Diastereoselective Addition of Chlorotitanium Enolate ofN-Acyl Thiazolidinethione toO-Methyl Oximes:  A Novel, Stereoselective Synthesis of α,β-Disubstituted β-Amino Carbonyl Compounds via Chiral Auxiliary Mediated Azetine Formation

2003 ◽  
Vol 125 (13) ◽  
pp. 3690-3691 ◽  
Author(s):  
Narendra B. Ambhaikar ◽  
James P. Snyder ◽  
Dennis C. Liotta
Keyword(s):  
Carbonyl Compounds ◽  
Stereoselective Synthesis ◽  
Chiral Auxiliary ◽  
Diastereoselective Addition

Diastereoselective Synthesis of Morpholine Derivatives from Grignard Reagents and N-Sulfinyl Imines

Synlett ◽  
2021 ◽  
Author(s):  
Eric P. A. Talbot ◽  
Joseph M. Bateman ◽  
Diana Chan ◽  
Mustafa Moroglu ◽  
Benjamin Rahemtulla
Keyword(s):  
Grignard Reagent ◽  
Stereoselective Synthesis ◽  
Grignard Reagents ◽  
Diastereoselective Synthesis ◽  
Step Process ◽  
Diastereoselective Addition ◽  
Morpholine Derivatives

The stereoselective synthesis of C3-substituted morpholine derivatives has been achieved through a two-step process involving diastereoselective addition of a Grignard reagent to a sulfinyl imine, followed by cyclization.

The Sulfinyl Group as a Remote Chiral Auxiliary in Stereoselective Conjugate Additions of Alkyl Groups to α-Methylidene Carbonyl Compounds Initiated by Et3B/O2

2013 ◽  
Vol 2013 (9) ◽  
pp. 1796-1804 ◽  
Author(s):  
José Antonio Fernández-Salas ◽  
M. Carmen Maestro ◽  
M. Mercedes Rodríguez-Fernández ◽  
José L. García Ruano
Keyword(s):  
Carbonyl Compounds ◽  
Chiral Auxiliary ◽  
Conjugate Additions ◽  
Alkyl Groups ◽  
Sulfinyl Group
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