The Synthesis of the Anomeric 7-D-Ribofuranosyladenines and the Identification of the Nucleoside from Pseudovitamin B12

1963 ◽  
Vol 85 (17) ◽  
pp. 2672-2673 ◽  
Author(s):  
John A. Montgomery ◽  
H. Jeanette. Thomas
Keyword(s):  
Pseudovitamin B12

scholarly journals Pseudovitamin B12 Biosynthesis

1969 ◽  
Vol 244 (7) ◽  
pp. 1667-1671
Author(s):  
H C Friedmann ◽  
J A Fyfe
Keyword(s):  
Pseudovitamin B12

HYDROLYSIS PRODUCTS OF PSEUDOVITAMIN B12

1952 ◽  
Vol 74 (4) ◽  
pp. 1108-1108 ◽  
Author(s):  
H. W. Dion ◽  
D. G. Calkins ◽  
J. J. Pfiffner
Keyword(s):  
Hydrolysis Products ◽  
Pseudovitamin B12

scholarly journals Biological Activity of Pseudovitamin B12 on Cobalamin-Dependent Methylmalonyl-CoA Mutase and Methionine Synthase in Mammalian Cultured COS-7 Cells

Molecules ◽  
2020 ◽  
Vol 25 (14) ◽  
pp. 3268 ◽  
Author(s):  
Tomohiro Bito ◽  
Mariko Bito ◽  
Tomomi Hirooka ◽  
Naho Okamoto ◽  
Naoki Harada ◽  
...  
Keyword(s):  
Biological Activity ◽  
Vitamin B12 ◽  
Mammalian Cells ◽  
Cultured Cells ◽  
Enzymatic Reaction ◽  
Intestinal Bacteria ◽  
Methionine Synthase ◽  
Trace Concentration ◽  
Pseudovitamin B12 ◽  
Transcobalamin Ii

Adenyl cobamide (commonly known as pseudovitamin B12) is synthesized by intestinal bacteria or ingested from edible cyanobacteria. The effect of pseudovitamin B12 on the activities of cobalamin-dependent enzymes in mammalian cells has not been studied well. This study was conducted to investigate the effects of pseudovitamin B12 on the activities of the mammalian vitamin B12-dependent enzymes methionine synthase and methylmalonyl-CoA mutase in cultured mammalian COS-7 cells to determine whether pseudovitamin B12 functions as an inhibitor or a cofactor of these enzymes. Although the hydoroxo form of pseudovitamin B12 functions as a coenzyme for methionine synthase in cultured cells, pseudovitamin B12 does not activate the translation of methionine synthase, unlike the hydroxo form of vitamin B12 does. In the second enzymatic reaction, the adenosyl form of pseudovitamin B12 did not function as a coenzyme or an inhibitor of methylmalonyl-CoA mutase. Experiments on the cellular uptake were conducted with human transcobalamin II and suggested that treatment with a substantial amount of pseudovitamin B12 might inhibit transcobalamin II-mediated absorption of a physiological trace concentration of vitamin B12 present in the medium.

scholarly journals Occurrence of Pseudovitamin B12 and Its Possible Function as the Cofactor of Cobalamin-Dependent Methionine Synthase in a Cyanobacterium Synechocystis sp. PCC6803

2009 ◽  
Vol 55 (6) ◽  
pp. 518-521 ◽  
Author(s):  
Yuri TANIOKA ◽  
Yukinori YABUTA ◽  
Ryoichi YAMAJI ◽  
Shigeru SHIGEOKA ◽  
Yoshihisa NAKANO ◽  
...  
Keyword(s):  
Methionine Synthase ◽  
Pseudovitamin B12 ◽  
Synechocystis Sp

scholarly journals Pseudovitamin B12 is the corrinoid produced byLactobacillus reuteriCRL1098 under anaerobic conditions

FEBS Letters ◽  
2007 ◽  
Vol 581 (25) ◽  
pp. 4865-4870 ◽  
Author(s):  
Filipe Santos ◽  
José L. Vera ◽  
Pedro Lamosa ◽  
Graciela F. de Valdez ◽  
Willem M. de Vos ◽  
...  
Keyword(s):  
Anaerobic Conditions ◽  
Pseudovitamin B12

Pseudovitamin B12 and factor S are the predominant corrinoid compounds in edible cricket products

2021 ◽  
Vol 347 ◽  
pp. 129048
Author(s):  
Naho Okamoto ◽  
Fumi Nagao ◽  
Yukihiro Umebayashi ◽  
Tomohiro Bito ◽  
Pattaneeya Prangthip ◽  
...  
Keyword(s):  
Pseudovitamin B12

scholarly journals Characterization of Vitamin B12 Compounds in Fermented Poultry Manure Fertilizers

Agriculture ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 627
Author(s):  
Hiromi Katsura ◽  
Kyohei Koseki ◽  
Tomohiro Bito ◽  
Shigeo Takenaka ◽  
Fumio Watanabe
Keyword(s):  
Liquid Chromatography ◽  
Vitamin B12 ◽  
High Performance ◽  
Organic Fertilizer ◽  
Poultry Manure ◽  
Dry Weight ◽  
Ionization Mass ◽  
Rf Values ◽  
Pseudovitamin B12

(1) Background: Currently, no data are available on the vitamin B12 content of an organic fertilizer product, viz. fermented poultry manure, or whether the organic fertilizer product contains vitamin B12 or inactive corrinoids (or both). (2) Methods: This study conducted a microbiological assay to determine the vitamin B12 content of various commercially available fermented poultry manure fertilizer products. (3) Results: The results varied from 1.4 μg to approximately 20 μg per 100 g of dry weight. In the bioautography analysis, selected products had two positive spots with identical Rf values of vitamin B12 and pseudovitamin B12. High-performance liquid chromatography and liquid chromatography/electrospray ionization−mass spectrometry analyses of the selected products indicated that these fertilizers primarily contained vitamin B12. They also contained minor inactive cobamides such as pseudovitamin B12, 2-methyladenyl cobamide, and 2-methylmercaptoadenyl cobamide. (4) Conclusions: These results suggested that edible plants would enrich vitamin B12 using fermented poultry manure organic fertilizer products.

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