Bis-Ammonium Salts. Unsymmetric Derivatives of Substituted Pyridine Bases that Are Potent and Selective Hypotensive Agents1

1957 ◽  
Vol 79 (14) ◽  
pp. 3805-3808 ◽  
Author(s):  
Allan P. Gray ◽  
Wesley L. Archer ◽  
Ernest E. Spinner ◽  
Chester J. Cavallito
2016 ◽  
Vol 11 (3) ◽  
pp. 199
Author(s):  
N.M. Ismagulova ◽  
Zh.S. Nurmaganbetov ◽  
A.Zh. Turmukhambetov ◽  
T.S. Seitembetov ◽  
S.M. Adekenov

The indole alkaloid harmine was extracted from underground part of <em>Peganum harmala L.</em> With the purpose of obtaining the new biological active derivatives on base of alkaloid harmine the chemical modification was carried out. The p-toluolsulfochlorid, p-toluolsulfoacid, hydrochloric, sulfuric, nitric acids, dioxide selenium and phthalic anhydride have been chosen as modifiers. For the first time quaternary ammonium salts, derivatives of N-oxide and N (2)-oxyharminiumphthalate harmine are synthesized. The structure of the synthesized compounds is determined by methods of the spectral analysis and X-ray analysis. Antimicrobic and phagocytosis stimulating activities of isolated alkaloids and their derivatives are investigated.


Author(s):  
M. Solomiychuk

Goal. Selection of combinations of biocomplexes based on Pseudomonas fluorenscens bacteria with stimulant preparations based on various derivatives of ammonium salts of dihydropyrimidine and study of their effectiveness. Methods. Biotechnological methods for the study of bacteria Pseudomonas fluorenscens strain AR-33. The concentration of viable bacteria (CFU/cm3) was determined by the Koch method. Accounts were performed according to generally accepted methods using experimental methods in phytopathology and plant protection. Determined the effectiveness of drugs at different rates of consumption against fungal diseases. Results. Derivatives of ammonium salts of dihydropyrimidine did not show a toxic effect on reducing the concentration of viable cells of strain AR-33 bacteria Pseudomonas fluorescens. The best indicators of the weight of 100 seeds and the number of beans in soybean plants showed a combination: Planriz, v.s. (bacteria of strain AR-33 Pseudomonas fluorescens, 3 ќ 10 9 CFU/cm3) (5 l/ha) + 0.1% solution of ximedon + 0.2% solution of succinic acid + 2 ml of DMAE + 2 ml of DMSO. The use of all combinations of biocomplexes showed the effectiveness of drugs against diseases in the range of 59.31—69.63%. With the use of biocomplexes, due to the fungicidal, immunoprotective and stimulating effect, a yield increase of 1.15—1.7 times relative to the control was recorded. The best yield on potatoes (3.4 t/ ha) was provided by the combination Planriz, v.s. (5 l/ha) + 0.1% solution of ximedon + 0.2% solution of succinic acid + 2 ml of DMAE + 2 ml of DMSO. The effectiveness of the drug against late blight was 79.1%. Conclusions. The use of stimulants and excipients DMAE and DMSO as substances that affect various transmembrane functions, provided an increase in the effectiveness of drugs by 8—14% relative to combinations without their use.


ChemInform ◽  
2010 ◽  
Vol 27 (30) ◽  
pp. no-no
Author(s):  
E. V. BAKHAREVA ◽  
M G. VORONKOV ◽  
M. S. SOROKIN ◽  
V. A. LOPYREV ◽  
S. B. SEREDENIN ◽  
...  

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