N-{p-[(2,4-Diamino-6-pteridylmethyl)-tosylamino]-benzoyl}- L-glutamic Acid, a Pteroylglutamic Acid Analog

1954 ◽  
Vol 76 (11) ◽  
pp. 3033-3033 ◽  
Author(s):  
Barney J. Magerlein ◽  
David I. Weisblat
Keyword(s):  
Glutamic Acid ◽  
Acid Analog ◽  
Pteroylglutamic Acid

A Glutamic Acid Analog Bearing an Ethylenediamine Moiety Promotes the Cytosolic Delivery of TAT Peptides

2017 ◽  
Vol 46 (6) ◽  
pp. 889-891
Author(s):  
Tadashi Umemoto ◽  
Kotaro Sakamoto ◽  
Yasunori Fukuda ◽  
Yusuke Adachi ◽  
Akiyoshi Tani ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Cytosolic Delivery ◽  
Tat Peptides ◽  
Acid Analog

Utilization of Glutamic Acid in the Presence of High Levels of Pteroylglutamic Acid

1948 ◽  
Vol 67 (4) ◽  
pp. 523-527 ◽  
Author(s):  
A. L. Franklin ◽  
M. Regan ◽  
D. Lewis ◽  
E. L. R. Stokstad ◽  
T. H. Jukes
Keyword(s):  
Glutamic Acid ◽  
Pteroylglutamic Acid

Kainic acid as conformationally constrained glutamic acid analog in peptide synthesis

1995 ◽  
Vol 36 (51) ◽  
pp. 9309-9312 ◽  
Author(s):  
Florinda Artuso ◽  
Giovanni Sindona ◽  
Constantinos Athanassopoulos ◽  
George Stavropoulos ◽  
Dionissios Papaioannou
Keyword(s):  
Glutamic Acid ◽  
Kainic Acid ◽  
Peptide Synthesis ◽  
Conformationally Constrained ◽  
Acid Analog

scholarly journals Design and Synthesis of a New Orthogonally Protected Glutamic Acid Analog and Its Use in the Preparation of High Affinity Polo-like Kinase 1 Polo-box Domain – binding Peptide Macrocycles

2021 ◽  
Author(s):  
David Hymel ◽  
Kohei Tsuji ◽  
Robert A. Grant ◽  
Ramesh M. Chingle ◽  
Dominique L. Kunciw ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Protein Interactions ◽  
Protein Protein Interactions ◽  
Binding Peptide ◽  
Design And Synthesis ◽  
High Affinity ◽  
Acid Analog ◽  
Therapeutic Development

Targeting protein – protein interactions (PPIs) has emerged as important area of discovery for anticancer therapeutic development. In the case of phospho-dependent PPIs, such as the polo-like kinase 1 (Plk1)...

scholarly journals The urinary excretion of orally administered pteroyl-l-glutamic acid by the rat

1971 ◽  
Vol 123 (5) ◽  
pp. 907-914 ◽  
Author(s):  
J. A. Blair ◽  
E. Dransfield
Keyword(s):  
Oral Dose ◽  
Oral Administration ◽  
Urinary Excretion ◽  
Glutamic Acid ◽  
Decomposition Products ◽  
Naturally Occurring ◽  
Pteroylglutamic Acid

1. The urinary excretion of folates after oral administration of [2-14C]pteroyl-l-glutamic acid was studied by assaying the radioactivity in the urine and in materials purified and characterized by t.l.c. 2. Radioactivity excreted was 6.8, 5.9 and 30.7% of the oral dose in the first 24h after doses of 3.1, 32 and 320μg/kg respectively. 3. Extensive decomposition of urinary folates to pteroyl-l-glutamic acid was prevented by antioxidants or collection of urine frozen. 4. At the three dosages, two major and one minor radioactive compounds were isolated. One of the major metabolites was 5-methyltetrahydropteroylglutamic acid. The others were unidentified but were not pteroylglutamic acid, 7,8-dihydro-, 5,6,7,8-tetrahydro-, 5- or 10-formyl-tetrahydro-, 5,10-methylidyne-tetrahydro-, 5-formimidoyl-tetrahydro-, 5,10-methylene-tetrahydro-, 5-methyltetrahydro-pteroylglutamic acid, nor any decomposition products of these compounds formed during isolation. Labelled unconjugated pteridines were absent. 5. Labelled pteroyl-l-glutamic acid was displaced by oral administration of unlabelled pteroyl-l-glutamic acid (1.6mg/kg) when given 3.5h after, but not when given 24h after the labelled dose. 6. The results show that orally administered [2-14C]pteroyl-l-glutamic acid is absorbed without metabolism and is then metabolized into naturally occurring tetrahydro-folates. 7. These findings are discussed with reference to previous work.

Analogs of Pteroylglutamic Acid. IV. Replacement of Glutamic Acid by Other Amino Acids

1949 ◽  
Vol 71 (9) ◽  
pp. 3014-3017 ◽  
Author(s):  
William B. Wright ◽  
Donna B. Cosulich ◽  
Marvin J. Fahrenbach ◽  
Coy W. Waller ◽  
James M. Smith ◽  
...  
Keyword(s):  
Amino Acids ◽  
Glutamic Acid ◽  
Pteroylglutamic Acid
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