Solution NMR Characterization of the Electronic Structure and Magnetic Properties of High-Spin Ferrous Heme in Deoxy Myoglobin fromAplysialimacina

2003 ◽  
Vol 125 (28) ◽  
pp. 8494-8504 ◽  
Author(s):  
Dejian Ma ◽  
Raffaella Musto ◽  
Kevin M. Smith ◽  
Gerd N. La Mar
Keyword(s):  
Magnetic Properties ◽  
Electronic Structure ◽  
High Spin ◽  
Solution Nmr ◽  
Nmr Characterization ◽  
Ferrous Heme

scholarly journals Evidence that the TRPV1 S1-S4 Membrane Domain Contributes to Thermosensing

2019 ◽  
Author(s):  
Minjoo Kim ◽  
Nicholas J. Sisco ◽  
Jacob K. Hilton ◽  
Camila M. Montano ◽  
Manuel A. Castro ◽  
...  
Keyword(s):  
Conformational Changes ◽  
Solution Nmr ◽  
Membrane Domain ◽  
Temperature Dependent ◽  
Nmr Characterization ◽  
Significant Interest ◽  
Pore Domain ◽  
Coupling Mechanisms

AbstractSensing and responding to temperature is crucial in biology. The TRPV1 ion channel is a well-studied heat-sensing receptor that is also activated by vanilloid compounds including capsaicin. Despite significant interest, the molecular underpinnings of thermosensing have remained elusive. The TRPV1 S1-S4 membrane domain couples chemical ligand binding to the pore domain during channel gating. However, the role of the S1-S4 domain in thermosensing is unclear. Evaluation of the isolated human TRPV1 S1-S4 domain by solution NMR, Far-UV CD, and intrinsic fluorescence shows that this domain undergoes a non-denaturing temperature-dependent transition with a high thermosensitivity. Further NMR characterization of the temperature-dependent conformational changes suggests the contribution of the S1-S4 domain to thermosensing shares features with known coupling mechanisms between this domain with ligand and pH activation. Taken together, this study shows that the TRPV1 S1-S4 domain contributes to TRPV1 temperature-dependent activation.

Electronic structure and magnetic properties of high-spin octahedral Co(II) complexes: Co(II)(acac)2(H2O)2

1999 ◽  
Vol 111 (22) ◽  
pp. 10148-10158 ◽  
Author(s):  
Lawrence L. Lohr ◽  
Jeremy C. Miller ◽  
Robert R. Sharp
Keyword(s):  
Magnetic Properties ◽  
Electronic Structure ◽  
High Spin

Comprehensive Solid-State NMR Characterization of Electronic Structure in Ditechnetium Heptoxide

2010 ◽  
Vol 132 (38) ◽  
pp. 13138-13140 ◽  
Author(s):  
Herman Cho ◽  
Wibe A. de Jong ◽  
Alfred P. Sattelberger ◽  
Frédéric Poineau ◽  
Kenneth R. Czerwinski
Keyword(s):  
Electronic Structure ◽  
Solid State ◽  
Solid State Nmr ◽  
Nmr Characterization

Approaches to the Solution NMR Characterization of Active Sites for 65 kDa Tetrameric Hemoglobins in the Paramagnetic Cyanomet State

1997 ◽  
Vol 119 (51) ◽  
pp. 12643-12654 ◽  
Author(s):  
Urszula Kolczak ◽  
Chang Han ◽  
L. A. Sylvia ◽  
Gerd N. La Mar
Keyword(s):  
Active Sites ◽  
Solution Nmr ◽  
Nmr Characterization

Solution1H NMR Study of the Electronic Structure and Magnetic Properties of High-Spin Ferrous or Deoxy Myoglobins⊥

1998 ◽  
Vol 120 (9) ◽  
pp. 2113-2123 ◽  
Author(s):  
Catherine M. Bougault ◽  
Yi Dou ◽  
Masao Ikeda-Saito ◽  
Kevin C. Langry ◽  
Kevin M. Smith ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Electronic Structure ◽  
High Spin ◽  
Nmr Study

scholarly journals Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions

2015 ◽  
Vol 472 (1) ◽  
pp. 121-133 ◽  
Author(s):  
Prem Raj B. Joseph ◽  
Philip D. Mosier ◽  
Umesh R. Desai ◽  
Krishna Rajarathnam
Keyword(s):  
Structural Plasticity ◽  
Neutrophil Function ◽  
Solution Nmr ◽  
Binding Interactions ◽  
High Affinity ◽  
Nmr Characterization ◽  
Differential Binding

Structural plasticity plays a major role in determining differential binding of CXCL8 monomer and dimer to glycosaminoglycans (GAGs) and that dimer is the high-affinity GAG ligand. We propose that these properties play important roles in orchestrating in vivo chemokine-mediated neutrophil function.

Magnetic properties and electronic structure of high spin iron(III) porphyrins

1983 ◽  
Vol 78 (3) ◽  
pp. 1453-1458 ◽  
Author(s):  
Roshun Birdy ◽  
D. V. Behere ◽  
S. Mitra
Keyword(s):  
Magnetic Properties ◽  
Electronic Structure ◽  
High Spin ◽  
High Spin Iron

Solution NMR Study of the Electronic Structure and Magnetic Properties of Cluster Ligation Mutants of the Four-Iron Ferredoxin from the Hyperthermophilic ArchaeonPyrococcus furiosus

1997 ◽  
Vol 119 (40) ◽  
pp. 9341-9350 ◽  
Author(s):  
Luigi Calzolai ◽  
Carol M. Gorst ◽  
Kara L. Bren ◽  
Zhi-Hao Zhou ◽  
Michael W. W. Adams ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Electronic Structure ◽  
Solution Nmr ◽  
Nmr Study
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