A NEW CLASS OF HIGHLY ACTIVE ANTIHISTAMINICS

1960 ◽  
Vol 82 (8) ◽  
pp. 2077-2078 ◽  
Author(s):  
C. F. Huebner ◽  
Ellen Donoghue ◽  
Patricia Wenk ◽  
E. Sury ◽  
J. A. Nelson
Keyword(s):  
New Class ◽  
Highly Active

scholarly journals Cationic ruthenium alkylidene catalysts bearing phosphine ligands

2016 ◽  
Vol 45 (8) ◽  
pp. 3627-3634 ◽  
Author(s):  
Koji Endo ◽  
Robert H. Grubbs
Keyword(s):  
Ionic Liquid ◽  
Phosphine Ligands ◽  
New Class ◽  
Highly Active ◽  
Metathesis Catalysts

The discovery of highly active catalysts and the success of ionic liquid immobilized systems have accelerated attention to a new class of cationic metathesis catalysts.

scholarly journals Effect of the Novel Antifungal Drug F901318 (Olorofim) on Growth and Viability ofAspergillus fumigatus

2018 ◽  
Vol 62 (8) ◽  
Author(s):  
Saskia du Pré ◽  
Nicola Beckmann ◽  
Mariana Cruz Almeida ◽  
Graham E. M. Sibley ◽  
Derek Law ◽  
...  
Keyword(s):  
Prolonged Exposure ◽  
De Novo ◽  
Hyphal Growth ◽  
Cell Lysis ◽  
Antifungal Drug ◽  
The Novel ◽  
Content Type ◽  
New Class ◽  
Highly Active ◽  
Germination And Growth

ABSTRACTF901318 (olorofim) is a novel antifungal drug that is highly active againstAspergillusspecies. Belonging to a new class of antifungals called the orotomides, F901318 targets dihydroorotate dehydrogenase (DHODH) in thede novopyrimidine biosynthesis pathway. In this study, the antifungal effects of F901318 againstAspergillus fumigatuswere investigated. Live cell imaging revealed that, at a concentration of 0.1 μg/ml, F901318 completely inhibited germination, but conidia continued to expand by isotropic growth for >120 h. When this low F901318 concentration was applied to germlings or vegetative hyphae, their elongation was completely inhibited within 10 h. Staining with the fluorescent viability dye bis-(1,3-dibutylbarbituric acid) trimethine oxonol (DiBAC) showed that prolonged exposure to F901318 (>24 h) led to vegetative hyphal swelling and a decrease in hyphal viability through cell lysis. The time-dependent killing of F901318 was further confirmed by measuring the fungal biomass and growth rate in liquid culture. The ability of hyphal growth to recover in drug-free medium after 24 h of exposure to F901318 was strongly impaired compared to that of the untreated control. A longer treatment of 48 h further improved the antifungal effect of F901318. Together, the results of this study indicate that F901318 initially has a fungistatic effect onAspergillusisolates by inhibiting germination and growth, but prolonged exposure is fungicidal through hyphal swelling followed by cell lysis.

A new class of electrocatalysts of supporting Pt on an Engel–Brewer alloy substrate: a demonstration for oxidation of ethylene glycol

2014 ◽  
Vol 50 (85) ◽  
pp. 12981-12984 ◽  
Author(s):  
X. F. Yang ◽  
W. Xu ◽  
M. Li ◽  
B. E. Koel ◽  
J. G. Chen
Keyword(s):  
Ethylene Glycol ◽  
Lattice Mismatch ◽  
Alloy Substrate ◽  
New Class ◽  
Highly Active

A Pt monolayer supported on an Engel–Brewer alloy, Hf–Ir, is highly active in oxidizing ethylene glycol into CO2. This enhanced performance originates from the lattice mismatch between surface Pt and the Hf–Ir support and the highly reducible Hf oxide adjacent to Pt sites.

Phosphine–phosphite, a new class of auxiliaries in highly active and enantioselective hydrogenation

2000 ◽  
pp. 2383-2384 ◽  
Author(s):  
Oscar Pàmies ◽  
Montserrat Diéguez ◽  
Gemma Net ◽  
Aurora Ruiz ◽  
Carmen Claver
Keyword(s):  
Enantioselective Hydrogenation ◽  
New Class ◽  
Highly Active
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