Chemiluminescence of Grignard reagents. Some spectroscopic and mechanistic studies

1968 ◽  
Vol 90 (17) ◽  
pp. 4545-4549 ◽  
Author(s):  
Richard L. Bardsley ◽  
David M. Hercules
Keyword(s):  
Grignard Reagents ◽  
Mechanistic Studies

Design and Development of Fe-Catalyzed Intra- and Intermolecular Carbofunctionalization of Vinyl Cyclopropanes

2019 ◽  
Author(s):  
Lei Liu ◽  
Wes Lee ◽  
Mingbin Yuan ◽  
Chris Acha ◽  
Michael B. Geherty ◽  
...  
Keyword(s):  
Bond Formation ◽  
Cross Coupling ◽  
Alkyl Halides ◽  
Grignard Reagents ◽  
Mechanistic Studies ◽  
Radical Intermediates ◽  
Design And Implementation ◽  
Solvent Cage ◽  
Radical Cascade ◽  
Radical Processes

Design and implementation of the first (asymmetric) Fe-catalyzed intra- and intermolecular difunctionalization of vinyl cyclopropanes (VCPs) with alkyl halides and aryl Grignard reagents has been realized via a mechanistically driven approach. Mechanistic studies support the diffusion of the alkyl radical intermediates out of the solvent cage to participate in an intra- or -intermolecular radical cascade with the VCP followed by re-entering the Fe radical cross-coupling cycle to undergo selective C(sp2)-C(sp3) bond formation. Overall, we provide new design principles for Fe-mediated radical processes and underscore the potential of using combined computations and experiments to accelerate the development of challenging transformations.

TEMPO-mediated homocoupling of aryl Grignard reagents: mechanistic studies

2015 ◽  
Vol 13 (9) ◽  
pp. 2762-2767 ◽  
Author(s):  
Sandip Murarka ◽  
Juri Möbus ◽  
Gerhard Erker ◽  
Christian Mück-Lichtenfeld ◽  
Armido Studer
Keyword(s):  
Grignard Reagents ◽  
Computational Studies ◽  
Mechanistic Studies

The mechanism of TEMPO mediated oxidative homo-coupling of aryl Grignard reagents to biphenyls is investigated in detail by experimental and computational studies.

Synthesis of quinolines and acridines by the reaction of 2-(perfluoroalkyl)anilines with lithium and Grignard reagents

2015 ◽  
Vol 21 (3) ◽  
pp. 145-151 ◽  
Author(s):  
Lucjan Strekowski ◽  
Jianguo Zhang ◽  
Jarosław Sączewski ◽  
Ewa Wolińska
Keyword(s):  
Grignard Reagents ◽  
Mechanistic Studies

AbstractThis review summarizes the synthesis of quinolines and acridines by the reactions of anionically activated 2-(perfluoroalkyl)anilines. Mechanistic studies including isolation of the intermediate aza-ortho-xylylene are discussed.

Mechanistic studies on the reaction of nitro- and nitrosoarenes with vinyl Grignard reagents

1991 ◽  
pp. 657 ◽  
Author(s):  
Marcella Bosco ◽  
Renato Dalpozzo ◽  
Giuseppe Bartoli ◽  
Gianni Palmieri ◽  
Marino Petrini
Keyword(s):  
Grignard Reagents ◽  
Mechanistic Studies

Design and Development of Fe-Catalyzed Intra- and Intermolecular Carbofunctionalization of Vinyl Cyclopropanes

2019 ◽  
Author(s):  
Lei Liu ◽  
Wes Lee ◽  
Mingbin Yuan ◽  
Chris Acha ◽  
Michael B. Geherty ◽  
...  
Keyword(s):  
Bond Formation ◽  
Cross Coupling ◽  
Alkyl Halides ◽  
Grignard Reagents ◽  
Mechanistic Studies ◽  
Radical Intermediates ◽  
Design And Implementation ◽  
Solvent Cage ◽  
Radical Cascade ◽  
Radical Processes

Design and implementation of the first (asymmetric) Fe-catalyzed intra- and intermolecular difunctionalization of vinyl cyclopropanes (VCPs) with alkyl halides and aryl Grignard reagents has been realized via a mechanistically driven approach. Mechanistic studies support the diffusion of the alkyl radical intermediates out of the solvent cage to participate in an intra- or -intermolecular radical cascade with the VCP followed by re-entering the Fe radical cross-coupling cycle to undergo selective C(sp2)-C(sp3) bond formation. Overall, we provide new design principles for Fe-mediated radical processes and underscore the potential of using combined computations and experiments to accelerate the development of challenging transformations.

ChemInform Abstract: Mechanistic Studies on the Reaction of Nitro- and Nitrosoarenes with Vinyl Grignard Reagents.

ChemInform ◽  
2010 ◽  
Vol 22 (32) ◽  
pp. no-no
Author(s):  
M. BOSCO ◽  
R. DALPOZZO ◽  
G. BARTOLI ◽  
G. PALMIERI ◽  
M. PETRINI
Keyword(s):  
Grignard Reagents ◽  
Mechanistic Studies

scholarly journals Nickel-catalyzed coupling reaction of alkyl halides with aryl Grignard reagents in the presence of 1,3-butadiene: mechanistic studies of four-component coupling and competing cross-coupling reactions

2018 ◽  
Vol 9 (8) ◽  
pp. 2195-2211 ◽  
Author(s):  
Takanori Iwasaki ◽  
Asuka Fukuoka ◽  
Wataru Yokoyama ◽  
Xin Min ◽  
Ichiro Hisaki ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Alkyl Halides ◽  
Grignard Reagents ◽  
Coupling Reactions ◽  
Mechanistic Studies ◽  
Theoretical Methods ◽  
Bond Forming ◽  
Cross Coupling Reactions ◽  
Detailed Reaction Mechanism

The detailed reaction mechanism of anionic Ni complex-promoted C–C bond forming reactions was clarified by experimental and theoretical methods.

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