Total synthesis and revised structural assignment of (+)-furanomycin

1980 ◽  
Vol 102 (2) ◽  
pp. 887-889 ◽  
Author(s):  
Madeleine M. Joullie ◽  
Pen C. Wang ◽  
J. Edward Semple
Keyword(s):  
Total Synthesis ◽  
Structural Assignment

Total Synthesis of Trioxacarcins DC-45-A1, A, D, C, and C7″-epi-C and Full Structural Assignment of Trioxacarcin C

2016 ◽  
Vol 138 (9) ◽  
pp. 3118-3124 ◽  
Author(s):  
K. C. Nicolaou ◽  
Quan Cai ◽  
Hongbao Sun ◽  
Bo Qin ◽  
Shugao Zhu
Keyword(s):  
Total Synthesis ◽  
Structural Assignment

scholarly journals De novo synthesis, structural assignment and biological evaluation of pseudopaline, a metallophore produced by Pseudomonas aeruginosa

2019 ◽  
Vol 10 (27) ◽  
pp. 6635-6641 ◽  
Author(s):  
Jian Zhang ◽  
Tianhu Zhao ◽  
Rongwen Yang ◽  
Ittipon Siridechakorn ◽  
Sanshan Wang ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Total Synthesis ◽  
Natural Product ◽  
Absolute Configuration ◽  
De Novo ◽  
Biological Evaluation ◽  
De Novo Synthesis ◽  
Structural Assignment ◽  
The Absolute

The first total synthesis and isolation of pseudopaline was reported, which allows determination and confirmation of the absolute configuration of the natural product.

Isolation and Complete Structural Assignment of Lycopodium Alkaloid Cernupalhine A: Theoretical Prediction and Total Synthesis Validation

2014 ◽  
Vol 16 (10) ◽  
pp. 2700-2703 ◽  
Author(s):  
Liao-Bin Dong ◽  
Ya-Nan Wu ◽  
Shi-Zhi Jiang ◽  
Xing-De Wu ◽  
Juan He ◽  
...  
Keyword(s):  
Theoretical Prediction ◽  
Total Synthesis ◽  
Structural Assignment ◽  
Lycopodium Alkaloid

Total Synthesis and Structural Assignment of Curvicollide C

2017 ◽  
Vol 19 (16) ◽  
pp. 4391-4394 ◽  
Author(s):  
Valeska von Kiedrowski ◽  
Florian Quentin ◽  
Martin Hiersemann
Keyword(s):  
Total Synthesis ◽  
Structural Assignment

First Total Synthesis of Pamamycin-621D

2018 ◽  
Vol 15 (1) ◽  
pp. 105-109 ◽  
Author(s):  
Hassan Norouzi-Arasi ◽  
Xavier J. Salom-Roig ◽  
Steve Lanners ◽  
Gilles Hanquet
Keyword(s):  
Total Synthesis ◽  
Optical Rotation ◽  
Large Family ◽  
Synthetic Approach ◽  
General Strategy ◽  
Structural Assignment ◽  
12 Steps ◽  
Aldol Addition ◽  
Additional Support ◽  
First Time

Aim and Objective: The objective of our work was to synthesize and fully characterize Pamamycin- 621D, one of the less abundant members of a large family of macrodiolides with antimycobacterial properties, which had never been synthesized before. Furthermore, we also wished to improve our general strategy by using a new unsaturated precursor. Materials and Method: A new unsaturated ethylketone precursor was prepared using alkene cross metathesis, and a convergent and flexible strategy based on a key diastereoselective aldol addition was implemented to afford pamamycin-621D in 12 steps from that precursor. Results: Pamamycin-621D has been obtained and fully characterized for the first time. The structure of pamamycin-621D was confirmed by HRMS and comparison of 1H-NMR spectra with the natural pamamycin- 621D. Both optical rotation and 13C-NMR had not been published previously due to lack of material, and the latter are reported here for the first time. Given the scarce characterization available previously, our synthesis also gives additional support to the initial structural assignment of pamamycin-621D. A significant improvement of the key aldol addition via the use of a new unsaturated precursor is also reported. Conclusion: The work described above constitutes the first total synthesis of pamamycin-621D and has enabled us to fully characterize this scarcely available natural product. More importantly, this work highlights the fact that our synthetic approach provides ready access to various members of the pamamycin family, allowing possible studies on structure-activity relationships and mode of action of even the least abundant of these natural products. The synthesis of other pamamycin congeners and biological investigations will be published in due course.

scholarly journals Total Synthesis and Complete Structural Assignment of Thiocillin I

2011 ◽  
Vol 133 (15) ◽  
pp. 5900-5904 ◽  
Author(s):  
Virender S. Aulakh ◽  
Marco A. Ciufolini
Keyword(s):  
Total Synthesis ◽  
Structural Assignment
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