Asymmetric Synthesis of α-Amino Acids via Cinchona Alkaloid-Catalyzed Kinetic Resolution of Urethane-Protected α-Amino AcidN-Carboxyanhydrides

2001 ◽  
Vol 123 (50) ◽  
pp. 12696-12697 ◽  
Author(s):  
Jianfeng Hang ◽  
Shi-Kai Tian ◽  
Liang Tang ◽  
Li Deng
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
Kinetic Resolution ◽  
Cinchona Alkaloid

Asymmetric synthesis of quaternary α-trifluoromethyl α-amino acids by Ir-catalyzed allylation followed by kinetic resolution

2020 ◽  
Vol 56 (22) ◽  
pp. 3333-3336 ◽  
Author(s):  
Xi-Shang Sun ◽  
Qiu Ou-Yang ◽  
Shi-Ming Xu ◽  
Xing-Heng Wang ◽  
Hai-Yan Tao ◽  
...  
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
Kinetic Resolution ◽  
Asymmetric Allylation ◽  
Sequential Reaction

Facile access to quaternary α-trifluoromethyl α-amino acids has been developed. This sequential reaction involves an Ir-catalyzed asymmetric allylation of α-trifluoromethyl aldimine esters followed by an unprecedented kinetic resolution.

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