Purification of the Pressor Principle of the Posterior Lobe of the Pituitary Gland by Electrophoresis

1941 ◽  
Vol 63 (2) ◽  
pp. 503-506 ◽  
Author(s):  
George W. Irving ◽  
Helen M. Dyer ◽  
Vincent du Vigneaud
Keyword(s):  
Pituitary Gland ◽  
Posterior Lobe

scholarly journals The oxytocic hormone of the posterior lobe of the pituitary gland

1935 ◽  
Vol 29 (2) ◽  
pp. 378-390.2 ◽  
Author(s):  
John Masson Gulland ◽  
Sydney Stewart Randall
Keyword(s):  
Pituitary Gland ◽  
Posterior Lobe

On the content of prolan in the pituitary gland

1934 ◽  
Vol 30 (6) ◽  
pp. 634-634
Author(s):  
P. Badul
Keyword(s):  
Pituitary Gland ◽  
Histological Examination ◽  
Anterior Lobe ◽  
Posterior Lobe ◽  
Posterior Pituitary ◽  
Posterior Pituitary Lobe

The posterior lobe of the pituitary gland in a bull is free of prolan, while in a human it contains prolan. Only here it can be found in that part of the posterior pituitary lobe adjacent to the anterior lobe. In the bull, too, this part of the pituitary gland is completely free of prolan content. Histological examination shows that in humans, this part of the posterior lobe is crossed by bands of cells from the anterior lobe, which consist exclusively of basophilic cells.

scholarly journals Immunocytochemical demonstration of tissue-type plasminogen activator in endocrine cells of the rat pituitary gland.

1985 ◽  
Vol 101 (1) ◽  
pp. 305-311 ◽  
Author(s):  
P Kristensen ◽  
L S Nielsen ◽  
J Grøndahl-Hansen ◽  
P B Andresen ◽  
L I Larsson ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pituitary Gland ◽  
Endocrine Cells ◽  
Large Population ◽  
Cell Types ◽  
Anterior Lobe ◽  
Tissue Type ◽  
Intermediate Lobe ◽  
Posterior Lobe ◽  
Rat Pituitary

We immunocytochemically stained rat pituitary glands using antibodies against plasminogen activators of the tissue type (t-PA) and the urokinase type (u-PA). A large population of endocrine cells in the anterior lobe of the gland displayed intense cytoplasmic immunoreactivity with anti-t-PA. In some areas of the intermediate lobe we found a weak staining, and we observed weakly staining granular structures in the posterior lobe. Controls included absorption of the antibodies with highly purified t-PA. In addition, SDS PAGE followed by immunoblotting of pituitary gland extracts revealed only one band with an electrophoretic mobility similar to that of t-PA when stained with anti-t-PA IgG. No u-PA immunoreactivity was detected in the rat pituitary gland. Sequential staining experiments using antibodies against growth hormone and t-PA demonstrated that the t-PA-immunoreactive cells constitute a large subpopulation of the growth hormone-containing cells. These findings represent the first direct evidence for the presence of t-PA in cell types other than endothelial cells in the intact normal organism. In this article we discuss the implications of the results for a possible role of t-PA in the posttranslational processing of prohormones.

DISTRIBUTION OF ADRENOCORTICOTROPHIC HORMONE IN THE PITUITARY GLAND

1957 ◽  
Vol 35 (1) ◽  
pp. 471-480
Author(s):  
G. J. Rochefort ◽  
M. Saffran
Keyword(s):  
Pituitary Gland ◽  
Relative Proportion ◽  
Posterior Lobe ◽  
Adrenocorticotrophic Hormone ◽  
Pituitary Glands

The highly vascular, anteromedial zone of hog and beef pituitary glands, which is rich in basophilic cells, contains a concentration of ACTH from 4 to 13 times that found in the rest of the adenohypophysis. The concentration of ACTH can be correlated (r = 0.96) with the relative proportion of basophilic cells, supporting the view that the pituitary basophiles are the source of ACTH. The distribution of both basophiles and ACTH in the rat adenohypophysis is more uniform than in hog or beef glands. The posterior lobe of all species examined (rat, hog, beef, and man) contains small, but significant, amounts of ACTH.

scholarly journals The oxytocic principle of the posterior lobe of the pituitary gland. I

1932 ◽  
Vol 26 (2) ◽  
pp. 337-348 ◽  
Author(s):  
John Masson Gulland ◽  
William Henry Newton
Keyword(s):  
Pituitary Gland ◽  
Posterior Lobe

scholarly journals SAT-244 Inflammatory Rathke Cleft Cyst Caused Hypothalamic Panhypopituitarism

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Tangiku Mariko ◽  
Tatsuo Ishizuka ◽  
Kei Fujioka ◽  
Saori Inui ◽  
Hideki Tani ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
High Intensity ◽  
Rare Case ◽  
Hormone Replacement ◽  
Ct Scanning ◽  
Serum Cortisol ◽  
Pituitary Hormones ◽  
Posterior Lobe ◽  
Lh Rh ◽  
T2 Weighted Images

Abstract Background: Hypothalamic panhypopituitarism was a rare disease which was caused by brain tumors such as Rathke cyst, germinoma, malignant lymphoma and craniopharyngioma, and vascular accidents such as thrombosis and hemorrhage. We have found a rare case of hypothalamic panhypopituitarism occurred by the inflammation of Rathke cyst. Case presentation: A 77-year-old woman was admitted to our hospital because of severe headache, nausea, vomiting and fever. Hyponatremia (Na 131 meq/L) and increased CRP level (0.20 mg/dl) and no finding of gastroenterological examination and abdominal CT scanning were observed. Endocrinological examination revealed low levels of anterior pituitary hormones such as GH, LH, FSH and ACTH and increased PRL levels and low level of serum cortisol. Simultaneous CRH, TRH and LH-RH stimulations tests indicated low responses of TSH, LH, FSH and PRL and hyperesponse of ACTH (from 2.4 to 251 pg/ml). Radiological examination by enhanced MRI revealed high intensity of T2-weighted images and low and partial high intensities of T1-weighted images in swelling of pituitary gland and vanishment of high intensity of posterior lobe in T2-weighted images suggesting that the inflammatory wall of Rathke cyst. We searched previous data of ACTH and cortisol levels which showed normal level of ACTH (55.2 pg/ml) and cortisol 18.8 μ;g/dl) when headache and nausea arouse on 50 days before. Based on above results patient was diagnosed as hypothalamic hypopituitarism due to inflammatory Rathke cyst. Therefore, patient was treated with hormone replacement therapy by 20 mg of hydrocortisone. After these treatment, polyuria, urinary low osmotic pressure and hypernatremia appeared due to partial diabetes insipidus caused by the impairment of posterior lobe in pituitary gland, and diagnosed by the examination of vasopressin test. This patient was also treated by the oral desmopressin acetate hydrate (60 μ;g/day), and has been well-tolerated in the outpatient clinic. Conclusion: These results suggested that inflammatory Rathke cyst with inflammatory changes in hypothlamo-pituitary system raised a rare case of hypothalamic panhypopituitarism.Reference: Nishioka H. et al.: Clin Endocrinology (Oxf) 2006:64:184–188

DISTRIBUTION OF ADRENOCORTICOTROPHIC HORMONE IN THE PITUITARY GLAND

1957 ◽  
Vol 35 (7) ◽  
pp. 471-480 ◽  
Author(s):  
G. J. Rochefort ◽  
M. Saffran
Keyword(s):  
Pituitary Gland ◽  
Relative Proportion ◽  
Posterior Lobe ◽  
Adrenocorticotrophic Hormone ◽  
Pituitary Glands

The highly vascular, anteromedial zone of hog and beef pituitary glands, which is rich in basophilic cells, contains a concentration of ACTH from 4 to 13 times that found in the rest of the adenohypophysis. The concentration of ACTH can be correlated (r = 0.96) with the relative proportion of basophilic cells, supporting the view that the pituitary basophiles are the source of ACTH. The distribution of both basophiles and ACTH in the rat adenohypophysis is more uniform than in hog or beef glands. The posterior lobe of all species examined (rat, hog, beef, and man) contains small, but significant, amounts of ACTH.

To the doctrine of pituitary hormones

1926 ◽  
Vol 22 (5-6) ◽  
pp. 731
Author(s):  
V. S.
Keyword(s):  
Blood Pressure ◽  
Pituitary Gland ◽  
Pituitary Hormones ◽  
Posterior Lobe ◽  
Pituitary Extract ◽  
Human Pituitary ◽  
Human Pituitary Gland ◽  
Uterine Muscle

W. Lampe (Wiener kl. Woch., 1926, No. 1) prepared from the posterior lobe of the human pituitary gland, by extraction with acetone, a dry preparation, which in its effect on blood pressure, diuresis and uterine muscle was similar to the pituitary extract obtained from the pars posterior hypophysis of animals.

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