The Secondary Structures of Nucleic Acids in Organic Solvents1

1961 ◽  
Vol 83 (1) ◽  
pp. 138-142 ◽  
Author(s):  
George K. Helmkamp ◽  
Paul O. P. Ts'o
Keyword(s):  
Nucleic Acids ◽  
Secondary Structures

scholarly journals A short peptide that preferentially binds c-MYC G-quadruplex DNA

2020 ◽  
Vol 56 (63) ◽  
pp. 8940-8943 ◽  
Author(s):  
Aisling Minard ◽  
Danielle Morgan ◽  
Federica Raguseo ◽  
Anna Di Porzio ◽  
Denise Liano ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Human Genome ◽  
Promoter Region ◽  
Secondary Structures ◽  
Quadruplex Dna ◽  
Short Peptide ◽  
G Quadruplex

G-quadruplexes are nucleic-acids secondary structures that are highly abundant in the human genome. In this work,we identified a short-peptide that displays selectivity for the G-quadruplex formed in the promoter region of the oncogene c-MYC.

Molybdenum disulfide@5-carboxyfluorescein-probe biosensor for unamplified specific fragment detection in long nucleic acids based on magnetic composite probe-actuated deblocking of secondary structure

2020 ◽  
Vol 12 (39) ◽  
pp. 4813-4822
Author(s):  
Bin Guo ◽  
Yurong Yan ◽  
Lu Fan ◽  
Haiping Wu ◽  
Min Zhao ◽  
...  
Keyword(s):  
Secondary Structure ◽  
Nucleic Acids ◽  
Molybdenum Disulfide ◽  
Secondary Structures ◽  
Magnetic Composite ◽  
Specific Location ◽  
Specific Fragment ◽  
Location Point

Secondary structures in long circulating tumor nucleic acids have potential obstacles for specific location point hybridized detection of gene fragments.

scholarly journals On the binding modes of metal NHC complexes with DNA secondary structures: implications for therapy and imaging

2017 ◽  
Vol 53 (59) ◽  
pp. 8249-8260 ◽  
Author(s):  
Özden Karaca ◽  
Samuel M. Meier-Menches ◽  
Angela Casini ◽  
Fritz E. Kühn
Keyword(s):  
Nucleic Acids ◽  
Secondary Structures ◽  
Binding Modes ◽  
Dna Secondary Structures

This perspective review aims at providing an overview of the most representative examples of bioactive metal NHC complexes reacting with nucleic acidsviadifferent binding modes.

Stabilization of hairpins and bulged secondary structures of nucleic acids by single incorporation of α,β-D-CNA featuring a gauche(+) alpha torsional angle

RSC Advances ◽  
2014 ◽  
Vol 4 (90) ◽  
pp. 48821-48826 ◽  
Author(s):  
Béatrice Gerland ◽  
Pierre Millard ◽  
Christelle Dupouy ◽  
Brice-Loïc Renard ◽  
Jean-Marc Escudier
Keyword(s):  
Nucleic Acids ◽  
Secondary Structures ◽  
Torsional Angle ◽  
Dna Hairpin

A constrained dinucleotide unit featuring a gauche(+) alpha torsional angle configuration was used to stabilize DNA hairpin or bulged structures.

Chemical-biology approaches to probe DNA and RNA G-quadruplex structures in the genome

2020 ◽  
Vol 56 (9) ◽  
pp. 1317-1324 ◽  
Author(s):  
Federica Raguseo ◽  
Souroprobho Chowdhury ◽  
Aisling Minard ◽  
Marco Di Antonio
Keyword(s):  
Nucleic Acids ◽  
Chemical Biology ◽  
Secondary Structures ◽  
Biological Functions ◽  
Physiological Conditions ◽  
Dna And Rna ◽  
G Quadruplex

G-quadruplexes are nucleic-acids secondary structures that can be formed under physiological conditions. In this review, we critically present the most relevant chemical-biology methods to probe the biological functions of G-quadruplex structures.

scholarly journals Convertible and conformationally constrained nucleic acids (C2NAs)

2019 ◽  
Vol 17 (26) ◽  
pp. 6386-6397
Author(s):  
Jean-Marc Escudier ◽  
Corinne Payrastre ◽  
Béatrice Gerland ◽  
Nathalie Tarrat
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Secondary Structures ◽  
Conformationally Constrained

Convertible and Constrained Nucleic Acids (C2NAs) allow for decoration and stabilization of nucleic acid secondary structures such as a duplex when α is locked in the gauche(−) conformation or hairpin when α is constrained to the gauche(+) conformation.

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