Heavy metal nucleotide interactions. 12. Competitive reactions in systems of four nucleotides with cis- or trans-diammineplatinum(II). Raman difference spectrophotometry of the relative nucleophilicity of guanosine, cytidine, adenosine, and uridine monophosphates and analogous DNA bases

1978 ◽  
Vol 100 (2) ◽  
pp. 607-616 ◽  
Author(s):  
Samir Mansy ◽  
Grace Y. H. Chu ◽  
Robert E. Duncan ◽  
R. Stuart Tobias
Keyword(s):  
Heavy Metal ◽  
Dna Bases ◽  
Competitive Reactions ◽  
Nucleotide Interactions ◽  
Relative Nucleophilicity

scholarly journals Synthesis and biological activity of novel heavy metal complexes of 5-amino-1, 10-phenanthroline and 1,10-phenanthroline

2012 ◽  
Vol 10 (4) ◽  
pp. 1034-1041
Author(s):  
Nikolay Kaloyanov ◽  
Mihail Neykov ◽  
Diana Wesselinova ◽  
Georgi Dimitrov
Keyword(s):  
Heavy Metal ◽  
Metal Complexes ◽  
Self Assembly ◽  
Tumour Cells ◽  
Human Tumour ◽  
Competitive Reactions ◽  
Fab Mass Spectrometry ◽  
Spectrum Activity ◽  
High Concentrations ◽  
Ht 29

AbstractNovel heavy metal complexes: Sr(5-NH2-phen)4(NO3)(OH)(H2O)2 (1) (synthesized via a static self-assembly process) and Sn(phen)(NO3)(OH)(H2O) (2), Sn(5-NH2-phen)(OH)(Cl)(H2O) (3), Pb(5-NH2-phen)(NO3)2(H2O) (4) (obtained via metal competitive reactions under mild conditions) were reported. The coordination compounds were characterized by elemental analysis, FTIR-spectroscopy and FAB-mass spectrometry. Their cytotoxicity was measured by MTS-test towards human tumour (MDA-MB-231, HT-29, HeLa, HepG2) and non-tumour diploid (Lep-3) cell lines. The most pronounced cytotoxic effect on all cancer lines showed 1 and 4 at their high concentrations as well as 1 at its lower ones (≤ 4×10−2 mg). Therefore, strontium complex of 5-amino-o-phenanthroline (1) exhibited the widest antitumour spectrum activity, having no toxicity to non-tumour cells at quantities ≤ 4×10−2 mg. The computed EC50 values of 1–4 against MDA-MB-231, HT-29, HeLa, HepG2 varied from 1.40×10−3 to 6.31×10−6 M. Towards Lep-3 substances 2–4 showed IC50 7.52×10−4 − 0.44 M. Substance 1 possess EC50=1.26×10−7 M to the non-tumour cells.

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