Kinetics and Mechanism of the General-Acid-Catalyzed Ring-Closure of the Malondialdehyde−DNA Adduct,N2-(3-Oxo-1-propenyl)deoxyguanosine (N2OPdG-), to 3-(2‘-Deoxy-β-d-erythro-pentofuranosyl)pyrimido[1,2-α]purin- 10(3H)-one (M1dG)

2004 ◽  
Vol 126 (34) ◽  
pp. 10571-10581 ◽  
Author(s):  
James N. Riggins ◽  
Derek A. Pratt ◽  
Markus Voehler ◽  
J. Scott Daniels ◽  
Lawrence J. Marnett
Keyword(s):  
Dna Adduct ◽  
Kinetics And Mechanism ◽  
Ring Closure ◽  
General Acid ◽  
Acid Catalyzed

Solvent effects on kinetics and mechanism of acid-catalyzed decomposition of 1,3-bis(4-methylphenyl)triazene I. Reactions in alcohols

1990 ◽  
Vol 55 (1) ◽  
pp. 147-155 ◽  
Author(s):  
Taťjana Nevěčná ◽  
Oldřich Pytela ◽  
Miroslav Ludwig ◽  
Jaromír Kaválek
Keyword(s):  
Trichloroacetic Acid ◽  
Acid Catalysis ◽  
Acid Catalyst ◽  
Kinetics And Mechanism ◽  
Acid Catalysts ◽  
Effect Of Solvents ◽  
Protic Solvents ◽  
General Acid ◽  
Catalytically Active ◽  
Acid Catalyzed

The effect of protic solvents (methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, cyclohexanol) has been studied on the kinetics and mechanism of acid-catalyzed decomposition of 1,3-bis(4-methylphenyl)triazene, using trichloroacetic acid as the acid catalyst. Both the non-dissociated acid and the proton have been found to be catalytically active. The mechanism of splitting of the triazene substrate with the non-dissociated acid involves the general acid catalysis. Comparison of the catalytic rate constants of the two acid catalysts and effect of solvents on these values indicate that the general acid catalysis probably also operates in the reaction of the substrate with proton.

ChemInform Abstract: CYCLOHEXADIENYL CATIONS. 7. KINETICS AND MECHANISM OF THE ACID-CATALYZED DIENOL-BENZENE REARRANGEMENT

1978 ◽  
Vol 9 (23) ◽  
Author(s):  
V. P. VITULLO ◽  
M. J. CASHEN ◽  
J. N. MARX ◽  
L. J. CAUDLE ◽  
J. R. FRITZ
Keyword(s):  
Kinetics And Mechanism ◽  
Acid Catalyzed

The nature of the steric effect in the general-acid-catalyzed hydrolyses of benzaldehyde acetals

1983 ◽  
Vol 48 (23) ◽  
pp. 4175-4179 ◽  
Author(s):  
James L. Jensen ◽  
Anna B. Martinez ◽  
Cheryl L. Shimazu
Keyword(s):  
Steric Effect ◽  
General Acid ◽  
Acid Catalyzed
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