An Efficient Route to Well-Defined Macrocyclic Polymers via “Click” Cyclization

2006 ◽  
Vol 128 (13) ◽  
pp. 4238-4239 ◽  
Author(s):  
Boyd A. Laurent ◽  
Scott M. Grayson
Keyword(s):  
Efficient Route ◽  
Macrocyclic Polymers

Carbon Monoxide Related Reductions

INEOS OPEN ◽  
2020 ◽  
Vol 3 ◽  
Author(s):  
O. I. Afanasyev ◽  
◽  
D. Chusov ◽  
Keyword(s):  
Organic Chemistry ◽  
Carbon Monoxide ◽  
Reducing Agent ◽  
Current Development ◽  
Efficient Route ◽  
Development Prospects

Carbon monoxide is a unique reducing agent that is only gaining popularity in organic chemistry. This review highlights the main approaches to the application of CO as a reducing agent, summarizes and critically analyzes the key trends in this field, and describes the current development prospects. Potentially the most selective and efficient route for the realization of these processes is demonstrated.

Palladium Nanowire Thin Films via Template Growth

2003 ◽  
Vol 775 ◽  
Author(s):  
Donghai Wang ◽  
David T. Johnson ◽  
Byron F. McCaughey ◽  
J. Eric Hampsey ◽  
Jibao He ◽  
...  
Keyword(s):  
Thin Film ◽  
Electron Microscopy ◽  
Thin Films ◽  
X Ray Diffraction ◽  
X Ray ◽  
Transmission Electron ◽  
Conductive Substrate ◽  
Palladium Nanowires ◽  
Efficient Route ◽  
Silica Thin Film

AbstractPalladium nanowires have been electrodeposited into mesoporous silica thin film templates. Palladium continually grows and fills silica mesopores starting from a bottom conductive substrate, providing a ready and efficient route to fabricate a macroscopic palladium nanowire thin films for potentially use in fuel cells, electrodes, sensors, and other applications. X-ray diffraction (XRD) and transmission electron microscopy (TEM) indicate it is possible to create different nanowire morphology such as bundles and swirling mesostructure based on the template pore structure.

Efficient Route for Synthesis of Enamines from 1,3-Alkyl-2-Thioxodihydropyrimidine-4,6(1H,5H)-dione Enols

2019 ◽  
Vol 16 (7) ◽  
pp. 538-540
Author(s):  
Anamika Sharma ◽  
Zainab M. Almarhoon ◽  
Ayman El-Faham ◽  
Beatriz G. de la Torre ◽  
Fernando Albericio
Keyword(s):  
Ammonium Chloride ◽  
Thiobarbituric Acid ◽  
Acid Acid ◽  
Efficient Route ◽  
Harsh Conditions

Here we report a greener approach for the synthesis of enamines from enols of 1,3-alkyl-2- thioxodihydropyrimidine-4,6(1H,5H)-dione (thiobarbituric acid) acid using ammonium chloride and ethanol as solvents. This protocol removes the need for catalysts or harsh conditions.

scholarly journals Catalytic Antioxidant Activity of Bis-Aniline-Derived Diselenides as GPx Mimics

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4446
Author(s):  
Giancarlo V. Botteselle ◽  
Welman C. Elias ◽  
Luana Bettanin ◽  
Rômulo F. S. Canto ◽  
Drielly N. O. Salin ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Hydrogen Bond ◽  
Electronic Properties ◽  
Partial Charge ◽  
Amino Group ◽  
Diphenyl Diselenide ◽  
Charge Delocalization ◽  
Ipso Substitution ◽  
Efficient Route ◽  
Catalytic Performances

Herein, we describe a simple and efficient route to access aniline-derived diselenides and evaluate their antioxidant/GPx-mimetic properties. The diselenides were obtained in good yields via ipso-substitution/reduction from the readily available 2-nitroaromatic halides (Cl, Br, I). These diselenides present GPx-mimetic properties, showing better antioxidant activity than the standard GPx-mimetic compounds, ebselen and diphenyl diselenide. DFT analysis demonstrated that the electronic properties of the substituents determine the charge delocalization and the partial charge on selenium, which correlate with the catalytic performances. The amino group concurs in the stabilization of the selenolate intermediate through a hydrogen bond with the selenium.

scholarly journals A Characterization Study of Morphology and Properties of Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBH)/Aloe Vera Fibers Biocomposites: Effect of Fiber Surface Treatments

Proceedings ◽  
2020 ◽  
Vol 69 (1) ◽  
pp. 38
Author(s):  
Celia Idres ◽  
Mustapha Kaci ◽  
Nadjet Dehouche ◽  
Idris Zembouai ◽  
Stéphane Bruzaud
Keyword(s):  
Thermal Stability ◽  
Surface Morphology ◽  
Water Absorption ◽  
Loss Modulus ◽  
Aloe Vera ◽  
Fiber Surface ◽  
Complex Viscosity ◽  
Absorption Capacity ◽  
Characterization Study ◽  
Efficient Route

This paper aims to investigate the effect of different chemical modifications of biocomposites based on poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBH) and aloe vera bio-fibers incorporated at 20 wt%. The fiber surface was modified with alkaline, organosilanes, and combined alkaline/organosilanes. Surface morphology, thermal stability, water absorption capacity, and rheological behavior of the modified biocomposite materials were studied, and the results compared to both unmodified biocomposites and neat PHBH. The study showed that the modified biocomposites with both alkaline and organosilanes exhibited an improved surface morphology, resulting in a good fiber/matrix interfacial adhesion. As a result, increases in complex viscosity, storage modulus, and loss modulus were observed, whereas water absorption was reduced. Thermal stability remained almost unchanged, with the exception of the biocomposite treated with alkaline, where this property decreased significantly. Finally, the coupling of alkaline and organosilane modification is an efficient route to enhance the properties of PHBH biocomposites.

scholarly journals Nanocrystal-Loaded Micelles for the Enhanced In Vivo Circulation of Docetaxel

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4481
Author(s):  
Meng Cheng ◽  
Qiaoming Liu ◽  
Tiantian Gan ◽  
Yuanying Fang ◽  
Pengfei Yue ◽  
...  
Keyword(s):  
Thin Film ◽  
Retention Time ◽  
Blood Circulation ◽  
Crystalline State ◽  
Circulation System ◽  
Particle Sizes ◽  
High Pressure Homogenization ◽  
Rapid Dissolution ◽  
Efficient Route

Prolonging in vivo circulation has proved to be an efficient route for enhancing the therapeutic effect of rapidly metabolized drugs. In this study, we aimed to construct a nanocrystal-loaded micelles delivery system to enhance the blood circulation of docetaxel (DOC). We employed high-pressure homogenization to prepare docetaxel nanocrystals (DOC(Nc)), and then produced docetaxel nanocrystal-loaded micelles (DOC(Nc)@mPEG-PLA) by a thin-film hydration method. The particle sizes of optimized DOC(Nc), docetaxel micelles (DOC@mPEG-PLA), and DOC(Nc)@mPEG-PLA were 168.4, 36.3, and 72.5 nm, respectively. The crystallinity of docetaxel was decreased after transforming it into nanocrystals, and the crystalline state of docetaxel in micelles was amorphous. The constructed DOC(Nc)@mPEG-PLA showed good stability as its particle size showed no significant change in 7 days. Despite their rapid dissolution, docetaxel nanocrystals exhibited higher bioavailability. The micelles prolonged the retention time of docetaxel in the circulation system of rats, and DOC(Nc)@mPEG-PLA exhibited the highest retention time and bioavailability. These results reveal that constructing nanocrystal-loaded micelles may be a promising way to enhance the in vivo circulation and bioavailability of rapidly metabolized drugs such as docetaxel.

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