Total Synthesis of FR901464. Convergent Assembly of Chiral Components Prepared by Asymmetric Catalysis

2000 ◽  
Vol 122 (42) ◽  
pp. 10482-10483 ◽  
Author(s):  
Christopher F. Thompson ◽  
Timothy F. Jamison ◽  
Eric N. Jacobsen
Keyword(s):  
Total Synthesis ◽  
Asymmetric Catalysis ◽  
Convergent Assembly

ChemInform Abstract: Total Synthesis of FR901464. Convergent Assembly of Chiral Components Prepared by Asymmetric Catalysis.

ChemInform ◽  
2001 ◽  
Vol 32 (10) ◽  
pp. no-no
Author(s):  
Christopher F. Thompson ◽  
Timothy F. Jamison ◽  
Eric N. Jacobsen
Keyword(s):  
Total Synthesis ◽  
Asymmetric Catalysis ◽  
Convergent Assembly

scholarly journals Organocatalytic Asymmetric Tandem/Domino Reactions Towards Access to Bioactive Products

2021 ◽  
Vol 25 ◽  
Author(s):  
Hélène Pellissier
Keyword(s):  
Total Synthesis ◽  
Asymmetric Catalysis ◽  
Biologically Active ◽  
Direct Access ◽  
Tandem Reactions ◽  
Domino Reactions ◽  
Complex Molecules ◽  
Total Syntheses ◽  
Key Steps ◽  
Simple Materials

: Tandem and domino reactions constitute economic routes to complex molecules starting from simple materials. Especially, combining these powerful procedures to asymmetric catalysis allow a direct access to many elaborated chiral products, including important key intermediates in total syntheses of important biologically active compounds. A range of various types of chiral organocatalysts have already been successfully applied to such syntheses. This review presents major developments in the total synthesis of bioactive products based on the use of enantioselective organocatalytic domino/tandem reactions as key steps. It is divided into three parts, dealing successively with syntheses based on organocatalytic asymmetric Michael-initiated domino reactions as key steps; aldol-initiated domino/tandem reactions and other domino reactions.

Total synthesis and structure revision of chrysamide B

2018 ◽  
Vol 5 (23) ◽  
pp. 3402-3405 ◽  
Author(s):  
Jinhong Chen ◽  
Junfang Li ◽  
Longqing Zhu ◽  
Xue Peng ◽  
Yiyue Feng ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Epoxy Acid ◽  
Structure Revision ◽  
Convergent Assembly

Total synthesis and structure revision of chrysamide B are described, the strategy features a convergent assembly of the chiral piperazine core and epoxy-acid.

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