The Preparation of All-Trans Uniformly13C-Labeled Retinal via a Modular Total Organic Synthetic Strategy. Emerging Central Contribution of Organic Synthesis toward the Structure and Function Study with Atomic Resolution in Protein Research

2002 ◽  
Vol 124 (22) ◽  
pp. 6324-6334 ◽  
Author(s):  
Alain F. L. Creemers ◽  
Johan Lugtenburg
2005 ◽  
Vol 436 (2) ◽  
pp. 316-322 ◽  
Author(s):  
Xiao-Jia Wang ◽  
Ya-Duo Bai ◽  
Guo-Zhong Zhang ◽  
Ji-Xun Zhao ◽  
Ming Wang ◽  
...  

1993 ◽  
Vol 26 (4) ◽  
pp. 365-421 ◽  
Author(s):  
M. S. P. Sansom

Transport of ions through channels is fundamental to a number of physiological processes, especially the electrical properties of excitable cells (Hille, 1992). To understand this process at a molecular level requires atomic resolution structures of channel proteins.


Biochimie ◽  
1991 ◽  
Vol 73 (6) ◽  
pp. 777-787 ◽  
Author(s):  
E. Afonina ◽  
N. Chichkova ◽  
S. Bogdanova ◽  
A. Bogdanov

Joule ◽  
2018 ◽  
Vol 2 (10) ◽  
pp. 2167-2177 ◽  
Author(s):  
Yuzhang Li ◽  
William Huang ◽  
Yanbin Li ◽  
Allen Pei ◽  
David Thomas Boyle ◽  
...  

2004 ◽  
Vol 32 (3) ◽  
pp. 535-539 ◽  
Author(s):  
S.C.R. Lummis

The 5-HT3 (5-hydroxytryptamine) receptor is a typical member of the Cys-loop family of ligand-gated ion channels. No atomic resolution structures of these proteins have yet been published, and thus structure–function relationships in this family of proteins have been largely determined from experimental evidence combined with the use of homologous proteins and lower resolution images. Here, recent advances in our knowledge of the structure and function of the transmembranous part of the 5-HT3 receptor are reviewed. These show that the pore region, M2, is largely α-helical, and ion selectivity may be controlled by charged amino acid rings at each end of this pore region. The mechanism by which the pore opens is probably similar to that proposed for the nACh receptor, i.e. a twist of M2, caused by rotation in the extracellular domains, removes hydrophobic residues from the ion path.


1986 ◽  
Vol 20 (11) ◽  
pp. 1143-1146 ◽  
Author(s):  
Moshe Berant ◽  
Uri Alon ◽  
Ditza Antebi ◽  
Eric Diamond ◽  
Hedwig Koerner ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document