One-Electron Oxidation of DNA Oligomers That Lack Guanine:  Reaction and Strand Cleavage at Remote Thymines by Long-Distance Radical Cation Hopping

2006 ◽  
Vol 128 (16) ◽  
pp. 5346-5347 ◽  
Author(s):  
Abraham Joy ◽  
Avik K. Ghosh ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Long Distance ◽  
Dna Oligomers ◽  
Oxidation Of Dna

Effect of positively charged backbone groups on radical cation migration and reaction in duplex DNA

2011 ◽  
Vol 89 (3) ◽  
pp. 326-330 ◽  
Author(s):  
Sriram Kanvah ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Dna Analysis ◽  
Duplex Dna ◽  
Charge Migration ◽  
Electron Hole ◽  
Dna Oligomers ◽  
Phosphodiester Backbone ◽  
Cation Migration ◽  
Covalently Linked ◽  
Positively Charged

A series of DNA oligomers were prepared that contain guanidinium linkages (positively charged) positioned selectively in place of and among the normal negatively charged phosphodiester backbone groups of duplex DNA. One-electron oxidation of these DNA oligomers by UV irradiation of a covalently linked anthraquinone group generates a radical cation (electron “hole”) that migrates by hopping through the DNA and is trapped at reactive sites, GG steps, to form mutated bases that are detected by strand cleavage after subsequent piperidine treatment of the irradiated DNA. Analysis of the strand cleavage pattern reveals that guanidinium substitution in these oligomers does not measurably affect the charge migration rate but it does inhibit reaction at nearby guanines.

Long-Distance Radical Cation Migration in Z-Form DNA

2001 ◽  
Vol 123 (27) ◽  
pp. 6696-6697 ◽  
Author(s):  
Ibrahim M. Abdou ◽  
Valerie Sartor ◽  
Huachuan Cao ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Long Distance ◽  
Cation Migration
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