Sceletium alkaloids. IV. Biosynthesis of mesembrine and related alkaloids. Amino acid precursors

1971 ◽  
Vol 93 (15) ◽  
pp. 3752-3758 ◽  
Author(s):  
P. W. Jeffs ◽  
W. C. Archie ◽  
Richard L. Hawks ◽  
D. S. Farrier
Keyword(s):  
Amino Acid ◽  
Amino Acid Precursors

scholarly journals Arcopilus aureus MaC7A as a New Source of Resveratrol: Assessment of Amino Acid Precursors, Volatiles, and Fungal Enzymes for Boosting Resveratrol Production in Batch Cultures

2021 ◽  
Vol 11 (10) ◽  
pp. 4583
Author(s):  
Nemesio Villa-Ruano ◽  
Luis Ángel Morales-Mora ◽  
Jenaro Leocadio Varela-Caselis ◽  
Antonio Rivera ◽  
María de los Ángeles Valencia de Ita ◽  
...  
Keyword(s):  
Amino Acid ◽  
Filamentous Fungi ◽  
Hydrolytic Enzymes ◽  
Glucanase Activity ◽  
Fungal Enzymes ◽  
Activity Increase ◽  
Batch Cultures ◽  
Low Concentrations ◽  
Chemical Factors ◽  
Amino Acid Precursors

The chemical factors that regulate the synthesis of resveratrol (RV) in filamentous fungi are still unknown. This work reports on the RV production by Arcopilus aureus MaC7A under controlled conditions and the effect of amino acid precursors (PHE and TYR), monoterpenes (limonone, camphor, citral, thymol, menthol), and mixtures of hydrolytic enzymes (Glucanex) as elicitors for boosting fungal RV. Batch cultures with variable concentrations of PHE and TYR (50–500 mg L−1) stimulated RV production from 127.9 ± 4.6 to 221.8 ± 5.2 mg L−1 in basic cultures developed in PDB (pH 7) added with 10 g L−1 peptone at 30 °C. Maximum levels of RV and biomass were maintained during days 6–8 under these conditions, whereas a dramatic RV decrease was observed from days 10–12 without any loss of biomass. Among the tested volatiles, citral (50 mg L−1) enhanced RV production until 187.8 ± 2.2 mg L−1 in basic cultures, but better results were obtained with Glucanex (100 mg L−1; 198.3 ± 7.6 mg L−1 RV). Optimized batch cultures containing TYR (200 mg L−1), citral (50 mg L−1), thymol (50 mg L−1), and Glucanex (100 mg L−1) produced up to 237.6 ± 4.7 mg L−1 of RV. Our results suggest that low concentrations of volatiles and mixtures of isoenzymes with β-1, 3 glucanase activity increase the biosynthesis of fungal RV produced by A. aureus MaC7A in batch cultures.

Recyclable BINOL–quinine–squaramide as a highly efficient organocatalyst for α-amination of 1,3-dicarbonyl compounds and α-cyanoacetates

RSC Advances ◽  
2015 ◽  
Vol 5 (31) ◽  
pp. 24392-24398 ◽  
Author(s):  
Yongzhi Gao ◽  
Bin Liu ◽  
Hai-Bing Zhou ◽  
Wei Wang ◽  
Chune Dong
Keyword(s):  
Amino Acid ◽  
Dicarbonyl Compounds ◽  
Highly Efficient ◽  
Amino Acid Precursors

An efficient organocatalytic asymmetric α-amination of 1,3-dicarbonyl and α-cyanoacetates compounds towards chiral α-amino acid precursors is reported.

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