Structure Activity Relationship by NMR and by Computer:  A Comparative Study

2002 ◽  
Vol 124 (37) ◽  
pp. 11073-11084 ◽  
Author(s):  
Finton Sirockin ◽  
Christian Sich ◽  
Sabina Improta ◽  
Michael Schaefer ◽  
Vladimir Saudek ◽  
...  
Keyword(s):  
Comparative Study ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity

Comparative efficacy of flubendazole and mebendazole on encysted larvae of Trichinella spiralis (USA strain) in the diaphragm of mice and rats

1988 ◽  
Vol 62 (1) ◽  
pp. 35-39 ◽  
Author(s):  
Jun Maki ◽  
Toshio Yanagisawa
Keyword(s):  
Comparative Study ◽  
Post Infection ◽  
Trichinella Spiralis ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Comparative Efficacy ◽  
Experimental Conditions ◽  
Structure Activity

ABSTRACTComparative efficacy of mebendazole and flubendazole, a p−fluor analogue of mebendazole against the encysted larvae of Trichinella spiralis (USA strain) in the diaphragm of mice and rats were studied in order to provide a better understanding of the structure-activity relationship within the benzimidazole series. Drugs given 10–100 mg/kg/day for 3 consecutive days (35–37 days post-infection) or at 300 mg/kg, 35 days post infection were significantly effective in decreasing early encysted larvae in mice. No significant differences in effectiveness against the early encysted larvae could be observed between the drugs under the present experimental conditions. Mebendazole was found to be more effective that flubendazole in decreasing old encysted larvae in mice treated 70–72 days post-infection based on a comparative study of their ED50 values. When rats were given the drugs at the dose of 10 mg/kg/day for 3 consecutive days, mebendazole was significantly effective against both early and old encysted larvae while flubendazole was not.

Sign in / Sign up

Export Citation Format

Share Document