Catalytic Asymmetric Synthesis of α-Amino Phosphonates Using Enantioselective Carbon−Carbon Bond-Forming Reactions

2004 ◽  
Vol 126 (21) ◽  
pp. 6558-6559 ◽  
Author(s):  
Shū Kobayashi ◽  
Hiroshi Kiyohara ◽  
Yoshitaka Nakamura ◽  
Ryosuke Matsubara
Keyword(s):  
Asymmetric Synthesis ◽  
Carbon Bond ◽  
Bond Forming ◽  
Catalytic Asymmetric Synthesis ◽  
Carbon Carbon Bond ◽  
Bond Forming Reactions ◽  
Catalytic Asymmetric ◽  
Amino Phosphonates

ChemInform Abstract: Catalytic Asymmetric Carbon-Carbon Bond Forming Reactions Catalyzed by Tetrahydroisoquinoline (TIQ) N,N′-Dioxide Ligands.

ChemInform ◽  
2013 ◽  
Vol 44 (32) ◽  
pp. no-no
Author(s):  
Zamani E. D. Cele ◽  
Sphelele C. Sosibo ◽  
Pher G. Andersson ◽  
Hendrik G. Kruger ◽  
Glenn E. M. Maguire ◽  
...  
Keyword(s):  
Carbon Bond ◽  
Bond Forming ◽  
Carbon Carbon Bond ◽  
Bond Forming Reactions ◽  
Catalytic Asymmetric ◽  
Asymmetric Carbon

The Stereochemistry of Organometallic Compounds. XXIX. Synthesis of Steroidal 1,4-Diphosphine, 1,3-Diphosphine and 1,6-Diphosphine and Their Evaluation as Ligands in Metal Catalyzed Asymmetric Synthesis

1987 ◽  
Vol 40 (6) ◽  
pp. 1083 ◽  
Author(s):  
RJ Thomson ◽  
WR Jackson ◽  
D Haarburger ◽  
EI Klabunovsky ◽  
VA Pavlov
Keyword(s):  
Asymmetric Synthesis ◽  
Asymmetric Hydrogenation ◽  
Organometallic Compounds ◽  
Carbon Bond ◽  
Bond Forming ◽  
Carbon Carbon Bond ◽  
Bond Forming Reactions ◽  
Hydrogenation Reactions ◽  
Metal Catalyzed ◽  
Asymmetric Carbon

The steroidal 1,4-diphosphines 3α- and 3β-diphenylphosphino-2a-(2'-diphenylphosphinoethyl)-5α-cholestanes and their 5H-benzo[b] phosphindole derivatives have been prepared and shown to be useful ligands in asymmetric hydrogenation reactions. Interestingly the 3α- and 3β-derivatives lead to opposing enantioselection preferences when used in these reactions. A steroidal 1,3-diphosphine, 3α-diphenylphosphino-2α-diphenylphosphinomethyl-5α-cholestane, has been prepared as a mixture containing some of the 3β-epimer. The 3α-1,3-diphosphine led to similar enantioselection in hydrogenation reactions as the 3α-1,4-diphosphine, and a model is proposed to explain the sense of the enantioselectivity in the 1,4- and 1,3-diphosphines. A steroidal 1,6-diphosphine has also been prepared but leads to lower optical yields in the hydrogenation reactions. These ligands have been shown to lead to only poor to moderate optical yields when used in asymmetric carbon-carbon bond forming reactions.

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