Imino Acids and Collagen Triple Helix Stability:  Characterization of Collagen-like Polypeptides Containing Hyp-Hyp-Gly Sequence Repeats

2004 ◽  
Vol 126 (37) ◽  
pp. 11402-11403 ◽  
Author(s):  
Rita Berisio ◽  
Vincenzo Granata ◽  
Luigi Vitagliano ◽  
Adriana Zagari
Keyword(s):  
Triple Helix ◽  
Collagen Triple Helix ◽  
Helix Stability ◽  
Imino Acids

Electrostatic Interactions Involving Lysine Make Major Contributions to Collagen Triple-Helix Stability†

Biochemistry ◽  
2005 ◽  
Vol 44 (5) ◽  
pp. 1414-1422 ◽  
Author(s):  
Anton V. Persikov ◽  
John A. M. Ramshaw ◽  
Alan Kirkpatrick ◽  
Barbara Brodsky
Keyword(s):  
Electrostatic Interactions ◽  
Triple Helix ◽  
Collagen Triple Helix ◽  
Helix Stability

Contributions of cation–π interactions to the collagen triple helix stability

2011 ◽  
Vol 508 (1) ◽  
pp. 46-53 ◽  
Author(s):  
Chia-Ching Chen ◽  
Wei Hsu ◽  
Kuo-Chu Hwang ◽  
Jih Ru Hwu ◽  
Chun-Cheng Lin ◽  
...  
Keyword(s):  
Triple Helix ◽  
Π Interactions ◽  
Collagen Triple Helix ◽  
Helix Stability

Characterization of the Nucleation Step and Folding of a Collagen Triple-Helix Peptide†

Biochemistry ◽  
2002 ◽  
Vol 41 (25) ◽  
pp. 8143-8151 ◽  
Author(s):  
Yujia Xu ◽  
Manjiri Bhate ◽  
Barbara Brodsky
Keyword(s):  
Triple Helix ◽  
Collagen Triple Helix

scholarly journals Decoding Collagen Triple Helix Stability by Means of Hybrid DFT Simulations

2019 ◽  
Vol 123 (34) ◽  
pp. 7354-7364 ◽  
Author(s):  
Michele Cutini ◽  
Massimo Bocus ◽  
Piero Ugliengo
Keyword(s):  
Triple Helix ◽  
Collagen Triple Helix ◽  
Helix Stability ◽  
Dft Simulations

scholarly journals Characterization of three osteogenesis imperfecta collagen α 1(I) glycine to serine mutations demonstrating a position-dependent gradient of phenotypic severity

1992 ◽  
Vol 288 (1) ◽  
pp. 131-135 ◽  
Author(s):  
J F Bateman ◽  
I Moeller ◽  
M Hannagan ◽  
D Chan ◽  
W G Cole
Keyword(s):  
Osteogenesis Imperfecta ◽  
Triple Helix ◽  
Type I Collagen ◽  
Type I ◽  
Disruptive Effect ◽  
Collagen Triple Helix ◽  
C Terminus ◽  
Glycine Substitution ◽  
C And N

Type I collagen alpha 1(I) glycine to serine substitutions, resulting from G-to-A mutations, were defined in three cases of osteogenesis imperfecta (OI). The Gly substitutions displayed a gradient of phenotypic severity according to the location of the mutation in the collagen triple helix. The most C-terminal of these, Gly565 to Ser, led to the lethal perinatal (type II) form of OI, whereas the more N-terminal mutations, Gly415 and Gly352 to Ser, led to severe OI (type III/IV) and moderate OI (type IVB) respectively. These data support the notion that glycine substitutions towards the C-terminus of the alpha 1(I) or alpha 2(I) chains will be more clinically severe than those towards the N-terminus. This results from the more disruptive effect of the mutations at the C-terminus on helix initiation and C- and N-terminal helix directional propagation. This generalization must be modified by considering the nature of the glycine substitution and the surrounding amino acid sequence, since the helix is composed of subdomains of differing stability which will affect the ability of helix re-nucleation and propagation.

Photocontrol of the Collagen Triple Helix: Synthesis and Conformational Characterization of Bis-cysteinyl Collagenous Peptides with an Azobenzene Clamp

2007 ◽  
Vol 13 (10) ◽  
pp. 2966-2973 ◽  
Author(s):  
Ulrike Kusebauch ◽  
Sergio A. Cadamuro ◽  
Hans-Jürgen Musiol ◽  
Luis Moroder ◽  
Christian Renner
Keyword(s):  
Triple Helix ◽  
Collagen Triple Helix

Control of Collagen Triple Helix Stability by Phosphorylation

2017 ◽  
Vol 18 (4) ◽  
pp. 1157-1161 ◽  
Author(s):  
Amanda M. Acevedo-Jake ◽  
Daniel H. Ngo ◽  
Jeffrey D. Hartgerink
Keyword(s):  
Triple Helix ◽  
Collagen Triple Helix ◽  
Helix Stability

Tuning of Collagen Triple-Helix Stability in Recombinant Telechelic Polymers

2012 ◽  
Vol 13 (5) ◽  
pp. 1250-1258 ◽  
Author(s):  
Catarina I. F. Silva ◽  
Paulina J. Skrzeszewska ◽  
Monika D. Golinska ◽  
Marc W. T. Werten ◽  
Gerrit Eggink ◽  
...  
Keyword(s):  
Triple Helix ◽  
Telechelic Polymers ◽  
Collagen Triple Helix ◽  
Helix Stability

scholarly journals Mini-collagens in hydra nematocytes.

1991 ◽  
Vol 115 (4) ◽  
pp. 1159-1169 ◽  
Author(s):  
E M Kurz ◽  
T W Holstein ◽  
B M Petri ◽  
J Engel ◽  
C N David
Keyword(s):  
Amino Acid ◽  
Central Region ◽  
Triple Helix ◽  
Amino Acid Sequences ◽  
Disulfide Linkage ◽  
Amino Terminal ◽  
Collagen Triple Helix ◽  
Polyproline Ii ◽  
Carboxy Terminal

We have isolated and characterized four collagen-related c-DNA clones (N-COL 1, N-COL 2, N-COL 3, N-COL 4) that are highly expressed in developing nematocytes in hydra. All four c-DNAs as well as their corresponding transcripts are small in size (600-1,000 bp). The deduced amino acid sequences show that they contain a central region consisting of 14 to 16 Gly-X-Y triplets. This region is flanked amino-terminal by a stretch of 14-23 proline residues and carboxy-terminal by a stretch of 6-9 prolines. At the NH2- and COOH-termini are repeated patterns of cysteine residues that are highly conserved between the molecules. A model is proposed which consists of a central stable collagen triple helix of 12-14 nm length from which three 9-22 nm long polyproline II type helices emerge at both ends. Disulfide linkage between cysteine-rich segments in these helices could lead to the formation of oligomeric network structures. Electrophoretic characterization of nematocyst extracts allows resolution of small proline-rich polypeptides that correspond in size to the cloned sequences.

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