A Peptide Motif Recognizing a Polymer Stereoregularity

2005 ◽  
Vol 127 (40) ◽  
pp. 13780-13781 ◽  
Author(s):  
Takeshi Serizawa ◽  
Toshiki Sawada ◽  
Hisao Matsuno ◽  
Teruhiko Matsubara ◽  
Toshinori Sato
Keyword(s):  
Peptide Motif

Upregulation of MUC3 mucin expression from a unique peptide motif of mammary-associated amyloid (MAA) from bovine colostrum

2001 ◽  
Vol 120 (5) ◽  
pp. A673-A674
Author(s):  
D MACK ◽  
M LARSON ◽  
S WEI ◽  
A WEBER ◽  
T MCDONALD
Keyword(s):  
Bovine Colostrum ◽  
Peptide Motif ◽  
Unique Peptide ◽  
Mucin Expression

A collagen peptide motif activates calcium signalling in SaOS-2 cells

1995 ◽  
Vol 23 (3) ◽  
pp. 404S-404S ◽  
Author(s):  
TERRY McCANN ◽  
MURRAY C MEIKLE ◽  
ANDREW J NORTHROP ◽  
WILLIAM T MASON ◽  
FRASER McDONALD
Keyword(s):  
Calcium Signalling ◽  
Peptide Motif ◽  
Collagen Peptide

scholarly journals Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex

2010 ◽  
Vol 107 (52) ◽  
pp. 22399-22406 ◽  
Author(s):  
S. S. Rathore ◽  
E. G. Bend ◽  
H. Yu ◽  
M. Hammarlund ◽  
E. M. Jorgensen ◽  
...  
Keyword(s):  
Membrane Fusion ◽  
Initiation Factor ◽  
Peptide Motif

scholarly journals Design of a heme-binding peptide motif adopting a β-hairpin conformation

2018 ◽  
Vol 293 (24) ◽  
pp. 9412-9422 ◽  
Author(s):  
Deepesh Nagarajan ◽  
Sujeesh Sukumaran ◽  
Geeta Deka ◽  
Kiran Krishnamurthy ◽  
Hanudatta S. Atreya ◽  
...  
Keyword(s):  
Peptide Motif ◽  
Heme Binding ◽  
Binding Peptide ◽  
Hairpin Conformation

scholarly journals Defective Signaling to Fyn by a T Cell Antigen Receptor Lacking the α-Chain Connecting Peptide Motif

2000 ◽  
Vol 276 (5) ◽  
pp. 3574-3580 ◽  
Author(s):  
Cristina Ulivieri ◽  
Annick Peter ◽  
Emanuele Orsini ◽  
Ed Palmer ◽  
Cosima T. Baldari
Keyword(s):  
T Cell ◽  
Antigen Receptor ◽  
Peptide Motif ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Α Chain

scholarly journals The phytotoxic activity of the cerato-platanin BcSpl1 resides in a two-peptide motif on the protein surface

2013 ◽  
Vol 15 (4) ◽  
pp. 342-351 ◽  
Author(s):  
Marcos Frías ◽  
Nélida Brito ◽  
Mario González ◽  
Celedonio González
Keyword(s):  
Peptide Motif ◽  
Protein Surface ◽  
Phytotoxic Activity

scholarly journals A212 CHROMOFUNGIN PROTECTS AGAINST DSS-INDUCED COLITIS BY REGULATING P-53 APOPTITIC PATHWAY

2020 ◽  
Vol 3 (Supplement_1) ◽  
pp. 84-85
Author(s):  
A Diarra ◽  
N Eissa ◽  
J Ghia
Keyword(s):  
B Cell Lymphoma ◽  
Peritoneal Macrophages ◽  
Cell Penetrating Peptide ◽  
Peptide Motif ◽  
Apoptotic Pathway ◽  
Apoptosis Pathway ◽  
Cell Penetrating ◽  
Vehicle Treatment ◽  
A Cell

Abstract Background Development of ulcerative colitis is associated with epithelial apoptosis mediated by p53-apoptotic pathway through the activation B-cell lymphoma 2 (Bcl-2), Bcl-2 associated-X protein (BAX) and Bcl-2 antagonist/killer-1 (BAK1) proteins. Chromofungin (CHR), a chromogranin-A derived peptide expressing a cell penetrating peptide motif, decreased the severity of colitis via the suppression of mucosal and pro-inflammatory macrophages-related p53-dependent apoptosis. Aims We aimed to investigate a) whether the gene profile expression of apoptosis could be extended to other p53-associated genes; b) whether the gene expression of some of the p53-apoptosis marker could be confirmed by protein analysis; and c) whether due to the cell penetrating peptide motif, CHR could enter into peritoneal macrophages. Methods UC-related colitis was induced in C57BL/6 mice (7 weeks) by administering dextran sulfate sodium (DSS) (5%, 5 days). Preventive CHR (2.5 mg/kg/day) or vehicle treatment started 1-day before colitis induction and lasted for 5-days. Profiler™ PCR Array was performed to screen a panel of 84 genes representative of the p53 signal pathway in colitic whole mucosa distal colonic samples treated or not with CHR. Western blot analysis was performed to confirm individual protein changes. Naïve macrophages were plated overnight and nonadherent cells were removed the next day. Cells were incubated with rhodamined CHR (4 ul) for 5, 10, 20, 30 min before washing and fixing them, detection was made via confocal microscopy. Results In colitic conditions, an up regulation of 26 genes associated to the p53-dependent apoptosis pathway were detected including Apaf1, Bax, Bbc3, Bcl2, Cradd, Fadd, Cul9, Pmaip1, Tnfrsf10b. In vivo CHR treatment decreased significantly the colitis and was associated with a significant downregulation of 19 genes including the 9 aforementioned when compared with biopsies from colitic groups. Compared to untreated groups, colitic mice treated with CHR demonstrated a significant decrease of BAX and BAK protein and the apoptotic ER stress inducer marker, X-Binding Protein 1. A large number of peritoneal macrophages displayed rhodamine within the all intracellular compartment. The presence of the peptide inside the cell can be visible as early as 5 min and the signal gradually increases. Conclusions CHR decreases the inflammatory process via the suppression of a large number of p53-related apoptotic proteins. CHR quickly enters the macrophage but the exact mechanism of entrance needs to be further defined. Targeting functional analysis of CHR may lead in the future to novel therapeutics for UC. Funding Agencies CCCNSERC

A Highly Convergent Total Synthetic Route to Glycopeptides Carrying a High-Mannose Core Pentasaccharide DomainN-linked to a Natural Peptide Motif

1997 ◽  
Vol 3 (10) ◽  
pp. 1617-1628 ◽  
Author(s):  
Samuel J. Danishefsky ◽  
Shuanghua Hu ◽  
Pier F. Cirillo ◽  
Matthias Eckhardt ◽  
Peter H. Seeberger
Keyword(s):  
Peptide Motif ◽  
Synthetic Route ◽  
Natural Peptide ◽  
High Mannose
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