All-Carbon Quaternary Centers via Catalytic Asymmetric Hydrovinylation. New Approaches to the Exocyclic Side Chain Stereochemistry Problem

2006 ◽  
Vol 128 (17) ◽  
pp. 5620-5621 ◽  
Author(s):  
Aibin Zhang ◽  
T. V. RajanBabu
Keyword(s):  
Side Chain ◽  
Quaternary Centers ◽  
New Approaches ◽  
Catalytic Asymmetric ◽  
Asymmetric Hydrovinylation

The design of a spiro-pyrrolidine organocatalyst and its application to catalytic asymmetric Michael addition for the construction of all-carbon quaternary centers

2015 ◽  
Vol 51 (49) ◽  
pp. 9979-9982 ◽  
Author(s):  
Jin-Miao Tian ◽  
Yong-Hai Yuan ◽  
Yong-Qiang Tu ◽  
Fu-Min Zhang ◽  
Xiao-Bo Zhang ◽  
...  
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Silyl Ether ◽  
Michael Addition Reaction ◽  
Quaternary Centers ◽  
Asymmetric Michael Addition ◽  
Catalytic Asymmetric

A novel chiral spiro-pyrrolidine silyl ether organocatalyst has been designed and applied to an asymmetric Michael addition reaction.

scholarly journals Acyclic quaternary centers from asymmetric conjugate addition of alkylzirconium reagents to linear trisubstituted enones

2017 ◽  
Vol 8 (1) ◽  
pp. 641-646 ◽  
Author(s):  
Zhenbo Gao ◽  
Stephen P. Fletcher
Keyword(s):  
Conjugate Addition ◽  
Synthetic Methods ◽  
Quaternary Centers ◽  
Cyclic Systems ◽  
Catalytic Asymmetric ◽  
Selective Formation

Synthetic methods for the selective formation of all carbon quaternary centres in non-cyclic systems are rare. Here we report highly enantioselective Cu-catalytic asymmetric conjugate addition of alkylzirconium species to twelve different acyclic trisubstituted enones.

Formation of a Chiral Quaternary Centers via Asymmetric Hydrovinylation

Synfacts ◽  
2008 ◽  
Vol 2008 (7) ◽  
pp. 0719-0719
Author(s):  
T. RajanBabu ◽  
C. Smith
Keyword(s):  
Quaternary Centers ◽  
Asymmetric Hydrovinylation

New Approaches to Branched β-Amino α-Hydroxy Acids, Taxol Side-chain Analogs

2008 ◽  
Vol 63 (4) ◽  
pp. 431-446 ◽  
Author(s):  
Feng Li ◽  
Zhao-Ming Li ◽  
Hua Yang ◽  
Volker Jäger
Keyword(s):  
Grignard Reagent ◽  
The Other ◽  
Side Chain ◽  
Hydroxy Acids ◽  
New Approaches ◽  
Stereoselective Addition

AbstractThe phenylisothreonine derivatives, taxol side-chain analogs, were synthesized by two routes, one based on the highly stereoselective addition of a phenyl Grignard reagent to the L-threose-derived nitrone 7, and the other using asymmetric α-alkoxyallylation of the ketimine 20 with chiral allyl boron reagents.

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