Base Sequence Effects in Radical Cation Migration in Duplex DNA:  Support for the Polaron-Like Hopping Model

2003 ◽  
Vol 125 (20) ◽  
pp. 6098-6102 ◽  
Author(s):  
Chu-Sheng Liu ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Base Sequence ◽  
Duplex Dna ◽  
Cation Migration ◽  
Sequence Effects ◽  
Hopping Model

Effect of positively charged backbone groups on radical cation migration and reaction in duplex DNA

2011 ◽  
Vol 89 (3) ◽  
pp. 326-330 ◽  
Author(s):  
Sriram Kanvah ◽  
Gary B. Schuster
Keyword(s):  
Radical Cation ◽  
Dna Analysis ◽  
Duplex Dna ◽  
Charge Migration ◽  
Electron Hole ◽  
Dna Oligomers ◽  
Phosphodiester Backbone ◽  
Cation Migration ◽  
Covalently Linked ◽  
Positively Charged

A series of DNA oligomers were prepared that contain guanidinium linkages (positively charged) positioned selectively in place of and among the normal negatively charged phosphodiester backbone groups of duplex DNA. One-electron oxidation of these DNA oligomers by UV irradiation of a covalently linked anthraquinone group generates a radical cation (electron “hole”) that migrates by hopping through the DNA and is trapped at reactive sites, GG steps, to form mutated bases that are detected by strand cleavage after subsequent piperidine treatment of the irradiated DNA. Analysis of the strand cleavage pattern reveals that guanidinium substitution in these oligomers does not measurably affect the charge migration rate but it does inhibit reaction at nearby guanines.

Intrinsic electrostatic properties and base sequence effects in the structure of oligonucleotides

1982 ◽  
Vol 15 (4) ◽  
pp. 343-351 ◽  
Author(s):  
Richard Lavery ◽  
Bernard Pullman ◽  
Krystyna Zakrzewska
Keyword(s):  
Base Sequence ◽  
Electrostatic Properties ◽  
Sequence Effects

Theoretical prediction of base sequence effects in DNA

1989 ◽  
Vol 207 (2) ◽  
pp. 433-444 ◽  
Author(s):  
B. Hartmann ◽  
B. Malfoy ◽  
R. Lavery
Keyword(s):  
Theoretical Prediction ◽  
Base Sequence ◽  
Sequence Effects

Base Sequence Effects in Bending Induced by Bulky Carcinogen−DNA Adducts:  Experimental and Computational Analysis†

Biochemistry ◽  
2001 ◽  
Vol 40 (35) ◽  
pp. 10458-10472 ◽  
Author(s):  
Qian Ruan ◽  
Ping Zhuang ◽  
Sheng Li ◽  
Rebecca Perlow ◽  
A. R. Srinivasan ◽  
...  
Keyword(s):  
Dna Adducts ◽  
Computational Analysis ◽  
Base Sequence ◽  
Sequence Effects

Base Sequence Effects on Transport in DNA

2006 ◽  
Vol 110 (11) ◽  
pp. 5801-5806 ◽  
Author(s):  
Esther M. Conwell ◽  
Steven M. Bloch
Keyword(s):  
Base Sequence ◽  
Sequence Effects
Sign in / Sign up

Export Citation Format

Share Document