Effect of Surface Functionalization of MCM-41-Type Mesoporous Silica Nanoparticles on the Endocytosis by Human Cancer Cells

2006 ◽  
Vol 128 (46) ◽  
pp. 14792-14793 ◽  
Author(s):  
Igor Slowing ◽  
Brian G. Trewyn ◽  
Victor S.-Y. Lin
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Surface Functionalization ◽  
Human Cancer ◽  
Mesoporous Silica Nanoparticles ◽  
Human Cancer Cells ◽  
Mcm 41 ◽  
Effect Of Surface

Uptake of Functionalized Mesoporous Silica Nanoparticles by Human Cancer Cells

2010 ◽  
Vol 10 (4) ◽  
pp. 2314-2324 ◽  
Author(s):  
Matthieu Fisichella ◽  
Hinda Dabboue ◽  
Sanjib Bhattacharyya ◽  
Gérald Lelong ◽  
Marie-Louise Saboungi ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Human Cancer ◽  
Mesoporous Silica Nanoparticles ◽  
Human Cancer Cells ◽  
Functionalized Mesoporous Silica

scholarly journals Loading of Cisplatin into Mesoporous Silica Nanoparticles: Effect of Surface Functionalization

Langmuir ◽  
2019 ◽  
Vol 35 (27) ◽  
pp. 8984-8995 ◽  
Author(s):  
Mathieu Varache ◽  
Igor Bezverkhyy ◽  
Guy Weber ◽  
Lucien Saviot ◽  
Rémi Chassagnon ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Functionalization ◽  
Mesoporous Silica Nanoparticles ◽  
Effect Of Surface

scholarly journals Construction of Boronophenylalanine-Loaded Biodegradable Periodic Mesoporous Organosilica Nanoparticles for BNCT Cancer Therapy

2021 ◽  
Vol 22 (5) ◽  
pp. 2251
Author(s):  
Fuyuhiko Tamanoi ◽  
Shanmugavel Chinnathambi ◽  
Mathilde Laird ◽  
Aoi Komatsu ◽  
Albane Birault ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Cancer Cells ◽  
Human Cancer ◽  
Mesoporous Silica Nanoparticles ◽  
Tumor Model ◽  
Periodic Mesoporous Organosilica ◽  
Human Cancer Cells ◽  
Mesoporous Organosilica ◽  
Tumor Accumulation

Biodegradable periodic mesoporous organosilica (BPMO) has recently emerged as a promising type of mesoporous silica-based nanoparticle for biomedical applications. Like mesoporous silica nanoparticles (MSN), BPMO possesses a large surface area where various compounds can be attached. In this work, we attached boronophenylalanine (10BPA) to the surface and explored the potential of this nanomaterial for delivering boron-10 for use in boron neutron capture therapy (BNCT). This cancer therapy is based on the principle that the exposure of boron-10 to thermal neutron results in the release of a-particles that kill cancer cells. To attach 10BPA, the surface of BPMO was modified with diol groups which facilitated the efficient binding of 10BPA, yielding 10BPA-loaded BPMO (10BPA-BPMO). Surface modification with phosphonate was also carried out to increase the dispersibility of the nanoparticles. To investigate this nanomaterial’s potential for BNCT, we first used human cancer cells and found that 10BPA-BPMO nanoparticles were efficiently taken up into the cancer cells and were localized in perinuclear regions. We then used a chicken egg tumor model, a versatile and convenient tumor model used to characterize nanomaterials. After observing significant tumor accumulation, 10BPA-BPMO injected chicken eggs were evaluated by irradiating with neutron beams. Dramatic inhibition of the tumor growth was observed. These results suggest the potential of 10BPA-BPMO as a novel boron agent for BNCT.

scholarly journals Targeted delivery of mesoporous silica nanoparticles loaded monastrol into cancer cells: an in vitro study

2017 ◽  
Vol 7 (8) ◽  
pp. 549-555 ◽  
Author(s):  
Huzaifa Hanif ◽  
Samina Nazir ◽  
Kehkashan Mazhar ◽  
Muhammad Waseem ◽  
Shazia Bano ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
In Vitro Study ◽  
Vitro Study

Gated Mesoporous Silica Nanoparticles for the Controlled Delivery of Drugs in Cancer Cells

Langmuir ◽  
2015 ◽  
Vol 31 (12) ◽  
pp. 3753-3762 ◽  
Author(s):  
Cristina Giménez ◽  
Cristina de la Torre ◽  
Mónica Gorbe ◽  
Elena Aznar ◽  
Félix Sancenón ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Delivery
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