Quinone Imides. XXIII. Addition Reactions of p-Quinonedibenzimide and Related Compounds

1952 ◽  
Vol 74 (23) ◽  
pp. 5872-5876 ◽  
Author(s):  
Roger Adams ◽  
D. S. Acker
Keyword(s):  
Addition Reactions ◽  
Related Compounds

Synthesis of Orthotrithioformates and Related Compounds. Carbanion Formation and Evaluation for 1,4 Addition Reactions with α,β-Unsaturated Ketones

1979 ◽  
Vol 32 (2) ◽  
pp. 353 ◽  
Author(s):  
RAJ Smith ◽  
AR Lal
Keyword(s):  
Addition Reactions ◽  
Unsaturated Ketones ◽  
Related Compounds

The syntheses of potential α-sulfur-substituted carbanion precursors (2a-h) are reported and the results of their subsequent reactions with strong bases are presented. The relatively stable carbanions (3a-d) were made to react with a variety of α,β-unsaturated ketones and the yields of 1,4 and 1,2 addition products were determined.

Carcinogenicity of lactones. IV. Alkylation of analogues of DNA guanine groups such as imidazole, N-methylimidazole, and guanosine by α, β-unsaturated acids

1970 ◽  
Vol 48 (10) ◽  
pp. 1566-1573 ◽  
Author(s):  
J. Bryan Jones ◽  
John M. Young
Keyword(s):  
Michael Addition ◽  
Alkylating Agents ◽  
Addition Reactions ◽  
Hydrolysis Of ◽  
Related Compounds ◽  
The Michael Addition

Studies on the reactions of carcinogenic γ-lactones and related compounds with analogues of guanine DNA residues indicate that the lactones themselves will not effect permanent alkylation of the guanine N-7 position since the Michael addition reactions involved would be readily reversible. In contrast, the α,β-unsaturated acids resulting from hydrolysis of such lactones are effective guanine N-7 alkylating agents owing to zwitterionic stabilization of the corresponding Michael addition products.

Addition Reactions of Acid Anhydrides to Isoquinoline and Its Related Compounds

Heterocycles ◽  
1975 ◽  
Vol 3 (12) ◽  
pp. 1113 ◽  
Author(s):  
Hiroshi Yamanaka ◽  
Takayuki Shiraishi ◽  
Takao Sakamoto
Keyword(s):  
Addition Reactions ◽  
Acid Anhydrides ◽  
Related Compounds
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