Reaction Kinetics of Aliphatic Tertiary β-Chloroethylamines in Dilute Aqueous Solution. I. The Cyclization Process1

1948 ◽  
Vol 70 (1) ◽  
pp. 281-285 ◽  
Author(s):  
Barnett Cohen ◽  
Ervin R. Van Artsdalen ◽  
Joseph Harris
Keyword(s):  
Aqueous Solution ◽  
Reaction Kinetics ◽  
Dilute Aqueous Solution ◽  
Kinetics Of

Fast reaction kinetics of porphyrin dimerization in aqueous solution

1970 ◽  
Vol 92 (11) ◽  
pp. 3312-3316 ◽  
Author(s):  
Radha R. Das ◽  
Robert F. Pasternack ◽  
Robert A. Plane
Keyword(s):  
Aqueous Solution ◽  
Reaction Kinetics ◽  
Fast Reaction ◽  
Kinetics Of

Stability of the Nerve Gas Antidote BIS (4-Hydroxyiminomethyl-1-Pyridinomethyl) Ether Dichloride (Toxogonin®)

1968 ◽  
Vol 2 (9) ◽  
pp. 234-243 ◽  
Author(s):  
Inga Christenson
Keyword(s):  
Aqueous Solution ◽  
Hydrochloric Acid ◽  
Sodium Hydroxide ◽  
Rate Constants ◽  
Kinetics Of Hydrolysis ◽  
Dilute Aqueous Solution ◽  
Nerve Gas ◽  
Ph Range ◽  
Kinetics Of ◽  
Hydrolysis Of

The products and kinetics of hydrolysis of the nerve gas antidote bis(4-hydroxyiminomethyl - 1 - pyridinemethyl) ether dichloride (Toxogonin ®) have been investigated. A survey of these studies is given: The hydrolytic reactions were studied in the pH range 1 M hydrochloric acid to 1 M sodium hydroxide at 25, 45, 75 and 85° C. Rate constants were determined in dilute aqueous solution, generally with an initial Toxogonin concentration of 0.01 mg per ml. In addition, a report is given concerning two-year storage of 25 percent (w/v) Toxogonin solutions at pH 2.5, 3.0 and 3.5. The solutions were stored in glass or polypropylene ampuls at 5, 15, 25 and 45°C. At 5 and 15C° decomposition was negligible, at 25 and 45 °C average decomposition was 1.5 percent and 3.3 percent, respectively.

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