Substitutive intramolecular carbonyl insertion in a carbomolybdate cluster: formation of a polycentric, conformationally flexible anion binding cavity

1980 ◽  
Vol 102 (18) ◽  
pp. 5971-5973 ◽  
Author(s):  
V. W. Day ◽  
M. R. Thompson ◽  
C. S. Day ◽  
W. G. Klemperer ◽  
R. S. Liu
Keyword(s):  
Cluster Formation ◽  
Anion Binding ◽  
Binding Cavity

Magnetic susceptibility of alkali n -butyrates and isovalerates near their melting points

1975 ◽  
Vol 342 (1628) ◽  
pp. 39-49 ◽  
Keyword(s):  
Magnetic Susceptibility ◽  
Molten Salts ◽  
Diamagnetic Susceptibility ◽  
Cluster Formation ◽  
Anion Binding ◽  
Melting Transition ◽  
Melting Points ◽  
Clearing Point ◽  
Precursor Effects ◽  
Transition Behaviour

Various physical properties of alkali carboxylates can be used to study precursor effects immediately below or above their melting points. The present paper describes unusual pre-transition behaviour observed in the magnetic susceptibility of molten n -butyrates and isovalerates. This takes the form of a transitory enhancement of diamagnetic susceptibility, by nearly 10% in some cases, when the isotropic melt is cooled through the clearing point and into the mesophase region while a magnetic field (up to 1 T(10 4 G)) is applied. No corresponding changes are observed on taking the salt through the same temperature range but in the inverse direction. Again, no corresponding change is observed with an alkali carboxylate which shows no mesophase melting transition. Present findings can be accounted for on the assumption of cluster formation in the molten salts as these approach their upper melting points, which is also indicated by other evidence. The (transient) enhancement of molecular diamagnetism in this region of temperature may also indicate transient perturbations in the actual cation-anion binding near the transition temperature.

scholarly journals Anion Binding Studies on Receptors Derived from the Indolo[2,3-a]carbazole Scaffold Having Different Binding Cavity Sizes

Sensors ◽  
2014 ◽  
Vol 14 (8) ◽  
pp. 14038-14049 ◽  
Author(s):  
Guzmán Sánchez ◽  
David Curiel ◽  
Alberto Tárraga ◽  
Pedro Molina
Keyword(s):  
Anion Binding ◽  
Binding Studies ◽  
Binding Cavity

Engineering an Anion-Binding Cavity in Antichymotrypsin Modulates the “Spring-Loaded” Serpin−Protease Interaction†

Biochemistry ◽  
1998 ◽  
Vol 37 (10) ◽  
pp. 3297-3304 ◽  
Author(s):  
Christine M. Lukacs ◽  
Harvey Rubin ◽  
David W. Christianson
Keyword(s):  
Anion Binding ◽  
Binding Cavity

The Ability of Thrombin Inhibitors to Reduce the Thrombin Activity Generated in Plasma on Extrinsic and Intrinsic Activation

1997 ◽  
Vol 77 (03) ◽  
pp. 498-503 ◽  
Author(s):  
D Prasa ◽  
L Svendsen ◽  
J Stürzebecher
Keyword(s):  
Active Site ◽  
Thrombin Generation ◽  
Anion Binding ◽  
Thrombin Inhibitors ◽  
Coagulation System ◽  
Thrombin Activity ◽  
Continuous Registration ◽  
High Concentrations ◽  
20 Nm ◽  
Generation Test

SummaryIn a thrombin generation test with continuous registration of thrombin activity in plasma we studied the ability of a variety of thrombin inhibitors of different type and mechanism of action to influence the activity of thrombin after activation of the coagulation system. Depending on the inhibitor, the peak of thrombin activity is delayed and/or reduced.By blocking the active site of generated thrombin inhibitors cause a concentration dependent reduction of the thrombin peak and inhibit feed-back reactions of thrombin resulting in a delay of thrombin generation. Highly potent synthetic active-site directed inhibitors (Ki ≤ 20 nM) reduce the thrombin activity formed in plasma after extrinsic or intrinsic activation with the same efficiency (IC50 0.1 - 0.6 μM) as hirudin. The delay and reduction of thrombin generation by inhibitors of the anion-binding exosite 1 of thrombin is only attributed to an inhibition of feed-back reactions of thrombin. For a 50% reduction of thrombin activity in plasma by this type of inhibitors relatively high concentrations were determined.

General Cluster Sorption Isotherm

2020 ◽  
Author(s):  
Christoph Buttersack
Keyword(s):  
Density Functional ◽  
Capillary Condensation ◽  
Cluster Formation ◽  
Full Range ◽  
Full Description ◽  
Cross Sectional ◽  
Macroporous Silica ◽  
Isotherm Equation ◽  
Type Iv ◽  
Classical Thermodynamics

<p>Adsorption isotherms are an essential tool in chemical physics of surfaces. However, several approaches based on a different theoretical basis exist and for isotherms including capillary condensation existing approaches can fail. Here, a general isotherm equation is derived and applied to literature data both concerning type IV isotherms of argon and nitrogen in ordered mesoporous silica, and type II isotherms of disordered macroporous silica. The new isotherm covers the full range of partial pressure (10<sup>-6</sup> - 0.7). It relies firstly on the classical thermodynamics of cluster formation, secondly on a relationship defining the free energy during the increase of the cluster size. That equation replaces the Lennard-Jones potentials used in the classical density functional theory. The determination of surface areas is not possible by this isotherm because the cross-sectional area of a cluster is unknown. Based on the full description of type IV isotherms, most known isotherms are accessible by respective simplifications. </p>

Cambiarenes: Single-Step Synthesis and Anion Binding of a Clip- Shaped Macrocycle with a Redox-Active Core

2019 ◽  
Author(s):  
Riley J. Petersen ◽  
Brett J. Rozeboom ◽  
Shalisa Oburn ◽  
Nolan Blythe ◽  
Tanner Rathje ◽  
...  
Keyword(s):  
Electron Density ◽  
Single Step ◽  
Anion Binding ◽  
Host Molecule ◽  
Selective Binding ◽  
The Core ◽  
Redox Active ◽  
Active Core ◽  
Guest Binding

<div>We report the synthesis of a novel macrocyclic host molecule that forms in a single step from commercially available starting materials. The core of the macrocycle backbone possesses two quinone rings and, thus, is redox-active. Host-guest binding involving the clip-shaped cavity indicates selective binding of pyridine <i>N</i>-oxides based of the electron density of and steric bulk of the anionic oxygen.</div>

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