Self-Assembling Peptide Nanotubes from Enantiomeric Pairs of Cyclic Peptides with AlternatingdandlAmino Acid Residues

2004 ◽  
Vol 126 (11) ◽  
pp. 3372-3373 ◽  
Author(s):  
Katri Rosenthal-Aizman ◽  
Gunnar Svensson ◽  
Anders Undén
Keyword(s):  
Cyclic Peptides ◽  
Peptide Nanotubes ◽  
Self Assembling

scholarly journals New self-assembling peptide nanotubes of large diameter using δ-amino acids

2018 ◽  
Vol 9 (43) ◽  
pp. 8228-8233 ◽  
Author(s):  
Alejandro Lamas ◽  
Arcadio Guerra ◽  
Manuel Amorín ◽  
Juan R. Granja
Keyword(s):  
Amino Acids ◽  
Building Block ◽  
Cyclic Peptides ◽  
Large Diameter ◽  
Peptide Nanotubes ◽  
Self Assembling ◽  
Aminocyclohexanecarboxylic Acid

Here we show that 4-aminocyclohexanecarboxylic acid is a rigid stretcher building block for the preparation of cyclic peptides that self-assemble to form peptide nanotubes with large diameter and hydrophobic pores.

scholarly journals Transmembrane Self-Assembled Cyclic Peptide Nanotubes Based on α‐Residues and Cyclic δ‐Amino Acids: A Computational Study

2021 ◽  
Vol 9 ◽  
Author(s):  
Alexandre Blanco-González ◽  
Martín Calvelo ◽  
Pablo F. Garrido ◽  
Manuel Amorín ◽  
Juan R. Granja ◽  
...  
Keyword(s):  
Amino Acids ◽  
Cyclic Peptides ◽  
Cyclic Peptide ◽  
Computational Study ◽  
Peptide Nanotubes ◽  
Peptide Motifs ◽  
Self Assembling ◽  
Transmembrane Channels ◽  
Dynamics Simulations ◽  
Cyclic Peptide Nanotubes

Self-assembling cyclic peptide nanotubes have been shown to function as synthetic, integral transmembrane channels. The combination of natural and nonnatural aminoacids in the sequence of cyclic peptides enables the control not only of their outer surface but also of the inner cavity behavior and properties, affecting, for instance, their permeability to different molecules including water and ions. Here, a thorough computational study on a new class of self-assembling peptide motifs, in which δ-aminocycloalkanecarboxylic acids are alternated with natural α-amino acids, is presented. The presence of synthetic δ-residues creates hydrophobic regions in these α,δ-SCPNs, which makes them especially attractive for their potential implementation in the design of new drug or diagnostic agent carrier systems. Using molecular dynamics simulations, the behavior of water molecules, different ions (Li+, Na+, K+, Cs+, and Ca2+), and their correspondent counter Cl− anions is extensively investigated in the nanoconfined environment. The structure and dynamics are mutually combined in a diving immersion inside these transmembrane channels to discover a fascinating submarine nanoworld where star-shaped water channels guide the passage of cations and anions therethrough.

scholarly journals Hypothesis: daptomycin permeabilizes membranes by forming self-assembled nanotubes

2020 ◽  
Vol 7 (1) ◽  
pp. 59-71
Author(s):  
Alexander Zhivich ◽  
Keyword(s):  
Experimental Data ◽  
Clinical Practice ◽  
Mechanism Of Action ◽  
Mode Of Action ◽  
Cyclic Peptides ◽  
Bacterial Membrane ◽  
Peptide Nanotubes ◽  
Self Assembling ◽  
Primary Focus ◽  
Lipopeptide Antibiotic

Daptomycin is the only lipopeptide antibiotic that is widely used in clinical practice. It was discovered by Eli Lilly and then studied and commercialized by Cubist Pharmaceuticals in 2003. Although this antibiotic has been used for 17 years, the debate over its mechanism of action is ongoing. In this paper, we discuss the different hypotheses on the mode of action of this antibiotic with a primary focus on the bacterial membrane permeabilization as the main mechanism of action. By comparing the experimental data on the oligomerization of daptomycin in membranes with properties of self-assembling cyclic peptides, we conclude that the structure of daptomycin oligomer should resemble the structures of peptide nanotubes that serve as ion channels in membranes.

Artificial transmembrane ion channels from self-assembling peptide nanotubes

Nature ◽  
1994 ◽  
Vol 369 (6478) ◽  
pp. 301-304 ◽  
Author(s):  
M. Reza Ghadiri ◽  
Juan R. Granja ◽  
Lukas K. Buehler
Keyword(s):  
Ion Channels ◽  
Peptide Nanotubes ◽  
Self Assembling

scholarly journals Nanoscale assemblies and their biomedical applications

2013 ◽  
Vol 10 (80) ◽  
pp. 20120740 ◽  
Author(s):  
Tais A. P. F. Doll ◽  
Senthilkumar Raman ◽  
Raja Dey ◽  
Peter Burkhard
Keyword(s):  
Biomedical Applications ◽  
Vaccine Development ◽  
Building Blocks ◽  
Eukaryotic Cells ◽  
Peptide Nanotubes ◽  
Protein Cages ◽  
Bacterial Microcompartments ◽  
Self Assembling ◽  
Development Section ◽  
Characteristic Features

Nanoscale assemblies are a unique class of materials, which can be synthesized from inorganic, polymeric or biological building blocks. The multitude of applications of this class of materials ranges from solar and electrical to uses in food, cosmetics and medicine. In this review, we initially highlight characteristic features of polymeric nanoscale assemblies as well as those built from biological units (lipids, nucleic acids and proteins). We give special consideration to protein nanoassemblies found in nature such as ferritin protein cages, bacterial microcompartments and vaults found in eukaryotic cells and designed protein nanoassemblies, such as peptide nanofibres and peptide nanotubes. Next, we focus on biomedical applications of these nanoscale assemblies, such as cell targeting, drug delivery, bioimaging and vaccine development. In the vaccine development section, we report in more detail the use of virus-like particles and self-assembling polypeptide nanoparticles as new vaccine delivery platforms.

Self-assembling peptide nanotubes

Nano Today ◽  
2008 ◽  
Vol 3 (3-4) ◽  
pp. 22-30 ◽  
Author(s):  
Shane Scanlon ◽  
Amalia Aggeli
Keyword(s):  
Peptide Nanotubes ◽  
Self Assembling
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