Chemical transformations with regenerable, polymer-supported trisubstituted phosphine dichlorides. Efficacious incorporation of phosphorus reagents on polymer supports

1974 ◽  
Vol 96 (20) ◽  
pp. 6469-6475 ◽  
Author(s):  
Howard M. Relles ◽  
Robert W. Schluenz
Keyword(s):  
Chemical Transformations ◽  
Polymer Supports ◽  
Polymer Supported

scholarly journals An Amphiphilic Polymer-Supported Strategy Enables Chemical Transformations Under Anhydrous Conditions for DNA-Encoded Library Synthesis

2019 ◽  
Author(s):  
Yves Ruff ◽  
Roberto Martinez ◽  
Xavier Pellé ◽  
Pierre Nimsgern ◽  
Pascale Fille ◽  
...  
Keyword(s):  
Small Molecules ◽  
Organic Solvents ◽  
Cross Coupling ◽  
Amphiphilic Polymer ◽  
Aryl Halides ◽  
Chemical Transformations ◽  
Library Synthesis ◽  
Catch And Release ◽  
Dna Conjugates ◽  
Polymer Supported

Herein, we describe the development of a practical catch-and release methodology utilizing a cationic, amphiphilic PEG-based polymer to perform chemical transformations on immobilized DNA conjugates under anhydrous conditions. We demonstrate the usefulness of our APTAC (<u>a</u>mphiphilic <u>p</u>olymer-facilitated <u>t</u>ransformations under <u>a</u>nhydrous <u>c</u>onditions) approach by performing several challenging transformations on DNA-conjugated small molecules in pure organic solvents: the addition of a carbanion equivalent to a DNA-conjugated ketone in tetrahydrofuran, the synthesis of saturated heterocycles using the tin (Sn) amine protocol (SnAP) in dichloromethane and the dual-catalytic (Ir/Ni) metallaphotoredox decarboxylative cross-coupling of carboxylic acids to DNA-conjugated aryl halides in DMSO. In addition, we demonstrate the feasibility of the latter in multititer-plate format.

Soluble polymer-supported organocatalysts

2012 ◽  
Vol 85 (3) ◽  
pp. 493-509 ◽  
Author(s):  
Yun-Chin Yang ◽  
David E. Bergbreiter
Keyword(s):  
Transition Metal ◽  
Organic Synthesis ◽  
Metal Catalysts ◽  
Transition Metal Catalysts ◽  
Soluble Polymer ◽  
Soluble Polymers ◽  
The Past ◽  
Polymer Supports ◽  
Polymer Supported ◽  
Simple Product

Organocatalysts have been extensively studied for the past few decades as alternatives to transition-metal catalysts. Immobilizing organocatalysts on polymer supports allows easy recovery and simple product purification after a reaction. Select examples of recent reports that describe the potential advantages of using soluble polymers to prepare soluble polymer-supported organocatalysts useful in organic synthesis are reviewed.

scholarly journals David Colin Sherrington. 5 March 1945—4 October 2014

2017 ◽  
Vol 64 ◽  
pp. 367-385
Author(s):  
Randal W. Richards ◽  
Philip Hodge
Keyword(s):  
Cationic Polymerization ◽  
Scientific Activity ◽  
Early Years ◽  
Porous Polymer ◽  
Valuable Insight ◽  
Research Career ◽  
Polymer Supports ◽  
Reactive Polymers ◽  
Polymer Supported

David Colin Sherrington began life as a Liverpool docker's son and became an internationally recognized authority on reactive polymers and using polymer-supported reagents in novel applications. His research career began at University of Liverpool with his PhD work on the mechanisms of cationic polymerization. From 1972 until retirement in 2010, Strathclyde University was his chief research base. In the very early years he continued with mechanistic and kinetic studies of cationic polymerization, but soon moved to the field of polymer-supported reactions and reagents, to which he devoted the rest of his research career. An important contribution to the direction of his scientific activity was the secondment years he spent at Unilever, where he became involved in polymeric high internal phase emulsions (polyHIPEs). In the following years, he devoted much effort to accurate characterization of these and other porous polymer supports, frequently involving him in learning new techniques (e.g. neutron scattering). An important feature was the use of polymer supports to catalyse oxidation reactions, especially olefin epoxidation. He gained valuable insight into many aspects of his research from the many visiting professorships over his career. He was involved on the editorial board of Reactive Polymers continuously from 1982 until 2010 and he was awarded many honours. His free time was mainly devoted to fishing, particularly for salmon, an activity he shared with his wife and a group of friends for many years. His warmth, intellect and clear interest in the careers of his research students were key components in creating the polymer ‘family’ to which they belonged. His years of retirement were saddened by multiple system atrophy, a devastating illness throughout which he was cared for by Val, his wife.

scholarly journals An Amphiphilic Polymer-Supported Strategy Enables Chemical Transformations Under Anhydrous Conditions for DNA-Encoded Library Synthesis

2019 ◽  
Author(s):  
Yves Ruff ◽  
Roberto Martinez ◽  
Xavier Pellé ◽  
Pierre Nimsgern ◽  
Maxim Ratnikov ◽  
...  
Keyword(s):  
Small Molecules ◽  
Organic Solvents ◽  
Cross Coupling ◽  
Amphiphilic Polymer ◽  
Aryl Halides ◽  
Chemical Transformations ◽  
Library Synthesis ◽  
Catch And Release ◽  
Dna Conjugates ◽  
Polymer Supported

Herein, we describe the development of a practical catch-and release methodology utilizing a cationic, amphiphilic PEG-based polymer to perform chemical transformations on immobilized DNA conjugates under anhydrous conditions. We demonstrate the usefulness of our APTAC (<u>a</u>mphiphilic <u>p</u>olymer-facilitated <u>t</u>ransformations under <u>a</u>nhydrous <u>c</u>onditions) approach by performing several challenging transformations on DNA-conjugated small molecules in pure organic solvents: the addition of a carbanion equivalent to a DNA-conjugated ketone in tetrahydrofuran, the synthesis of saturated heterocycles using the tin (Sn) amine protocol (SnAP) in dichloromethane and the dual-catalytic (Ir/Ni) metallaphotoredox decarboxylative cross-coupling of carboxylic acids to DNA-conjugated aryl halides in DMSO. In addition, we demonstrate the feasibility of the latter in multititer-plate format.

scholarly journals An Amphiphilic Polymer-Supported Strategy Enables Chemical Transformations Under Anhydrous Conditions for DNA-Encoded Library Synthesis

2019 ◽  
Author(s):  
Yves Ruff ◽  
Roberto Martinez ◽  
Xavier Pellé ◽  
Pierre Nimsgern ◽  
Maxim Ratnikov ◽  
...  
Keyword(s):  
Small Molecules ◽  
Organic Solvents ◽  
Cross Coupling ◽  
Amphiphilic Polymer ◽  
Aryl Halides ◽  
Chemical Transformations ◽  
Library Synthesis ◽  
Catch And Release ◽  
Dna Conjugates ◽  
Polymer Supported

Herein, we describe the development of a practical catch-and release methodology utilizing a cationic, amphiphilic PEG-based polymer to perform chemical transformations on immobilized DNA conjugates under anhydrous conditions. We demonstrate the usefulness of our APTAC (<u>a</u>mphiphilic <u>p</u>olymer-facilitated <u>t</u>ransformations under <u>a</u>nhydrous <u>c</u>onditions) approach by performing several challenging transformations on DNA-conjugated small molecules in pure organic solvents: the addition of a carbanion equivalent to a DNA-conjugated ketone in tetrahydrofuran, the synthesis of saturated heterocycles using the tin (Sn) amine protocol (SnAP) in dichloromethane and the dual-catalytic (Ir/Ni) metallaphotoredox decarboxylative cross-coupling of carboxylic acids to DNA-conjugated aryl halides in DMSO. In addition, we demonstrate the feasibility of the latter in multititer-plate format.

scholarly journals An Amphiphilic Polymer-Supported Strategy Enables Chemical Transformations under Anhydrous Conditions for DNA-Encoded Library Synthesis

2020 ◽  
Vol 22 (3) ◽  
pp. 120-128 ◽  
Author(s):  
Yves Ruff ◽  
Roberto Martinez ◽  
Xavier Pellé ◽  
Pierre Nimsgern ◽  
Pascale Fille ◽  
...  
Keyword(s):  
Amphiphilic Polymer ◽  
Chemical Transformations ◽  
Library Synthesis ◽  
Polymer Supported

Polymer-Supported Membranes: Physical Models of Cell Surfaces

MRS Bulletin ◽  
2006 ◽  
Vol 31 (7) ◽  
pp. 513-520 ◽  
Author(s):  
Motomu Tanaka
Keyword(s):  
Materials Science ◽  
Inorganic Materials ◽  
Physical Models ◽  
Supported Membranes ◽  
Supported Membrane ◽  
Polymer Supports ◽  
Thin Polymer ◽  
Solid Substrates ◽  
Polymer Supported ◽  
Soft Biological Materials

The functional modification of solid surfaces with plasma membrane models has been drawing increasing attention as a straightforward strategy to bridge soft biological materials and hard inorganic materials. Planar model membranes can be deposited either directly on solid substrates (solid-supported membranes), or on ultrathin polymer supports (polymer-supported membranes) that mimic the generic role of the extracellular matrix and the cell surface. The first part of this review provides an overview of advances in the fabrication of polymer-supported membranes. The middle section describes how such thin polymer interlayers can physically modulate the membrane–substrate contact. The last section introduces several methods to localize membranes and membrane proteins. Finally, some ideas are presented on combining supported membrane concepts with semiconductor technology toward applications in materials science.

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