Molecular activation with low-intensity CW infrared laser radiation. Multiphoton dissociation of ions derived from diethyl ether

1979 ◽  
Vol 101 (19) ◽  
pp. 5503-5512 ◽  
Author(s):  
D. S. Bomse ◽  
R. L. Woodin ◽  
J. L. Beauchamp
Keyword(s):  
Laser Radiation ◽  
Diethyl Ether ◽  
Infrared Laser ◽  
Low Intensity ◽  
Multiphoton Dissociation ◽  
Molecular Activation

scholarly journals STUDY OF THE INFLUENCE OF LOW-INTENSITY INFRARED LASER RADIATION ON CONCENTRATION OF DICLOFENAC SODIUM IN RATS’ PLASMA BY THE METHOD OF HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

2016 ◽  
Author(s):  
L. V. Brun ◽  
V. I. Makolinets
Keyword(s):  
Body Weight ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Laser Radiation ◽  
Drug Administration ◽  
High Performance ◽  
Diclofenac Sodium ◽  
Infrared Laser ◽  
Male Rats ◽  
Low Intensity

The aim of this study is to determine the influence of low-intensity infrared laser radiation (LIIRLR) on concentrationof diclofenac sodium in the experiment on rats by the method of high-performance liquid chromatography. For study conduct, a total of 15 male rats with body weight of 250–300 g were used. Experimental animals were subdivided into 3 groups. Animals of group 1 received diclofenac sodium per os at the dose of ED50 (8 mg/kg of animal body weight). Animals of group 2 received diclofenac sodium per os (8 mg/kg) and in 15 min were exposed to LIIRLR. Animals of group 3 were exposed to LIIRLR and in 15 min received diclofenac sodium per os at the dose of 8 mg/kg. Animals were sacrificed in 60 min after drug administration. For extraction of diclofenac sodium from rat plasma samples, we used a method of solid-phase extraction, which had been modified due to microoncentrationsof the active substance. In the result of the studies conducted, it has been determined that therapy regimen with the following sequence is the most efficient in the animals studied: exposure of LIIRLR and administration per os of diclofenac sodium in15 min. The results obtained indicate to the fact that concomitant use of LIIRLR potentiates diclofenac sodium. Itwill allow to decrease the dose, influence on its entry and duration of its action in the organism, as well as to decreasethe frequency of drug administration.

scholarly journals The Effect of Laser Irradiation on Reparative Osteogenesis

2018 ◽  
Vol 1 (2) ◽  
pp. 10-19
Author(s):  
Yu. М. Iryanov ◽  
N. A. Kiryanov
Keyword(s):  
Laser Radiation ◽  
Radiation Exposure ◽  
Bone Regeneration ◽  
Laser Irradiation ◽  
Light And Electron Microscopy ◽  
Infrared Laser ◽  
Control Group ◽  
X Ray ◽  
Low Intensity ◽  
The Impact

Introduction: The use of non-medicinal facilities for correcting processes in various pathological conditions is one of the most urgent problems of modern medicine. Purpose of the Work: To study the effect of low-intensity infrared laser radiation on reparative bone formation and angiogenesis in bone regeneration which is formed in treatment of fractures under conditions of transosseous osteosynthesis. Material and Methods: A tibia fracture was modeled experimentally in rats in the control and experimental groups. Reposition and fixation of fragments were performed. The fracture zone in the experimental group animals was exposed to the impact of pulsed infrared laser irradiation of low intensity. Animals from the control group underwent the impact simulation. The operated bones were investigated using the methods of X-ray, light and electron microscopy, X-ray electron probe microanalysis. Results: It was established that laser radiation exposure sessions activated fibrillogenesis and angiogenesis, accelerated compacting of newly formed bone tissue and increased its maturity while primary fracture healing occurred. Prolonged capillary dilatation and endothelium-dependent vasodilation, intensive capillarogenesis were noted after sessions of laser therapy in bone regeneration. Endothelial outgrowth was formed in the lumen of the vessels forming capillary buds that propagate along the “mother” vessels (endovascular capillarogenesis). Conclusion: The data obtained revealed a possible mechanism of laser radiation exposure at the level of a whole organism and proved the effectiveness of its application in clinical practice at the early stages of patient rehabilitation under conditions of transosseous osteosynthesis.

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