Synthesis and Biological Evaluation ofRhizobiumsin-1 Lipid A Derivatives

2003 ◽  
Vol 125 (20) ◽  
pp. 6103-6112 ◽  
Author(s):  
Alexei V. Demchenko ◽  
Margreet A. Wolfert ◽  
Balaji Santhanam ◽  
James N. Moore ◽  
Geert-Jan Boons
Keyword(s):  
Lipid A ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of novel lipid A antagonists

2006 ◽  
Vol 14 (1) ◽  
pp. 190-199 ◽  
Author(s):  
Francesco Peri ◽  
Chiara Marinzi ◽  
Marek Barath ◽  
Francesca Granucci ◽  
Matteo Urbano ◽  
...  
Keyword(s):  
Lipid A ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Synthesis and Biological Evaluation of a Lipid A Derivative That Contains an Aminogluconate Moiety

2004 ◽  
Vol 10 (19) ◽  
pp. 4798-4807 ◽  
Author(s):  
Balaji Santhanam ◽  
Margreet A. Wolfert ◽  
James N. Moore ◽  
Geert-Jan Boons
Keyword(s):  
Lipid A ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

2018 ◽  
Author(s):  
Jonathan J. Mills ◽  
Kaylib R. Robinson ◽  
Troy E. Zehnder ◽  
Joshua G. Pierce
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Mechanism Of Action ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Lead Compounds ◽  
Follow Up Studies ◽  
Initial Resistance ◽  
Synthesis And Biological Evaluation

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

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