Total Synthesis of Ecteinascidin 743

2006 ◽  
Vol 128 (1) ◽  
pp. 87-89 ◽  
Author(s):  
Jinchun Chen ◽  
Xiaochuan Chen ◽  
Michèle Bois-Choussy ◽  
Jieping Zhu
Keyword(s):  
Total Synthesis ◽  
Ecteinascidin 743

Stereospecific Formal Total Synthesis of Ecteinascidin 743

ChemInform ◽  
2006 ◽  
Vol 37 (27) ◽  
Author(s):  
Shengping Zheng ◽  
Collin Chan ◽  
Takeshi Furuuchi ◽  
Benjamin J. D. Wright ◽  
Bishan Zhou ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Ecteinascidin 743

Stereospecific Formal Total Synthesis of Ecteinascidin 743

2006 ◽  
Vol 118 (11) ◽  
pp. 1786-1791 ◽  
Author(s):  
Shengping Zheng ◽  
Collin Chan ◽  
Takeshi Furuuchi ◽  
Benjamin J. D. Wright ◽  
Bishan Zhou ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Ecteinascidin 743

ChemInform Abstract: Total Synthesis of Ecteinascidin 743.

ChemInform ◽  
2010 ◽  
Vol 33 (42) ◽  
pp. no-no
Author(s):  
Atsushi Endo ◽  
Arata Yanagisawa ◽  
Masanao Abe ◽  
Shigemitsu Tohma ◽  
Toshiyuki Kan ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Ecteinascidin 743

Enantioselective Total Synthesis of Ecteinascidin 743

1996 ◽  
Vol 118 (38) ◽  
pp. 9202-9203 ◽  
Author(s):  
E. J. Corey ◽  
David Y. Gin ◽  
Robert S. Kania
Keyword(s):  
Total Synthesis ◽  
Enantioselective Total Synthesis ◽  
Ecteinascidin 743

Correction to “Total Synthesis of Ecteinascidin 743”

2014 ◽  
Vol 136 (15) ◽  
pp. 5815-5815 ◽  
Author(s):  
Fumiki Kawagishi ◽  
Tatsuya Toma ◽  
Tomohiko Inui ◽  
Satoshi Yokoshima ◽  
Tohru Fukuyama
Keyword(s):  
Total Synthesis ◽  
Ecteinascidin 743

scholarly journals Total synthesis of the isoquinolinium metabolite ETM-204 of Trabectidin

2021 ◽  
Author(s):  
Christian Lembacher-Fadum ◽  
Simon Gissing ◽  
Georg Pour ◽  
Rolf Breinbauer
Keyword(s):  
Ovarian Cancer ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Total Synthesis ◽  
Ph Dependence ◽  
Spectroscopic Characterization ◽  
Pharmaceutical Drug ◽  
Central Elements ◽  
Degradation Studies ◽  
Ecteinascidin 743

AbstractEcteinascidin-743 (Trabectidin, Trabectedin®, Yondelis®) is a synthetically obtained pharmaceutical drug originally isolated from a marine tunicate. Trabectedin is used for the chemotherapy of soft-tissue sarcoma and ovarian cancer. The isoquinolinium metabolite ETM-204 has been found in biotransformation and degradation studies of Trabectedin. We report the first total synthesis of ETM-204 and its full spectroscopic characterization confirming the postulated structure. Central elements of the 12-step synthesis starting from 2-methyl-6-nitrophenol are a Cu-mediated conversion of an iodoarene to a phenol, a Skattebøl-formylation, and a modified Pomeranz–Fritsch cyclization to assemble the isoquinoline ring. The pH-dependence of its visual absorbance could be clarified. Graphic abstract

ChemInform Abstract: Enantioselective Total Synthesis of Ecteinascidin 743.

ChemInform ◽  
2010 ◽  
Vol 28 (4) ◽  
pp. no-no
Author(s):  
E. J. COREY ◽  
D. Y. GIN ◽  
R. S. KANIA
Keyword(s):  
Total Synthesis ◽  
Enantioselective Total Synthesis ◽  
Ecteinascidin 743

scholarly journals Total Synthesis of Ecteinascidin 743.

ChemInform ◽  
2006 ◽  
Vol 37 (22) ◽  
Author(s):  
Jinchun Chen ◽  
Xiaochuan Chen ◽  
Michele Bois-Choussy ◽  
Jieping Zhu
Keyword(s):  
Total Synthesis ◽  
Ecteinascidin 743
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