Palladium-Catalyzed [3+2] Intramolecular Cycloaddition of Alk-5-ynylidenecyclopropanes:  A Rapid, Practical Approach to Bicyclo[3.3.0]octenes

2003 ◽  
Vol 125 (31) ◽  
pp. 9282-9283 ◽  
Author(s):  
Alejandro Delgado ◽  
J. Ramón Rodríguez ◽  
Luis Castedo ◽  
José L. Mascareñas
Keyword(s):  
Practical Approach ◽  
Intramolecular Cycloaddition ◽  
Palladium Catalyzed ◽  
Alk 5

Palladium-Catalyzed [3 + 2] Intramolecular Cycloaddition of Alk-5-enylidenecyclopropanes

2006 ◽  
Vol 128 (2) ◽  
pp. 384-385 ◽  
Author(s):  
Moisés Gulías ◽  
Rebeca García ◽  
Alejandro Delgado ◽  
Luis Castedo ◽  
José L. Mascareñas
Keyword(s):  
Intramolecular Cycloaddition ◽  
Palladium Catalyzed ◽  
Alk 5

Mechanistic study on the palladium-catalyzed (3 + 2) intramolecular cycloaddition of alk-5-enylidenecyclopropanes

2012 ◽  
Vol 41 (31) ◽  
pp. 9468 ◽  
Author(s):  
Rebeca García-Fandiño ◽  
Moisés Gulías ◽  
Jose L. Mascareñas ◽  
Diego J. Cárdenas
Keyword(s):  
Mechanistic Study ◽  
Intramolecular Cycloaddition ◽  
Palladium Catalyzed ◽  
Alk 5

scholarly journals Palladium-Catalyzed [3 + 2] Intramolecular Cycloaddition of Alk-5-enylidenecyclopropanes.

ChemInform ◽  
2006 ◽  
Vol 37 (21) ◽  
Author(s):  
Moises Gulias ◽  
Rebeca Garcia ◽  
Alejandro Delgado ◽  
Luis Castedo ◽  
Jose L. Mascarenas
Keyword(s):  
Intramolecular Cycloaddition ◽  
Palladium Catalyzed ◽  
Alk 5

scholarly journals Optimised Conditions for the Palladium-Catalyzed Hydrogenolysis of Benzyl and Naphthylmethyl Ethers: Preventing Saturation of Aromatic Protecting Groups

2020 ◽  
Author(s):  
Conor Crawford ◽  
Stefan Oscarson
Keyword(s):  
Treatment Strategy ◽  
Continuous Flow ◽  
Practical Approach ◽  
Protecting Groups ◽  
Flow Conditions ◽  
Selective Catalyst ◽  
Palladium Catalyzed ◽  
Synthetic Oligosaccharides ◽  
Pre Treatment

<p>Whilst carrying out palladium catalysed hydrogenolysis to deprotect synthetic oligosaccharides, saturation of the benzyl and naphthylmethyl ether groups to their corresponding ether was observed. In order to suppress this unwanted hydrogenation, we report a scalable practical approach using a catalyst pre-treatment strategy, which is effective under batch or continuous flow conditions. This suppressed the unwanted hydrogenation side-products and created a selective catalyst for hydrogenolysis of benzyl and naphthylmethyl ethers. We demonstrate the efficient deprotection of a set of structurally diverse oligosaccharides (5 examples, >73%).</p>

scholarly journals Ruthenium-Catalyzed [3 + 2] Intramolecular Cycloaddition of Alk-5-ynylidenecyclopropanes Promoted by the “First-Generation” Grubbs Carbene Complex.

ChemInform ◽  
2004 ◽  
Vol 35 (51) ◽  
Author(s):  
Fernando Lopez ◽  
Alejandro Delgado ◽  
J. Ramon Rodriguez ◽  
Luis Castedo ◽  
Jose L. Mascarenas
Keyword(s):  
First Generation ◽  
Intramolecular Cycloaddition ◽  
Carbene Complex ◽  
Alk 5

scholarly journals Optimised Conditions for the Palladium-Catalyzed Hydrogenolysis of Benzyl and Naphthylmethyl Ethers: Preventing Saturation of Aromatic Protecting Groups

2020 ◽  
Author(s):  
Conor Crawford ◽  
Stefan Oscarson
Keyword(s):  
Treatment Strategy ◽  
Continuous Flow ◽  
Practical Approach ◽  
Protecting Groups ◽  
Flow Conditions ◽  
Selective Catalyst ◽  
Palladium Catalyzed ◽  
Synthetic Oligosaccharides ◽  
Pre Treatment

<p>Whilst carrying out palladium catalysed hydrogenolysis to deprotect synthetic oligosaccharides, saturation of the benzyl and naphthylmethyl ether groups to their corresponding ether was observed. In order to suppress this unwanted hydrogenation, we report a scalable practical approach using a catalyst pre-treatment strategy, which is effective under batch or continuous flow conditions. This suppressed the unwanted hydrogenation side-products and created a selective catalyst for hydrogenolysis of benzyl and naphthylmethyl ethers. We demonstrate the efficient deprotection of a set of structurally diverse oligosaccharides (5 examples, >73%).</p>

Palladium-Catalyzed [4 + 3] Intramolecular Cycloaddition of Alkylidenecyclopropanes and Dienes

2007 ◽  
Vol 129 (36) ◽  
pp. 11026-11027 ◽  
Author(s):  
Moisés Gulías ◽  
Juan Durán ◽  
Fernando López ◽  
Luis Castedo ◽  
Jose L. Mascareñas
Keyword(s):  
Intramolecular Cycloaddition ◽  
Palladium Catalyzed

Palladium-catalyzed three-component carbonylative synthesis of 2-(trifluoromethyl)quinazolin-4(3H)-ones from trifluoroacetimidoyl chlorides and amines

2020 ◽  
Vol 7 (17) ◽  
pp. 2499-2504 ◽  
Author(s):  
Zhengkai Chen ◽  
Le-Cheng Wang ◽  
Jiajun Zhang ◽  
Xiao-Feng Wu
Keyword(s):  
Practical Approach ◽  
Palladium Catalyzed

An efficient and practical approach for the synthesis of 2-(trifluoromethyl)quinazolin-4(3H)-ones through palladium-catalyzed three-component carbonylative reaction has been developed.

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