Stereochemical, Structural, and Thermodynamic Origins of Stability Differences between Stereoisomeric Benzo[a]pyrene Diol Epoxide Deoxyadenosine Adducts in a DNA Mutational Hot Spot Sequence

2001 ◽  
Vol 123 (29) ◽  
pp. 7054-7066 ◽  
Author(s):  
Shixiang Yan ◽  
Robert Shapiro ◽  
Nicholas E. Geacintov ◽  
Suse Broyde
Keyword(s):  
Hot Spot ◽  
Diol Epoxide ◽  
Deoxyadenosine Adducts

Sequence Context Effects on Mutational Properties of cis-Opened Benzo[c]phenanthrene Diol Epoxide−Deoxyadenosine Adducts in Site-Specific Mutation Studies†

Biochemistry ◽  
1999 ◽  
Vol 38 (3) ◽  
pp. 1144-1152 ◽  
Author(s):  
Ingrid Pontén ◽  
Jane M. Sayer ◽  
Anthony S. Pilcher ◽  
Haruhiko Yagi ◽  
Subodh Kumar ◽  
...  
Keyword(s):  
Context Effects ◽  
Sequence Context ◽  
Site Specific ◽  
Specific Mutation ◽  
Diol Epoxide ◽  
Deoxyadenosine Adducts

Factors Determining Mutagenic Potential for Individual Cis and Trans Opened Benzo[c]phenanthrene Diol Epoxide-Deoxyadenosine Adducts†

Biochemistry ◽  
2000 ◽  
Vol 39 (14) ◽  
pp. 4136-4144 ◽  
Author(s):  
Ingrid Pontén ◽  
Jane M. Sayer ◽  
Anthony S. Pilcher ◽  
Haruhiko Yagi ◽  
Subodh Kumar ◽  
...  
Keyword(s):  
Mutagenic Potential ◽  
Diol Epoxide ◽  
Cis And Trans ◽  
Deoxyadenosine Adducts

ChemInform Abstract: Synthesis of Deoxyadenosine Adducts from the Highly Carcinogenic Fjord Region Diol Epoxide of Benzo(c)phenanthrene.

ChemInform ◽  
2010 ◽  
Vol 24 (15) ◽  
pp. no-no
Author(s):  
M. K. LAKSHMAN ◽  
H. J. C. YEH ◽  
H. YAGI ◽  
D. M. JERINA
Keyword(s):  
Diol Epoxide ◽  
Deoxyadenosine Adducts

Synthesis of deoxyadenosine adducts from the highly carcinogenic fjord region diol epoxide of benzo[c]phenanthrene

1992 ◽  
Vol 33 (47) ◽  
pp. 7121-7124 ◽  
Author(s):  
Mahesh K. Lakshman ◽  
Herman J.C. Yeh ◽  
Haruhiko Yagi ◽  
Donald M. Jerina
Keyword(s):  
Diol Epoxide ◽  
Deoxyadenosine Adducts

Mutation Spectrum in Patients with Wiskott-Aldrich Syndrome and X-linked Thrombocytopenia: Identification of Twelve Different Mutations in the WASP Gene

1996 ◽  
Vol 75 (04) ◽  
pp. 546-550 ◽  
Author(s):  
Marianne Schwartz ◽  
Albert Békássy ◽  
Mikael Donnér ◽  
Thomas Hertel ◽  
Stefan Hreidarson ◽  
...  
Keyword(s):  
Base Pair ◽  
Hot Spot ◽  
Missense Mutations ◽  
Nucleotide Substitutions ◽  
Exon 2 ◽  
Wiskott Aldrich Syndrome ◽  
Base Pair Deletion ◽  
Reliable Diagnosis ◽  
Wasp Gene ◽  
Detection Of Mutations

SummaryTwelve different mutations in the WASP gene were found in twelve unrelated families with Wiskott-Aldrich syndrome (WAS) or X-linked thrombocytopenia (XLT). Four frameshift, one splice, one nonsense mutation, and one 18-base-pair deletion were detected in seven patients with WAS. Only missense mutations were found in five patients diagnosed as having XLT. One of the nucleotide substitutions in exon 2 (codon 86) results in an Arg to Cys replacement. Two other nucleotide substitutions in this codon, R86L and R86H, have been reported previously, both giving rise to typical WAS symptoms, indicating a mutational hot spot in this codon. The finding of mutations in the WASP gene in both WAS and XLT gives further evidence of these syndromes being allelic. The relatively small size of the WASP gene facilitates the detection of mutations and a reliable diagnosis of both carriers and affected fetuses in families with WAS or XLT.

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