotube. Furthermore, the influence of equilibrium condition on the distributions of vdW interactions is investigated.

scholarly journals Self-Assembled Supramolecular Ribbon-Like Structures Complexed to Single Walled Carbon Nanotubes as Possible Anticancer Drug Delivery Systems

2019 ◽  
Vol 20 (9) ◽  
pp. 2064 ◽  
Author(s):  
Anna Jagusiak ◽  
Katarzyna Chłopaś ◽  
Grzegorz Zemanek ◽  
Małgorzata Jemioła-Rzemińska ◽  
Barbara Piekarska ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Anticancer Drug ◽  
Triple System ◽  
Single Walled Carbon Nanotubes ◽  
Drug Binding ◽  
Single Walled Carbon ◽  
Anticancer Drug Delivery ◽  
Self Assembled ◽  
Walled Carbon Nanotubes

Designing an effective targeted anticancer drug delivery method is still a big challenge, since chemotherapeutics often cause a variety of undesirable side effects affecting normal tissues. This work presents the research on a novel system consisting of single walled carbon nanotubes (SWNT), dispersed with Congo Red (CR), a compound that forms self-assembled ribbon-like structures (SRLS) and anticancer drug doxorubicin (DOX). SWNT provide a large surface for binding of planar aromatic compounds, including drugs, while CR supramolecular ribbon-like assemblies can be intercalated by drugs, like anthracycline rings containing DOX. The mechanism of interactions in SWNT–CR–DOX triple system was proposed based on electrophoretic, spectral, Dynamic Light Scattering and scanning electron microscopy analyzes. The profile of drug release from the investigated system was evaluated using dialysis and Differential Scanning Calorimetry. The results indicate that ribbon-like supramolecular structures of CR bind to SWNT surface forming SWNT–CR complexes which finally bind DOX. The high amount of nanotube-bound CR greatly increases the capacity of the carrier for the drug. The high capacity for drug binding and possible control of its release (through pH changes) in the analyzed system may result in prolonged and localized drug action. The proposed SWNT–CR–DOX triple system meets the basic criteria that justifies its further research as a potential drug carrier.

Purity Evaluation of Single-Walled Carbon Nanotubes Using Thermogravimetric Analysis

2013 ◽  
Vol 51 (2) ◽  
pp. 137-144
Author(s):  
Naesung Lee ◽  
Jeung Choon Goak ◽  
Tae Yang Kim ◽  
Jongwan Jung ◽  
Young-Soo Seo ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Thermogravimetric Analysis ◽  
Single Walled Carbon Nanotubes ◽  
Single Walled Carbon ◽  
Purity Evaluation ◽  
Walled Carbon Nanotubes

Hybrid Bioactive Hydrogels Containing Single-Walled Carbon Nanotubes Covalently Integrated via Strain-Promoted Azide-Alkyne Cycloaddition

2012 ◽  
Vol 2 (2) ◽  
pp. 200-209 ◽  
Author(s):  
Jurgen Bachl ◽  
Thimo Huber ◽  
Dennis Kuhbeck ◽  
Eva-Maria Schon ◽  
Gabriele Brunner ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Single Walled Carbon Nanotubes ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes
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