Total Synthesis of (+)-Aspidospermidine:  A New Strategy for the Enantiospecific Synthesis of Aspidosperma Alkaloids

2002 ◽  
Vol 124 (45) ◽  
pp. 13398-13399 ◽  
Author(s):  
Joseph P. Marino ◽  
Maria B. Rubio ◽  
Ganfeng Cao ◽  
Alfonso de Dios
Keyword(s):  
Total Synthesis ◽  
New Strategy ◽  
Enantiospecific Synthesis

scholarly journals Expedient Access to Enantiopure Cyclopentanic Natural Products: Total Synthesis of (-)-Cyclonerodiol

2015 ◽  
Vol 10 (1) ◽  
pp. 1934578X1501000
Author(s):  
Carmen Pérez Morales ◽  
M. Mar Herrador ◽  
José F. Quílez del Moral ◽  
Alejandro F. Barrero
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Radical Cyclization ◽  
Formal Synthesis ◽  
Common Precursor ◽  
Enantiospecific Synthesis ◽  
Optically Pure

Following the principles of collective total synthesis, a number of natural products sharing an optically pure, multifunctional, cyclopentanic core were synthesized from a common precursor: plinol A (1). This intermediate was efficiently obtained in only four steps from (-)-linalool (2) using as the key step a Ti(III)-mediated diastereoselective radical cyclization. The feasibility of this approach was confirmed with the expedient enantiospecific synthesis of cyclonerodiol (3), and the formal synthesis of chocol G (4) and piperitone (5).

A new strategy for isoflavone C-glycoside synthesis: The total synthesis of puerarin

2018 ◽  
Vol 37 (9) ◽  
pp. 461-470
Author(s):  
Yunpeng Zou ◽  
Tao Peng ◽  
Gang Wang ◽  
Xiaoxue Wen ◽  
Shuchen Liu ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Glycoside Synthesis ◽  
New Strategy
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