One-Pot Synthesis of Nitrogen Heterocycles Initiated by Regio- and Diastereoselective Carbon−Carbon Bond Formation of Bifunctional Carbonyl Compounds

2004 ◽  
Vol 126 (2) ◽  
pp. 466-467 ◽  
Author(s):  
Ikuya Shibata ◽  
Hirofumi Kato ◽  
Nobuaki Kanazawa ◽  
Makoto Yasuda ◽  
Akio Baba
Keyword(s):  
Carbonyl Compounds ◽  
Bond Formation ◽  
Nitrogen Heterocycles ◽  
One Pot ◽  
Carbon Bond ◽  
One Pot Synthesis ◽  
Carbon Carbon Bond

ChemInform Abstract: One-Pot Synthesis of α-Amino Acids Based on Free Radical-Mediated Carbon-Carbon Bond Formation.

ChemInform ◽  
2010 ◽  
Vol 30 (14) ◽  
pp. no-no
Author(s):  
Hideto Miyabe ◽  
Naoko Yoshioka ◽  
Masafumi Ueda ◽  
Takeaki Naito
Keyword(s):  
Amino Acids ◽  
Free Radical ◽  
Bond Formation ◽  
One Pot ◽  
Carbon Bond ◽  
One Pot Synthesis ◽  
Carbon Carbon Bond

scholarly journals Transition Metal-Catalyzed α-Position Carbon–Carbon Bond Formations of Carbonyl Derivatives

Catalysts ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 861 ◽  
Author(s):  
Ha-Eun Lee ◽  
Dopil Kim ◽  
Ahrom You ◽  
Myung Hwan Park ◽  
Min Kim ◽  
...  
Keyword(s):  
Transition Metal ◽  
Carbonyl Compounds ◽  
Bond Formation ◽  
Chiral Ligand ◽  
Catalytic Systems ◽  
Carbon Bond ◽  
Carbonyl Derivatives ◽  
Carbon Carbon Bond ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

α-Functionalization of carbonyl compounds in organic synthesis has traditionally been accomplished via classical enolate chemistry. As α-functionalized carbonyl moieties are ubiquitous in biologically and pharmaceutically valuable molecules, catalytic α-alkylations have been extensively studied, yielding a plethora of practical and efficient methodologies. Moreover, stereoselective carbon–carbon bond formation at the α-position of achiral carbonyl compounds has been achieved by using various transition metal–chiral ligand complexes. This review describes recent advances—in the last 20 years and especially focusing on the last 10 years—in transition metal-catalyzed α-alkylations of carbonyl compounds, such as aldehydes, ketones, imines, esters, and amides and in efficient carbon–carbon bond formations. Active catalytic species and ligand design are discussed, and mechanistic insights are presented. In addition, recently developed photo-redox catalytic systems for α-alkylations are described as a versatile synthetic tool for the synthesis of chiral carbonyl-bearing molecules.

scholarly journals One-pot oxidative carbon–carbon bond formation of 3-benzylic and 3-allylic indoles with carbon nucleophiles

Tetrahedron ◽  
2008 ◽  
Vol 64 (22) ◽  
pp. 5262-5267 ◽  
Author(s):  
Jun-ichi Matsuo ◽  
Yumi Tanaki ◽  
Hiroyuki Ishibashi
Keyword(s):  
Bond Formation ◽  
One Pot ◽  
Carbon Bond ◽  
Carbon Nucleophiles ◽  
Carbon Carbon Bond
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