scholarly journals Spectroscopic and Electronic Structure Study of the Enzyme−Substrate Complex of Intradiol Dioxygenases:  Substrate Activation by a High-Spin Ferric Non-heme Iron Site

2007 ◽  
Vol 129 (7) ◽  
pp. 1944-1958 ◽  
Author(s):  
Monita Y. M. Pau ◽  
Mindy I. Davis ◽  
Allen M. Orville ◽  
John D. Lipscomb ◽  
Edward I. Solomon
Keyword(s):  
Electronic Structure ◽  
High Spin ◽  
Structure Study ◽  
Heme Iron ◽  
Iron Site ◽  
Substrate Complex ◽  
Enzyme Substrate ◽  
Non Heme Iron ◽  
Substrate Activation

Transient-Phase and Steady-State Kinetics for Enzyme Activation

1973 ◽  
Vol 51 (6) ◽  
pp. 806-814 ◽  
Author(s):  
Nasrat H. Hijazi ◽  
Keith J. Laidler
Keyword(s):  
Steady State ◽  
Kinetic Data ◽  
Enzyme Activation ◽  
Transient Phase ◽  
Time Curve ◽  
Substrate Complex ◽  
Enzyme Substrate ◽  
Substrate Activation ◽  
Steady State Kinetics ◽  
Special Case

A non-steady-state analysis has been worked out for two mechanisms in which an activator Q can become attached to an enzyme–substrate complex EA, the species EAQ breaking down more rapidly than EA. It is shown that if EAQ breaks down into EQ + product there can be no steady state. If, however, EAQ breaks down into E + Q + product, the transient phase is followed by a steady state in which the product versus time curve is linear. A special case of this mechanism is when Q is the substrate (substrate activation). Some published kinetic data on carboxypeptidase are analyzed with reference to the equations derived.

ChemInform Abstract: Geometric and Electronic Structure/Function Correlations in Non-heme Iron Enzymes

ChemInform ◽  
2010 ◽  
Vol 31 (13) ◽  
pp. no-no
Author(s):  
Edward I. Solomon ◽  
Thomas C. Brunold ◽  
Mindy I. Davis ◽  
Jyllian N. Kemsley ◽  
Sang-Kyu Lee ◽  
...  
Keyword(s):  
Electronic Structure ◽  
Structure Function ◽  
Heme Iron ◽  
Non Heme Iron ◽  
Iron Enzymes

scholarly journals Geometric and Electronic Structure Contributions to Function in Non-heme Iron Enzymes

2013 ◽  
Vol 46 (11) ◽  
pp. 2725-2739 ◽  
Author(s):  
Edward I. Solomon ◽  
Kenneth M. Light ◽  
Lei V. Liu ◽  
Martin Srnec ◽  
Shaun D. Wong
Keyword(s):  
Electronic Structure ◽  
Heme Iron ◽  
Non Heme Iron ◽  
Iron Enzymes

scholarly journals Geometric and Electronic Structure of the Mn(IV)Fe(III) Cofactor in Class Ic Ribonucleotide Reductase: Correlation to the Class Ia Binuclear Non-Heme Iron Enzyme

2013 ◽  
Vol 135 (46) ◽  
pp. 17573-17584 ◽  
Author(s):  
Yeonju Kwak ◽  
Wei Jiang ◽  
Laura M. K. Dassama ◽  
Kiyoung Park ◽  
Caleb B. Bell ◽  
...  
Keyword(s):  
Electronic Structure ◽  
Ribonucleotide Reductase ◽  
Heme Iron ◽  
Non Heme Iron

Interactions of mononuclear non-heme iron sites with dioxygen: Studies on electronic structure and reactivity

2003 ◽  
Vol 96 (1) ◽  
pp. 124
Author(s):  
Andrea Decker ◽  
Nicolai Lehnert ◽  
Marina S. Chow ◽  
Edward I. Solomon
Keyword(s):  
Electronic Structure ◽  
Heme Iron ◽  
Non Heme Iron

Electronic structure and reactivity of a high valent non-heme iron-oxo intermediate

1993 ◽  
Vol 51 (1-2) ◽  
pp. 100
Author(s):  
Hiroshi Fujii ◽  
Randolph A. Leising ◽  
Yanhong Dong ◽  
Li-June Ming ◽  
Zhigang Wang ◽  
...  
Keyword(s):  
Electronic Structure ◽  
Heme Iron ◽  
Non Heme Iron ◽  
High Valent
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