Mechanisms of elimination reactions. XXIII. Stereochemistry of elimination reactions of 3-hexyl tosylate and fluoride. Role of ion pairing

1974 ◽  
Vol 96 (12) ◽  
pp. 3918-3920 ◽  
Author(s):  
John K. Borchardt ◽  
Jhan C. Swanson ◽  
William H. Saunders
Keyword(s):  
Ion Pairing ◽  
Elimination Reactions

ChemInform Abstract: A MCSCF Study of Homoaromaticity and the Role of Ion Pairing in the Stabilization of Carbanions.

ChemInform ◽  
1987 ◽  
Vol 18 (10) ◽  
Author(s):  
R. LINDH ◽  
B. O. ROOS ◽  
G. JONSAELL ◽  
P. AHLBERG
Keyword(s):  
Ion Pairing

Corrigendum: Counterion Specificity of Polyelectrolyte Brushes: Role of Specific Ion-Pairing Interactions

ChemPhysChem ◽  
2018 ◽  
Vol 19 (15) ◽  
pp. 1930-1930
Author(s):  
Ran Kou ◽  
Jian Zhang ◽  
Zhen Chen ◽  
Guangming Liu
Keyword(s):  
Ion Pairing ◽  
Polyelectrolyte Brushes ◽  
Pairing Interactions

scholarly journals Targeted live-cell nuclear delivery of the DNA ‘light-switching’ Ru(II) complex via ion-pairing with chlorophenolate counter-anions: the critical role of binding stability and lipophilicity of the ion-pairing complexes

2019 ◽  
Vol 47 (20) ◽  
pp. 10520-10528 ◽  
Author(s):  
Xi-Juan Chao ◽  
Miao Tang ◽  
Rong Huang ◽  
Chun-Hua Huang ◽  
Jie Shao ◽  
...  
Keyword(s):  
Diffusion Mechanism ◽  
Critical Role ◽  
Ion Pairing ◽  
Chlorinated Phenols ◽  
Cellular Targets ◽  
Nuclear Uptake ◽  
Active Metal ◽  
Physicochemical Factors ◽  
Better Than

Abstract We have found recently that nuclear uptake of the cell-impermeable DNA light-switching Ru(II)-polypyridyl cationic complexes such as [Ru(bpy)2(dppz)]Cl2 was remarkably enhanced by pentachlorophenol (PCP), by forming ion-pairing complexes via a passive diffusion mechanism. However, it is not clear whether the enhanced nuclear uptake of [Ru(bpy)2(dppz)]2+ is only limited to PCP, or it is a general phenomenon for other highly chlorinated phenols (HCPs); and if so, what are the major physicochemical factors in determining nuclear uptake? Here, we found that the nuclear uptake of [Ru(bpy)2(dppz)]2+ can also be facilitated by other two groups of HCPs including three tetrachlorophenol (TeCP) and six trichlorophenol (TCP) isomers. Interestingly and unexpectedly, 2,3,4,5-TeCP was found to be the most effective one for nuclear delivery of [Ru(bpy)2(dppz)]2+, which is even better than the most-highly chlorinated PCP, and much better than its two other TeCP isomers. Further studies showed that the nuclear uptake of [Ru(bpy)2(dppz)]2+ was positively correlated with the binding stability, but to our surprise, inversely correlated with the lipophilicity of the ion-pairing complexes formed between [Ru(bpy)2(dppz)]Cl2 and HCPs. These findings should provide new perspectives for future investigations on using ion-pairing as an effective method for delivering other bio-active metal complexes into their intended cellular targets.

Experimental and Computational Studies of Unimolecular 1,1-HX (X = F, Cl) Elimination Reactions of C2D5CHFCl: Role of Carbene:HF and HCl Adducts in the Exit Channel of RCHFCl and RCHCl2Reactions

2019 ◽  
Vol 123 (13) ◽  
pp. 2621-2633 ◽  
Author(s):  
Blanton R. Gillespie ◽  
Chaitanya A. Patel ◽  
Mallory M. Rothrock ◽  
George L. Heard ◽  
D. W. Setser ◽  
...  
Keyword(s):  
Computational Studies ◽  
Exit Channel ◽  
Elimination Reactions
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