The Role of the Quinone in Oxidative Phosphorylation in Mycobacterium phlei. Evidence against Carbon-Hydrogen Bond Cleavage1

1966 ◽  
Vol 88 (16) ◽  
pp. 3868-3870 ◽  
Author(s):  
Clinton D. Snyder ◽  
Samuel J. di Mari ◽  
Henry Rapoport
Keyword(s):  
Hydrogen Bond ◽  
Oxidative Phosphorylation ◽  
Mycobacterium Phlei

The role of the quinone in oxidative phosphorylation. Evidence against carbon-hydrogen bond cleavage

Biochemistry ◽  
1968 ◽  
Vol 7 (6) ◽  
pp. 2301-2317 ◽  
Author(s):  
Samuel J. Di Mari ◽  
Clinton D. Snyder ◽  
Henry. Rapoport
Keyword(s):  
Hydrogen Bond ◽  
Oxidative Phosphorylation ◽  
Bond Cleavage

scholarly journals Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yawei Wang ◽  
Binlin Tang ◽  
Lei Long ◽  
Peng Luo ◽  
Wei Xiang ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Oxidative Phosphorylation ◽  
Near Infrared ◽  
Mitochondrial Metabolism ◽  
Diet Induced Obesity ◽  
Adipose Tissue Macrophages ◽  
Inflammatory Activation ◽  
Treatment Of Obesity ◽  
Pharmaceutical Agents

AbstractPro-inflammatory activation of adipose tissue macrophages (ATMs) is causally linked to obesity and obesity-associated disorders. A number of studies have demonstrated the crucial role of mitochondrial metabolism in macrophage activation. However, there is a lack of pharmaceutical agents to target the mitochondrial metabolism of ATMs for the treatment of obesity-related diseases. Here, we characterize a near-infrared fluorophore (IR-61) that preferentially accumulates in the mitochondria of ATMs and has a therapeutic effect on diet-induced obesity as well as obesity-associated insulin resistance and fatty liver. IR-61 inhibits the classical activation of ATMs by increasing mitochondrial complex levels and oxidative phosphorylation via the ROS/Akt/Acly pathway. Taken together, our findings indicate that specific enhancement of ATMs oxidative phosphorylation improves chronic inflammation and obesity-related disorders. IR-61 might be an anti-inflammatory agent useful for the treatment of obesity-related diseases by targeting the mitochondria of ATMs.

scholarly journals A Rôle of Nuclei in Oxidative Phosphorylation

1953 ◽  
Vol 200 (1) ◽  
pp. 263-269
Author(s):  
R. Bernal Johnson ◽  
W.W. Ackermann ◽  
Leonard E. Keith
Keyword(s):  
Oxidative Phosphorylation

Role of the hydrogen bond donor component for a proper development of novel hydrophobic deep eutectic solvents

2019 ◽  
Vol 281 ◽  
pp. 423-430 ◽  
Author(s):  
Matteo Tiecco ◽  
Federico Cappellini ◽  
Francesco Nicoletti ◽  
Tiziana Del Giacco ◽  
Raimondo Germani ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Deep Eutectic Solvents ◽  
Hydrogen Bond Donor

scholarly journals On the role of hydrogen-bond exchanges in the spectral diffusion of water

2021 ◽  
Vol 154 (6) ◽  
pp. 064501
Author(s):  
Zeke A. Piskulich ◽  
Damien Laage ◽  
Ward H. Thompson
Keyword(s):  
Hydrogen Bond ◽  
Spectral Diffusion

scholarly journals Author Correction: Simultaneous Inhibition of Glycolysis and Oxidative Phosphorylation Triggers a Multi-Fold Increase in Secretion of Exosomes: Possible Role of 2′,3′-cAMP

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Nils Ludwig ◽  
Saigopalakrishna S. Yerneni ◽  
Elizabeth V. Menshikova ◽  
Delbert G. Gillespie ◽  
Edwin K. Jackson ◽  
...  
Keyword(s):  
Oxidative Phosphorylation ◽  
Fold Increase ◽  
Inhibition Of Glycolysis ◽  
Simultaneous Inhibition
Sign in / Sign up

Export Citation Format

Share Document