Controlled Clustering of Superparamagnetic Nanoparticles Using Block Copolymers: Design of New Contrast Agents for Magnetic Resonance Imaging

2006 ◽  
Vol 128 (5) ◽  
pp. 1755-1761 ◽  
Author(s):  
Jean-François Berret ◽  
Nicolas Schonbeck ◽  
Florence Gazeau ◽  
Delphine El Kharrat ◽  
Olivier Sandre ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Block Copolymers ◽  
Contrast Agents ◽  
Superparamagnetic Nanoparticles ◽  
Resonance Imaging

scholarly journals Development of New Contrast Agents for Imaging Function and Metabolism by Magnetic Resonance Imaging

2017 ◽  
Vol 10 ◽  
pp. 1178623X1772213 ◽  
Author(s):  
Alexandra Carvalho ◽  
M Clara Gonçalves ◽  
M Luísa Corvo ◽  
M Bárbara F Martins
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Magnetic Particles ◽  
Superparamagnetic Iron Oxide ◽  
Medical Application ◽  
Magnetic Resonance Images ◽  
Superparamagnetic Nanoparticles ◽  
Resonance Imaging ◽  
Wide Range

Liposomes are interesting nanosystems with a wide range of medical application. One particular application is their ability to enhance contrast in magnetic resonance images; when properly loaded with magnetic/superparamagnetic nanoparticles, this means to act as contrast agents. The design of liposomes loaded with magnetic particles, magnetoliposomes, presents a large number of possibilities depending on the application from image function to metabolism. More interesting is its double function application as theranostics (diagnostics and therapy). The synthesis, characterization, and possible medical applications of two types of magnetoliposomes are reviewed. Their performance will be compared, in particular, their efficiency as contrast agents for magnetic resonance imaging, measured by their relaxivities r1 and r2 relating to their particular composition. One of the magnetoliposomes had 1,2-diacyl-sn-glycero-3-phosphocholine (soy) as the main phospholipid component, with and without cholesterol, varying its phospholipid to cholesterol molar ratios. The other formulation is a long-circulating liposome composed of 1,2-diacyl-sn-glycero-3-phosphocholine (egg), cholesterol, and 1,2-distearoyl-sn-glycerol-3-phosphoethanolamine- N-[methoxy(polyethylene glycol)-2000]. Both nanosystems were loaded with superparamagnetic iron oxide nanoparticles with different sizes and coatings.

Uptake and bioreactivity of charged chitosan-coated superparamagnetic nanoparticles as promising contrast agents for magnetic resonance imaging

2018 ◽  
Vol 14 (1) ◽  
pp. 131-140 ◽  
Author(s):  
Gabriela Kania ◽  
Magdalena Sternak ◽  
Agnieszka Jasztal ◽  
Stefan Chlopicki ◽  
Agnieszka Błażejczyk ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Superparamagnetic Nanoparticles ◽  
Resonance Imaging

Supramolecular Enhancement of Aminoxyl ORCA Contrast Agents

2019 ◽  
Author(s):  
Hamilton Lee ◽  
Jenica Lumata ◽  
Michael A. Luzuriaga ◽  
Candace Benjamin ◽  
Olivia Brohlin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Side Effects ◽  
Magnetic Resonance ◽  
Tobacco Mosaic Virus ◽  
Contrast Agents ◽  
Single Molecule ◽  
Organic Radical ◽  
Resonance Imaging ◽  
Physiological Conditions

<div><div><div><p>Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further over came the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus.</p></div></div></div>

scholarly journals Magnetic resonance thermometry using a GdIII-based contrast agent

2021 ◽  
Vol 57 (14) ◽  
pp. 1770-1773
Author(s):  
S. A. Amali S. Subasinghe ◽  
Jonathan Romero ◽  
Cassandra L. Ward ◽  
Matthew D. Bailey ◽  
Donna R. Zehner ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Resonance Imaging ◽  
Magnetic Resonance Thermometry

The complexes described here serve as contrast agents for magnetic resonance imaging thermometry.

Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T1 relaxivity and selective cytotoxicity to cancer cells

2021 ◽  
Author(s):  
Anton Popov ◽  
Maxim Artemovich Abakumov ◽  
Irina Savintseva ◽  
Artem Ermakov ◽  
Nelly Popova ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Selective Cytotoxicity ◽  
Magnetic Resonance Imaging Mri

Gd-based complexes are widely used as magnetic resonance imaging (MRI) contrast agents. The safety of previously approved contrast agents is questionable and is being re-assessed. The main causes of concern...

scholarly journals Manganese Ferrite Nanoparticles Encapsulated into Vitamin E/Sphingomyelin Nanoemulsions as Contrast Agents for High‐Sensitive Magnetic Resonance Imaging

2021 ◽  
pp. 2101019
Author(s):  
Sandra Díez‐Villares ◽  
Miguel A. Ramos‐Docampo ◽  
Andrés da Silva‐Candal ◽  
Pablo Hervella ◽  
Abi J. Vázquez‐Ríos ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Vitamin E ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Ferrite Nanoparticles ◽  
Manganese Ferrite ◽  
Resonance Imaging

scholarly journals Polyphosphorhydrazone-Based Radical Dendrimers

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1230
Author(s):  
Vega Lloveras ◽  
José Vidal-Gancedo
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Biomedical Applications ◽  
Organic Radicals ◽  
Resonance Imaging ◽  
Metal Free ◽  
Antioxidant Agents ◽  
New Type ◽  
Paramagnetic Properties

The search for new biomedical applications of dendrimers has promoted the synthesis of new radical-based molecules. Specifically, obtaining radical dendrimers has opened the door to their use in various fields such as magnetic resonance imaging, as anti-tumor or antioxidant agents, or the possibility of developing new types of devices based on the paramagnetic properties of organic radicals. Herein, we present a mini review of radical dendrimers based on polyphosphorhydrazone, a new type of macromolecule with which, thanks to their versatility, new metal-free contrast agents are being obtained, among other possible applications.

Colloidally Stable Monodisperse Fe Nanoparticles as T2 Contrast Agents for High-Field Clinical and Preclinical Magnetic Resonance Imaging

2021 ◽  
Vol 4 (2) ◽  
pp. 1235-1242
Author(s):  
Armita Dash ◽  
Barbara Blasiak ◽  
Boguslaw Tomanek ◽  
Abhinandan Banerjee ◽  
Simon Trudel ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
High Field ◽  
Resonance Imaging ◽  
Fe Nanoparticles ◽  
T2 Contrast Agents
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