Callipeltoside A: Total Synthesis, Assignment of the Absolute and Relative Configuration, and Evaluation of Synthetic Analogues

2002 ◽  
Vol 124 (35) ◽  
pp. 10396-10415 ◽  
Author(s):  
Barry M. Trost ◽  
Janet L. Gunzner ◽  
Olivier Dirat ◽  
Young H. Rhee
Keyword(s):  
Total Synthesis ◽  
Synthetic Analogues ◽  
Relative Configuration ◽  
Callipeltoside A ◽  
The Absolute

ChemInform Abstract: Callipeltoside A: Assignment of Absolute and Relative Configuration by Total Synthesis.

ChemInform ◽  
2010 ◽  
Vol 33 (30) ◽  
pp. no-no
Author(s):  
Barry M. Trost ◽  
Olivier Dirat ◽  
Janet L. Gunzner
Keyword(s):  
Total Synthesis ◽  
Relative Configuration ◽  
Callipeltoside A

Asymmetric Total Synthesis and Determination of the Absolute Configuration of (+)-Srilankenyne via Sequence-Sensitive Halogenations Guided by Conformational Analysis

2021 ◽  
Vol 23 (4) ◽  
pp. 1321-1326
Author(s):  
Hongjun Jang ◽  
Soo Yeon Kwak ◽  
Dongjoo Lee ◽  
Juan V. Alegre-Requena ◽  
Hyoungsu Kim ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Conformational Analysis ◽  
Absolute Configuration ◽  
Asymmetric Total Synthesis ◽  
The Absolute

Total synthesis and absolute structure of N55, a positive modulator of GLP-1 signaling

2020 ◽  
Vol 18 (43) ◽  
pp. 8899-8907
Author(s):  
Nai-Pin Lin ◽  
Rong-Jie Chein
Keyword(s):  
Total Synthesis ◽  
Positive Modulator ◽  
Glucagon Like Peptide ◽  
The Absolute ◽  
Glucagon Like Peptide 1 ◽  
Absolute Structure

The absolute structure of N55, a positive modulator of Glucagon-like peptide-1 (GLP-1) signaling, was determined by a 7-step total synthesis with 29% overall yield.

(+)-Occidentalol: Absolute Stereostructure and Total Synthesis

1972 ◽  
Vol 50 (3) ◽  
pp. 340-345 ◽  
Author(s):  
Young Amano ◽  
Clayton H. Heathcock
Keyword(s):  
Total Synthesis ◽  
Hydroxy Ketone ◽  
Stage Conversion ◽  
The Absolute

Hydroxy ketone 7 has been prepared from both (+)-dihydrocarvone (3) and (+)-occidentalol (2), thus establishing the absolute stereostructure of the latter. The three-stage conversion of compound 7 into (+)-occidentalol constitutes a total synthesis of the sesquiterpene.

Total synthesis and determination of the absolute configuration of (−)-longilene peroxide

2001 ◽  
Vol 42 (36) ◽  
pp. 6307-6309 ◽  
Author(s):  
Yoshiki Morimoto ◽  
Toshiyuki Iwai ◽  
Takamasa Kinoshita
Keyword(s):  
Total Synthesis ◽  
Absolute Configuration ◽  
The Absolute

(-)-Strempeliopine, stereoselective total synthesis and the determination of absolute configuration

1986 ◽  
Vol 51 (8) ◽  
pp. 1731-1742 ◽  
Author(s):  
Josef Hájíček ◽  
Jan Trojánek
Keyword(s):  
Circular Dichroism ◽  
Total Synthesis ◽  
Absolute Configuration ◽  
Determination Of Absolute Configuration ◽  
Natural Base ◽  
The Absolute ◽  
Circular Dichroïsm

A synthesis of (±)-strempeliopine (II) is described, the key step of which is the stereoselective reductive rearrangement of 18-methylene-1,2-dehydroaspidospermidine (XI). The absolute configuration of the natural (-)-base II was determined as (2S, 7R, 20R, 21R) on the basis of its synthesis from (+)-18-methylenevincadifformine (XVII) the configuration of which was derived from a comparison of circular dichroism properties of bases with a β-anilinoacrylate chromophore. The biogenesis of the alkaloids of the schizozygane type is discussed.

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