Carbon−Nitrogen Bond Formation via the Reaction of Terminal Alkynes with a Dinuclear Side-on Dinitrogen Complex

2004 ◽  
Vol 126 (31) ◽  
pp. 9480-9481 ◽  
Author(s):  
Lara Morello ◽  
Jason B. Love ◽  
Brian O. Patrick ◽  
Michael D. Fryzuk
Keyword(s):  
Bond Formation ◽  
Terminal Alkynes ◽  
Dinitrogen Complex ◽  
Nitrogen Bond

ChemInform Abstract: Carbon-Nitrogen Bond Formation Catalyzed by Metalloporphyrins

ChemInform ◽  
2010 ◽  
Vol 32 (23) ◽  
pp. no-no
Author(s):  
Sergio Cenini ◽  
Emma Gallo ◽  
Andrea Penoni
Keyword(s):  
Bond Formation ◽  
Nitrogen Bond

A Valuable Synthesis of Pyrrolo[1,2-a]quinoxalines, Indolo[1,2-a]quinoxalines and their Aza-Analogues by Palladium-Catalyzed Intramolecular Carbon-Nitrogen Bond Formation

Synthesis ◽  
2005 ◽  
Vol 2005 (17) ◽  
pp. 2881-2886 ◽  
Author(s):  
Egle M. Beccalli ◽  
Giorgio Abbiati ◽  
Gianluigi Broggini ◽  
Giuseppe Paladino ◽  
Elisabetta Rossi
Keyword(s):  
Bond Formation ◽  
Palladium Catalyzed ◽  
Nitrogen Bond

Laccase-catalyzed carbon–nitrogen bond formation: coupling and derivatization of unprotected l-phenylalanine with different para-hydroquinones

Amino Acids ◽  
2008 ◽  
Vol 37 (2) ◽  
pp. 315-321 ◽  
Author(s):  
V. Hahn ◽  
A. Mikolasch ◽  
K. Manda ◽  
D. Gördes ◽  
K. Thurow ◽  
...  
Keyword(s):  
Bond Formation ◽  
Nitrogen Bond

Nucleophilic addition at u 3 -alkyne clusters leading to carbon-carbon bond formation

1982 ◽  
Vol 308 (1501) ◽  
pp. 59-66 ◽  
Keyword(s):  
Bond Formation ◽  
Organic Ligand ◽  
Major Product ◽  
Unsaturated Hydrocarbon ◽  
Terminal Alkynes ◽  
Hydrogen Atoms ◽  
Metal Atoms ◽  
Carbon Carbon Bond ◽  
Anionic Species ◽  
A Minor

Reactions of nucleophiles with triosmium carbonyl clusters, especially those containing unsaturated hydrocarbon ligands, are discussed. Attack may be at CO, the metal atoms, at carbon of the organic ligand, or, where there are acidic metal-bound hydrogen atoms, deprotonation to give anionic clusters may occur. New results on the reactions of LiBHEt3 with p3-alkyne clusters of type Os3(CO)10 (RC2R') are considered in the light of the range of possible sites of attack. Protonation of anionic species that are formed gives hydrogenation products with or without the loss of CO. Os3H2(CO)9(RC2R') is usually a minor product, while C-C coupling leads to Os3H(CO)9(CRCR'COH) (in general the major product) and to Os3H(CO)9- (CRCR'CH). With terminal alkynes RC2H H-atom transfer accompanies C-C coupling to give Os3H(CO)9(RC—C =C H 2) in substantial amounts. The initial site of hydride attack (CO, alkyne or metal) is considered in the context of low-temperature 1H n.m.r. results.

scholarly journals C–C (alkynylation) vs C–O (ether) bond formation under Pd/C–Cu catalysis: synthesis and pharmacological evaluation of 4-alkynylthieno[2,3-d]pyrimidines

2011 ◽  
Vol 7 ◽  
pp. 338-345 ◽  
Author(s):  
Dhilli Rao Gorja ◽  
K Shiva Kumar ◽  
K Mukkanti ◽  
Manojit Pal
Keyword(s):  
Cytotoxic Activity ◽  
Catalytic System ◽  
High Selectivity ◽  
Bond Formation ◽  
Terminal Alkynes ◽  
Ether Bond ◽  
Pharmacological Evaluation

The Pd/C–CuI–PPh3 catalytic system facilitated C–C bond formation between 4-chlorothieno[2,3-d]pyrimidines and terminal alkynes in methanol with high selectivity without generating any significant side products arising from C–O bond formation between the chloro compounds and methanol. A variety of novel 4-alkynylthieno[2,3- d]pyrimidines were prepared via alkynylation of 4-chlorothieno[2,3-d]pyrimidines in good to excellent yields. Some of the compounds synthesized were tested for cytotoxic activity in vitro.

scholarly journals Michael Addition of Imidazole to α, β -Unsaturated Carbonyl/Cyano Compound

2018 ◽  
Vol 5 (1) ◽  
pp. 18-31
Author(s):  
Seetaram Mohapatra ◽  
Nilofar Baral ◽  
Nilima Priyadarsini Mishra ◽  
Pravati Panda ◽  
Sabita Nayak
Keyword(s):  
Organic Chemistry ◽  
Amino Acids ◽  
Anticancer Agents ◽  
Michael Addition ◽  
Addition Reaction ◽  
Bond Formation ◽  
Conjugate Addition ◽  
Michael Addition Reaction ◽  
Cyano Compounds ◽  
Nitrogen Bond

Introduction: Aza-Michael addition is an important reaction for carbon-nitrogen bond formation in synthetic organic chemistry. Expalantion: Conjugate addition of imidazole to α,β-unsaturated carbonyl/cyano compounds provides significant numbers of the biologically and synthetically interesting products, such as β-amino acids and β-lactams, which have attracted great attention for their use as key intermediates of anticancer agents, antibiotics and other drugs. Conclusion: This review addresses most significant method for the synthesis of N-substituted imidazole derivatives following Michael addition reaction of imidazole to α,β-unsaturated carbonyl/cyano compounds using ionic liquid/base/acid/enzyme as catalysts from year 2007-2017.

scholarly journals Correction to Nitrogen–Nitrogen Bond Formation via a Substrate-Bound Anion at a Mononuclear Nickel Platform

2018 ◽  
Vol 37 (6) ◽  
pp. 1086-1086 ◽  
Author(s):  
Mikhail D. Kosobokov ◽  
Aaron Sandleben ◽  
Nicolas Vogt ◽  
Axel Klein ◽  
David A. Vicic
Keyword(s):  
Bond Formation ◽  
Nitrogen Bond

Palladium-catalyzed denitrative Sonogashira-type cross-coupling of nitrobenzenes with terminal alkynes

2020 ◽  
Vol 56 (5) ◽  
pp. 790-793 ◽  
Author(s):  
Boya Feng ◽  
Yudong Yang ◽  
Jingsong You
Keyword(s):  
Bond Formation ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Terminal Alkynes ◽  
Cross Coupling Reaction ◽  
Palladium Catalyzed

Described herein is a palladium-catalyzed cross-coupling reaction between nitroarenes and terminal alkynes, offering a facile method for C(sp2)–C(sp) bond formation.

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