Thermodynamics of Binding of 2-Methoxy-3-isopropylpyrazine and 2-Methoxy-3-isobutylpyrazine to the Major Urinary Protein

2004 ◽  
Vol 126 (6) ◽  
pp. 1675-1681 ◽  
Author(s):  
Richard J. Bingham ◽  
John B. C. Findlay ◽  
Shih-Yang Hsieh ◽  
Arnout P. Kalverda ◽  
Alexandra Kjellberg ◽  
...  
Science ◽  
1965 ◽  
Vol 149 (3687) ◽  
pp. 981-982 ◽  
Author(s):  
J. S. Finlayson ◽  
R. Asofsky ◽  
M. Potter ◽  
C. C. Runner

Gene ◽  
1982 ◽  
Vol 18 (3) ◽  
pp. 221-230 ◽  
Author(s):  
A.John Clark ◽  
Patricia M. Clissold ◽  
John O. Bishop

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Guadalupe Gómez-Baena ◽  
Stuart D. Armstrong ◽  
Josiah O. Halstead ◽  
Mark Prescott ◽  
Sarah A. Roberts ◽  
...  

1983 ◽  
Vol 3 (12) ◽  
pp. 2232-2240
Author(s):  
J L Knopf ◽  
J F Gallagher ◽  
W A Held

The hormonal requirements for the regulation of the major urinary protein (MUP) mRNA levels in mouse liver have been examined. Previous experiments have shown that administration of testosterone to female or castrated male mice increases MUP mRNA levels approximately fivefold to normal male levels. We have found that thyroxine and the peptide hormone, growth hormone, each had a pronounced effect on MUP mRNA levels. MUP mRNA was reduced 150-fold in growth-hormone-deficient mutant mice (little). The administration of growth hormone and thyroxine induced MUP mRNA approximately 150-fold, and when administered together, they induced MUP mRNA approximately 1,000-fold. testosterone administration. When administered separately to these mice, growth hormone and thyroxine induced with MUP mRNA approximately 150-fold, and when administered together, they induced MUP mRNA approximately 1,000-fold. Testicular feminized mice, which lack a functional major testosterone receptor protein, can also be induced to male levels by treatment with both growth hormone and thyroxine. In addition, we present evidence which indicates that growth hormone, thyroxine, and testosterone differentially regulate the levels of distinct MUP mRNA species.


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