Additions and Corrections - Specific Solvent Effects in the Alkylation of Enolate Anions. I. The Alkylation of Sodiomalonic Esters with Alkyl Halides.

1960 ◽  
Vol 82 (24) ◽  
pp. 6429-6431
Author(s):  
Harold Zaugg ◽  
Bruce Horrom ◽  
Sandra Borgwardt
Keyword(s):  
Solvent Effects ◽  
Alkyl Halides

scholarly journals Kinetic solvent effects in the reduction of alkyl halides by {Sm[N(SiMe3)2]2(THF)2}

2018 ◽  
Vol 857 ◽  
pp. 52-57 ◽  
Author(s):  
Tesia V. Chciuk ◽  
Sandeepan Maity ◽  
Robert A. Flowers
Keyword(s):  
Solvent Effects ◽  
Alkyl Halides

Vitamin B12-based elimination of alkyl halides

2020 ◽  
Author(s):  
Julian West ◽  
Alexandros S Pollatos ◽  
Radha Bam
Keyword(s):  
Vitamin B12 ◽  
Alkyl Halides

Fe-Catalyzed Conjunctive Cross-Couplings of Unactivated Alkenes with Grignard Reagents

2020 ◽  
Author(s):  
Lei Liu ◽  
Wes Lee ◽  
Cassandra R. Youshaw ◽  
Mingbin Yuan ◽  
Michael B. Geherty ◽  
...  
Keyword(s):  
Functional Groups ◽  
Cross Coupling ◽  
Alkyl Halides ◽  
Grignard Reagents ◽  
Turnover Frequency ◽  
Diverse Range ◽  
Cascade Cyclization ◽  
Radical Cascade

The first iron-catalyzed three-component cross-coupling of unactivated olefins with alkyl halides and Grignard reagents is reported. The reaction operates under fast turnover frequency and tolerates a diverse range of sp2-hybridized nucleophiles, alkyl halides, and unactivated olefins bearing diverse functional groups to yield the desired 1,2-alkylarylated products with high regiocontrol. Further, we demonstrate that this protocol is amenable for the synthesis of new (hetero)carbocycles including tetrahydrofurans and pyrrolidines via a three-component radical cascade cyclization/arylation that forges three new C-C bonds.

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